Abstract: Disclosed herein are methods for preventing or treating non-arteritic anterior ischemic optic neuropathy in a subject by administering to the subject a nucleic acid molecule comprising a nucleic acid sequence encoding OCT4, a nucleic acid sequence encoding SOX2, and a nucleic acid sequence encoding KLF4.
Type:
Grant
Filed:
May 4, 2023
Date of Patent:
March 18, 2025
Assignee:
Life Biosciences, Inc.
Inventors:
Michel Wathier, Jennifer Cermak, Joan Mannick
Abstract: The present invention relates to amino acid salts of nicotinic acid and nicotinamide and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+: wherein A, L, M1, M2, R1, R2, and R3 are as described herein.
Type:
Application
Filed:
August 1, 2019
Publication date:
October 7, 2021
Applicants:
Jumpstart Fertility Pty Ltd, Life Biosciences, Inc.
Inventors:
Sebastian Mario MARCUCCIO, Rohan David JOYCE, Michel WATHIER, Roland DOLLE, Simon TUCKER
Abstract: The present invention relates to inorganic salts of nicotinic acid mononucleotides and compositions of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+: wherein A, M1, M2, k, R1, R2, and R3 are as described herein.
Type:
Grant
Filed:
April 3, 2019
Date of Patent:
May 19, 2020
Assignees:
Jumpstart Fertility Pty Ltd, Life Biosciences, Inc.
Inventors:
Michel Wathier, Roland Dolle, Sebastian Mario Marcuccio, Rohan David Joyce, Simon Tucker
Abstract: The present invention provides a method of forming one or more biological-binding areas on a substrate for biological-testing. The method includes activating at least a portion of a glass-ceramic substrate comprising glass and one or more metal containing compounds. The one or more metal containing compounds have a range of diameters that are less than about 300 nanometers in diameter and are spaced an average distance of at least one-half the midpoint of the diameter range apart. The one or more metals include compounds selected from metal oxides, metal nanoparticles, metal alloys, and atomic metals. The glass-ceramic substrate is heated to a temperature near the glass transformation temperature to form one or more metal nanoparticles in one or more ceramic biological-binding areas. The glass-ceramic substrate is etched to expose one or more metal.
Type:
Grant
Filed:
August 28, 2008
Date of Patent:
July 23, 2013
Assignee:
Life Bioscience, Inc.
Inventors:
Jeb H. Flemming, Colin T. Buckley, Carrie Schmidt
Abstract: This invention provides an inexpensive and rapid method for fabricating a high-anisotropic-etch ratio, shaped glass structures using a novel photosensitive glass composition. Structures of the photosensitive glass may include micro-channels, micro-optics, microposts, or arrays of hollow micro-needles. Furthermore, such shaped glass structures can be used to form a negative mold for casting the shape in other materials.
Type:
Grant
Filed:
March 28, 2008
Date of Patent:
January 29, 2013
Assignee:
Life Bioscience, Inc.
Inventors:
Jeb H. Flemming, Colin T. Buckley, Carrie Schmidt
Abstract: This invention provides an inexpensive and rapid method for fabricating a high-anisotropic-etch ratio, shaped glass structures using a novel photosensitive glass composition. Structures of the photosensitive glass may include micro-channels, micro-optics, microposts, or arrays of hollow micro-needles. Furthermore, such shaped glass structures can be used to form a negative mold for casting the shape in other materials.
Type:
Grant
Filed:
March 28, 2008
Date of Patent:
January 17, 2012
Assignee:
Life Bioscience, Inc.
Inventors:
Jeb H. Flemming, Colin T. Buckley, Carrie Schmidt
Abstract: The present invention includes micro-sphere composition, methods of making binding assays. The present invention also includes a micro-sphere for binding biological molecules without pretreatment. The micro-sphere includes a spherical glass substrate having one or more metal nanoparticle regions that are exposed from within the glass, wherein the micro-sphere is capable of binding biological molecules without pretreatment.
Type:
Grant
Filed:
April 7, 2009
Date of Patent:
December 13, 2011
Assignee:
Life Bioscience, Inc.
Inventors:
Jeb H. Flemming, Colin T. Buckley, Carrie Schmidt
Abstract: The present invention includes composition, methods of making and methods of using a multi-nano-well plate having a first layer at least partially disposed on the substrate and one or more nano-wells that extends through the first layer that extends toward the substrate, wherein the one or more nano-wells having an opening in the first layer connected to bottom layer by one or more walls.
Type:
Application
Filed:
July 24, 2009
Publication date:
January 28, 2010
Applicant:
Life BioScience, Inc.
Inventors:
Jeb H. Flemming, Colin T. Buckley, Blake Ridgeway
Abstract: The present invention includes micro-sphere composition, methods of making binding assays. The present invention also includes a micro-sphere for binding biological molecules without pretreatment. The micro-sphere includes a spherical glass substrate having one or more metal nanoparticle regions that are exposed from within the glass, wherein the micro-sphere is capable of binding biological molecules without pretreatment.
Type:
Application
Filed:
April 7, 2009
Publication date:
October 15, 2009
Applicant:
Life BioScience, Inc.
Inventors:
Jeb H. Flemming, Colin T. Buckley, Carrie Schmidt