Abstract: A power injector (10) with help functionality is disclosed. What may be characterized as a ‘help output’ may be displayed on a graphical user interface (11) in response to a request for help. This help output may be based upon a current state of the power injector (10), may be accompanied by a cross-reference to an operator's manual for the power injector (10), may be expanded to provide additional detail, or any combination thereof. At least one system screen that relates to the help output may be displayed (e.g., simultaneously, sequentially). The help functionality may be in the form of having the power injector (10) incorporate help mode logic (256) that is configured to allow a user to view and obtain information on the various system screens that would be presented when using the power injector (10) to deliver a fluid, but without actually operating the power injector (10) to deliver fluid.

Abstract: The present disclosure relates generally to a process for the synthesis of 1,4,7,10 -tetraazacyclododecane ligands, chelates, and derivatives thereof. In particular, the present disclosure is directed to a process for the synthesis of 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane (DOTA) ligands, corresponding DOTA-metal chelates, and various derivatives thereof.

Abstract: Various structures are used in a front-loading injector, for mounting the syringe to the injector and/or preventing leakage of spilled fluid from an external surface of a syringe into the vicinity of the drive ram. A conically-shaped structure on the rearward end of the syringe is specifically disclosed.

Abstract: A dual one-way check valve arrangement (300) that may be used for assessing an operating condition of at least one of first and second check valves (304, 308) situated in series along/within a section of a patient-specific section of tubing (244). A pressure sensor (332) may be associated with at least part of the flow path between the first and second check valves (304, 308) and may be operable to provide an indication of a failed condition of at least one of the first and second check valves (304, 308). In one embodiment, the pressure sensor (332) may change from a first state to a second state upon fluid pressure within the flow path between the first and second check valves (304, 308) falling below a predetermined level. For instance, the predetermined level may be a cracking pressure of at least one of the first and second check valves (304, 308). The change in state may be visually discernible on an exterior of the pressure sensor (332).

Abstract: In certain embodiments, a syringe mount of the invention may include a plate, an actuator, and one or more movable members located between the plate and the actuator. Each of the plate and the actuator may have an orifice defined therein, and an imaginary reference axis of the syringe mount may extend through one or both of these orifices. The actuator may be movable relative to the plate in a direction substantially perpendicular to the reference axis. Further, the moveable member(s) may be designed to move (e.g., pivot) toward the reference axis due to movement of the actuator from a first position to a second position and to move (e.g., pivot) away from the reference axis due to movement of the actuator from the second position to the first position.

Abstract: The present invention is directed to control of medical fluid injection systems. For instance, in some embodiments, an injection protocol may be initiated, and an actual flow rate of the medical fluid utilized in the injection protocol may be adjusted based, at least in part, on an inherent system elasticity of the injection system.

Abstract: Disclosed are systems and methods for power injectors incorporating a keep vein open functionality that is operable when an injection protocol (112) is suspended. The injector includes control logic (110) configured to include the injection protocol (112), and a separate drip mode injection protocol (114) executable only during a suspension of the injection protocol (112). In one embodiment, the drip mode injection protocol (114) is automatically or manually initiated immediately after and in response to the suspension of the injection protocol (112). In another embodiment, the drip mode injection protocol (114) is automatically initiated after a predetermined delay from start of the suspension of the injection protocol (112). The configuration parameters for the drip mode injection protocol (114) may be programmable prior to the initiation of an injection procedure, immediately prior to the execution of the drip mode injection protocol (114), or hard-coded into the injector.

Abstract: A foot-activated controller that communicates with at least one medical device is disclosed. This controller may incorporate a number of features. Multiple displays may be positioned on the controller for depicting the functionality of its various actuators. “Tapping” or partially depressing an actuator may cause an output that is representative of its functionality to be generated on its corresponding controller display, while fully depressing an actuator may initiate execution of its assigned function. The function assigned to each of the various actuators may be programmed by an external computer that may communicate with the controller over an appropriate communication link and via a communication port on the controller. Different audible feedbacks may be assigned to the various actuators, for instance to provide an audible indication of the function being executed.

Abstract: A dual head contrast media injection system performs a patency check or test injection, determining flow rate and/or flow volume from the programmed protocol. The tubing that connects syringes to a patient shares only a short common section near to the patient. Appropriate injection steps are taken to compensate for tubing elasticity. A wireless remote control and a touch screen control are provided, improving functionality and information delivery. The display brightness is controlled based on the ambient light, and the display panel includes a double swivel permitting re-orientation. The orientation of the display may also be controlled based on, e.g., the current step, the tilt angle of the powerhead, or a manual control. Furthermore, the display is customizable to identify the type of fluid (contrast, saline, etc.) on either side of the injector, to provide matched color coding, and to provide a folder/tab analogy for retrieving injection protocol parameters.

Abstract: The present invention relates to management of information relating to medical fluids, containers therefor, and medical fluid administration devices for administering such medical fluids to patients. Data tags (e.g., RFID tags) are generally associated with containers of the invention and may be electromagnetically read from and/or written to using an electromagnetic device, for example, that may be associated with a medical fluid administration device of the invention.

