Abstract: The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.

Abstract: A method and a circuit for determining the momentary frequency of an analog signal s(t) which is variable over time within a given frequency bandwidth .DELTA.f, as an N-bit number in an N-bit coding range. The circuit includes N detector cells which operate in parallel according to the interferometer principle directly in the original frequency range, to produce respective bit values of the momentary frequency according to a digital code, the bit positions of the code having either odd or even bit functions with respect to the middle of the coding range, depending on the code. Each cell receives from a signal/phase distributor different phases of the signal and with the use of delay elements, comparators and EX-OR and/or EX-NOR gates, depending on whether the cell corresponds to a bit position having an even or an odd bit function, produces an output according to a corresponding equation. For an i-th cell corresponding to the i-th ordered bit position of N, having an odd bit function, the output squ.sub.