Patents Assigned to LIFE & BRAIN GMBH
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Patent number: 9844572Abstract: The invention relates to the treatment of diseases or disorders of the nervous system. In particular, the invention relates to the treatment of diseases or disorders of the nervous system by stem cell therapy, in particular therapy with neural precursor cells. In preferred aspects of the invention, inhibitors of chemoattraction are administered prior to, concomitantly with, or subsequently to the administration of neural precursor cells.Type: GrantFiled: March 24, 2010Date of Patent: December 19, 2017Assignee: Life & Brain GmbHInventors: Oliver Brüstle, Philipp Koch, Julia Ladewig
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Patent number: 9844522Abstract: The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient.Type: GrantFiled: August 6, 2013Date of Patent: December 19, 2017Assignees: LIFE & BRAIN GMBH, RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT BONNInventors: Björn Scheffler, Martin Glas, Anja Wieland
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Patent number: 9573960Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.Type: GrantFiled: June 15, 2012Date of Patent: February 21, 2017Assignees: Life & Brain GmbH, Rheinische Friedrich-Wilhelms UniversitatInventors: Björn Scheffler, Martin Glas, Matthias Simon, Sabine Gogolok, Daniel Trageser, Roman Reinartz, Anja Wieland
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Patent number: 9192631Abstract: A method for obtaining human microglial precursor cells, comprising: (a) providing a cell population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating the cell population comprising neural precursor cells into microglial precursor cells by culturing in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors; (c) expanding and enriching microglial precursor cells in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors and 10 to 150 ng/ml GM-CSF; and (d) isolating microglial precursor cells comprising CD45-positive cells.Type: GrantFiled: April 28, 2010Date of Patent: November 24, 2015Assignee: Life & Brain GMBHInventors: Harald Neumann, Kristin Roy, Oliver Brüstle, Michael Peitz
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Publication number: 20150148390Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.Type: ApplicationFiled: June 15, 2012Publication date: May 28, 2015Applicant: Life & Brain GmbHInventors: Björn Scheffler, Martin Glas, Matthias Simon, Sabine Gogolok, Daniel Trageser, Roman Reinartz, Anja Wieland
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Patent number: 8481492Abstract: The invention relates to a fusion protein and a method for the generation of the fusion protein of the invention. Further, the invention relates to the use of the fusion protein of the invention for the generation of induced pluripotent cells. Moreover, the invention relates to a composition comprising at least one fusion protein of the invention.Type: GrantFiled: June 15, 2009Date of Patent: July 9, 2013Assignee: Life & Brain GmbHInventors: Frank Edenhofer, Manal Hadenfeld, Michael Peitz, Marc-Christian Thier
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Publication number: 20120093832Abstract: The invention relates to the treatment of diseases or disorders of the nervous system. In particular, the invention relates to the treatment of diseases or disorders of the nervous system by stem cell therapy, in particular therapy with neural precursor cells. In preferred aspects of the invention, inhibitors of chemoattraction are administered prior to, concomitantly with, or subsequently to the administration of neural precursor cells.Type: ApplicationFiled: March 24, 2010Publication date: April 19, 2012Applicant: Life & Brain GmbHInventors: Oliver Brüstle, Philipp Koch, Julia Ladewig
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Publication number: 20110177557Abstract: The invention relates to a fusion protein and a method for the generation of the fusion protein of the invention. Further, the invention relates to the use of the fusion protein of the invention for the generation of induced pluripotent cells. Moreover, the invention relates to a composition comprising at least one fusion protein of the invention.Type: ApplicationFiled: June 15, 2009Publication date: July 21, 2011Applicant: Life & Brain GmbHInventors: Frank Edenhofer, Manal Bosnali, Michael Peitz, Marc-Christian Thier
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Publication number: 20110104691Abstract: The present invention relates to methods for testing for a predisposition or presence of androgenetic alopecia comprising testing a sample obtained from a prospective patient or from a person suspected of carrying a predisposition for androgenetic alopecia. The invention also relates to a genetic marker for androgenetic alopecia characterised in that the genetic marker is located in a chromosomal region of human chromosome 20p11 and wherein the genetic marker is selected from the group consisting of a single nucleotide polymorphism (SNP), variable number of tandem repeat (VNTR), microsatellites or short tandem repeats (STR). Further, the invention relates to a diagnostic composition for the detection of androgenetic alopecia or a predisposition therefore as well as to a kit.Type: ApplicationFiled: April 7, 2009Publication date: May 5, 2011Applicants: LIFE & BRAIN GMBH, HEINRICH-HEIN-UNIVERSITAT DUSSELDORF, RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITATInventors: Markus M. Nöthen, Felix F. Brockschmidt, Axel Hillmer, Roland Kruse
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Publication number: 20110052642Abstract: The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.Type: ApplicationFiled: September 9, 2009Publication date: March 3, 2011Applicant: Life &Brain GmbHInventors: Björn Scheffler, Matthias Simon, Oliver Brüstle, Ulrich Johannes Herrlinger, Martin Glas
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Publication number: 20100254946Abstract: The present invention relates to a nucleic acid molecule, encoding a polypeptide having P2Y5 receptor function wherein said nucleic acid molecule comprises: (a) a nucleic acid molecule encoding a polypeptide having the amino acid sequence of SEQ ID NO:2; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO:1; (c) a nucleic acid molecule having the sequence of SEQ ID NO:1, wherein each thymidine is replaced by uridine; (d) a nucleic acid molecule that hybridizes under stringent conditions to the complementary strand of a nucleic acid molecule of (a), (b) or (c); (e) a nucleic acid molecule encoding a polypeptide having at least 80% sequence identity to the polypeptide of (a); or (f) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b), (c) or (d); for the diagnosis, treatment and/or prevention of hair-loss and the diagnosis of a predisposition for hair-loss.Type: ApplicationFiled: September 25, 2008Publication date: October 7, 2010Applicant: LIFE & BRAIN GMBHInventors: Regina Betz, Markus Nothen, Sandra Pasternack, Khalid Al Aboud