Abstract: Disclosed embodiments provide for a syringe mount of a power injector. The syringe mount may include a plurality of syringe retainer components that translate (e.g., move linearly without rotation) toward and away from a longitudinal axis of the injector drive ram. These retainer components may be biased (e.g., via a spring) toward one another and/or the longitudinal axis of the injector drive ram.

Abstract: Various embodiments of syringe plunger driver or ram retraction protocols for a power injector are disclosed. In a first ram retraction protocol (184a), a first ram may be partially retracted (232), followed by a full retraction of a second ram (234), followed by a completion of the retraction of the first ram (238). In a second ram retraction protocol (184b), a first ram may be partially retracted (252), followed by a partial retraction of a second ram (254), and sometime thereafter each of the first and second rams may be completely retracted (260, 262). In a third ram retraction protocol (184c), the first and second rams are simultaneously and partially retracted (272), and sometime thereafter each of the first and second rams are completely retracted (276). In a fourth ram retraction protocol (184d), the first and second rams are simultaneously and fully retracted (292) based upon a programmed input or the like.

Abstract: A power injector (40) includes a movable ram (74) operable to interface with and move a plunger (90a/b) of a syringe (86a/b). The power injector (40) may be operable to automatically determine a proper home position for a particular type of the syringe (86a/b) to be used in a fluid injection sequence. The power injector (40) may also include a ram homing logic (182) operable to automatically move the ram (74) to the home position after the injection sequence. Such automatic homing of the ram (74) may, for example, be initiated by an end of the injection sequence in preparation for another injection sequence, by opening of a faceplate (102a/b), by a user input, or by any combination thereof.

Abstract: The present disclosure generally relates to a new process for the preparation of high purity 5-nitro-isophthalamide compounds, which are useful as intermediates for the preparation of imaging agents, such as iodinated x-ray contrast imaging agents like ioversol, iohexyl and iopamidol.

Abstract: A medical fluid injector, replaceable syringe, and coupling mechanism to engage the syringe plunger to the plunger drive ram of the injector are provided wherein coupling involves a cam cleat-like mechanism, thereby allowing for cooperative movement between the plunger drive ram and syringe plunger. The coupling mechanism of the plunger drive ram is provided with first and second movable members, each having toothed, arcuate surfaces, while the coupling mechanism of the syringe plunger is provided with a knurled cavity. Disengagement of the coupling mechanism is facilitated by translational movement of a face plate located on the forward end of the injector housing.

Abstract: A hand-held remote for a medical fluid injector includes a syringe and a conduit which may be coupled to a pressure transducer on a control circuit of the injector. Movement of a plunger within a syringe body on the syringe creates a pressure which is sensed by the pressure transducer and the control circuit responds to the sensed pressure by causing fluid to be ejected from, or drawn into, a syringe mounted to the injector. The pressure developed by the remote provides tactile feedback to an operator for improved control over injections.

Abstract: A method of operation for a magnetic resonance imaging suite. A power supply of magnetic resonance injector system receives electrical power from an AC power outlet, both of which are located outside of a shielded room of the magnetic resonance imaging suite. Electrical power from the power supply of the magnetic resonance injector system is conveyed (via an appropriate power connection) into the shielded room of the magnetic resonance imaging suite and to a component (e.g., a power head) of the magnetic resonance injector system located inside the shielded room. While this electrical power is being conveyed, radio frequency energy emitted from the power connection is being filtered.

Abstract: Various sealing structures are used in a front-loading injector, for preventing leakage of spilled fluid from an external surface of a syringe into the vicinity of the drive ram. For example, a sealing gasket may be incorporated into the front face of the injector housing, for mating to the rearward circular edge of the cylindrical body of a syringe. Alternatively, sealing and locking functions may be performed by a single structure on the rearward end of the syringe. Further, leakage may be prevented by including a non-planar sealing flange on the syringe, positioned on the syringe forward of the locking structure, or by a two-piece structure, including a syringe and a separate leakage stopping washer for surrounding the syringe to halt the flow of fluid along the exterior of the syringe. As part of this aspect, or as an independent feature, the syringe may include an annularly discontinuous flange forward of the locking structure, for providing mechanical support for the syringe against the injector.

Abstract: Various sealing structures are used in a front-loading injector, for preventing leakage of spilled fluid from an external surface of a syringe into the vicinity of the drive ram. For example, a sealing gasket may be incorporated into the front face of the injector housing, for mating to the rearward circular edge of the cylindrical body of a syringe. Alternatively, sealing and locking functions may be performed by a single structure on the rearward end of the syringe. Further, leakage may be prevented by including a non-planar sealing flange on the syringe, positioned on the syringe forward of the locking structure, or by a two-piece structure, including a syringe and a separate leakage stopping washer for surrounding the syringe to halt the flow of fluid along the exterior of the syringe. As part of this aspect, or as an independent feature, the syringe may include an annularly discontinuous flange forward of the locking structure, for providing mechanical support for the syringe against the injector.

Abstract: An injector that may be used to deliver radiographic contrast media and/or flushing solution into a patient's vascular system for the purposes such as obtaining enhanced diagnostic x-ray images. The injector includes a drive ram movable along its longitudinal axis, and a control system that controls operation of the injector. The control system has an enabled state that allows an injection procedure to be performed, and a disabled state that does not allow an injection procedure to be performed. The control system transitions from the disabled state to the enabled state in response to movement of the drive ram along its longitudinal axis.