Abstract: Methods for screening for agonists and antagonists of GPI-anchored independent intracellular signaling resulting in [Ca2+]i elevation, ERK1, ERK2 and CREB phosphorylation, and Src family kinase activation are described, as well as methods for treatment involving administration of agonists/antagonists of such signaling.
Type:
Grant
Filed:
October 1, 1999
Date of Patent:
June 14, 2005
Assignee:
Licestia Ltd.
Inventors:
Alexey Vladimirovich Titievsky, Dmitri Poteriaev, Urmas Arumäe, Mart Saarma