Patents Assigned to Life Medical Science, Inc.
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Patent number: 6943211Abstract: Provided is a composition comprising a pre-formed, hydrolytically susceptible non-addition polyanionic polymer comprising polymer strands formed from at least one ethylenically unsaturated monomer and linking the polymer strands by at least one linking moiety comprising a hydrolytically susceptible bond, wherein at least one of which monomers has: i) one or more functional groups that can be titrated with base to form negatively charged functional groups; or ii) one or more precursor groups that are precursors of the functional groups that can be titrated with base; which precursor groups are converted to the functional groups.Type: GrantFiled: August 23, 2000Date of Patent: September 13, 2005Assignee: Life Medical Sciences, Inc.Inventors: Jeffrey A. Hubbell, Petra van de Wetering, Didier Cowling
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Patent number: 6872384Abstract: Provided is a method of treating an area affected by a trauma, such as a corneal wound or internal trauma, comprising administering to the affected area a trauma treating effective amount of a composition comprising a polyanionic polymer.Type: GrantFiled: August 23, 2000Date of Patent: March 29, 2005Assignee: Life Medical Sciences, Inc.Inventors: Richard Franklin, Didier S P Cowling, Jeffrey A. Hubbell, Petra van de Wetering
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Patent number: 6870012Abstract: A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene oxide) unit, E is a chain extender unit, n=0-20, and m is greater than 2. The ethylene oxide:propylene oxide ratio ranges from about 0.2:1 to about 40:1. The composition has a final viscosity at a final temperature of more than twice the initial viscosity at an initial temperature wherein the final temperature is at least 10° C. higher than the initial temperature. The composition is combined with either a cellular material for tissue engineering, a cellular material for effecting repair or healing in a patient, or a bioactive agent.Type: GrantFiled: April 24, 2003Date of Patent: March 22, 2005Assignee: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Avraham Levi
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Publication number: 20040156819Abstract: The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.Type: ApplicationFiled: December 31, 2003Publication date: August 12, 2004Applicant: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Eli Pines, Anna Hotovely
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Patent number: 6696499Abstract: The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.Type: GrantFiled: October 16, 2000Date of Patent: February 24, 2004Assignee: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Eli Pines, Anna Hotovely
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Patent number: 6579951Abstract: A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene oxide unit, E is a chain extender or crosslinking agent unit, n ranges from 0 to 20, and m is greater than 2, said block polymer possessing an EO (ethylene xide):PO (propylene oxide) ratio ranging from about 0.2:1 to about 40:1, said composition having a final viscosity at a final temperature of more than twice the initial viscosity at an initial temperature, said final temperature being at least 10° C. higher than said initial temperature.Type: GrantFiled: June 6, 2000Date of Patent: June 17, 2003Assignee: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Avraham Levi
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Publication number: 20010009662Abstract: The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and bum dressings and producing biodegradable articles, among numerous others.Type: ApplicationFiled: March 13, 2001Publication date: July 26, 2001Applicant: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Theodor Stern, Avraham Levi
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Patent number: 6211249Abstract: The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and bum dressings and producing biodegradable articles, among numerous others.Type: GrantFiled: January 13, 1998Date of Patent: April 3, 2001Assignee: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Theodor Stern, Avraham Levi
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Patent number: 6136333Abstract: The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.Type: GrantFiled: July 11, 1997Date of Patent: October 24, 2000Assignee: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Eli Pines, Anna Hotovely
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Patent number: 5895656Abstract: The present invention relates to the treatment of keloid and hypertrophic scars by covering the scar with a gas-or gel-filled cushion made of smooth or textured silicone sheeting. It relates particularly to a cushion in the form of a hollow bag filled with completely dry air, inert gel or an inert gas. The invention also relates to a silicone sheeting cushion enclosing silicone beads, polymeric pieces or bodies made of polyfluoroethylene sheeting or a related polymer which produces a negative static charge or, preferably, a silicone sponge or hydrophobic gel, most preferably silicone gel.Type: GrantFiled: October 18, 1996Date of Patent: April 20, 1999Assignee: Life Medical Sciences, Inc.Inventors: Bernard Hirshowitz, Ella Lindenbaum, Yaron Har-Shai
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Patent number: 5711958Abstract: The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition comprising chain-extended poly(hydroxy-carboxylic acid)/poly(oxyalkylene) ABA triblocks to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.Type: GrantFiled: July 11, 1996Date of Patent: January 27, 1998Assignee: Life Medical Sciences, Inc.Inventors: Daniel Cohn, Eli Pines
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Patent number: 5681561Abstract: The present invention relates to compositions and methods for enhancing the success of autologous fat grafting in a patient. The compositions according to the present invention are useful for enhancing autologous fat grafting by improving the survival rate of lipocytes which are injected into a patient as part of a fat grafting procedure. These compositions comprise a fat grafting effective amount of autologous lipocytes in combination with a lipocyte growth effective amount of a non-steroidal anabolic hormone selected from insulin, triiodothyronine/thyroxine (T.sub.3 or T.sub.4), mixtures thereof, and optionally, growth hormone, most preferably a mixture of all three hormones because of the favorable effect these three hormones exhibit in combination to promote autologous fat grafting, the hormones being further combined with a lipocyte growth effective amount of a nutrient medium, preferably a serum free nutrient medium as at least a minimum essential medium.Type: GrantFiled: June 7, 1995Date of Patent: October 28, 1997Assignee: Life Medical Sciences, Inc.Inventors: Bernard Hirshowitz, Ella Lindenbaum, Yaron Har-Shai
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Patent number: 5591709Abstract: The present invention relates to wound treatment formulations and methods for treating wounds utilizing these formulations. The formulations according to the present invention are useful for treating wounds by accelerating wound healing. These formulations generally comprise an effective amount of a non-steroidal anabolic hormone such as insulin, growth hormone, triiodothyronine, thyroxine or mixtures thereof, in combination with a cellular nutrient medium, preferably MCDB 153.Type: GrantFiled: January 18, 1995Date of Patent: January 7, 1997Assignee: Life Medical Sciences, Inc.Inventor: Ella Lindenbaum
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Patent number: 5461030Abstract: The present invention relates to formulations and methods for treating wounds utilizing these formulations. The formulations according to the present invention are useful for treating wounds by accelerating wound healing. These formulations comprise an effective amount of a serum free cellular nutrient medium in combination with an effective amount of at least one cellular growth stimulating compound, e.g. a natural anabolic hormone or transforming growth factor.Type: GrantFiled: November 29, 1993Date of Patent: October 24, 1995Assignee: Life Medical Science, Inc.Inventor: Ella Lindenbaum
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Patent number: 5263971Abstract: An apparatus for closing wide skin defects may include two long pins for insertion underneath the skin close to the margins of the defect. Two U-shaped members may also be provided. Each U-shaped member may include a sharp hook at the end of each leg adapted to pierce the skin and to engage one pin each in two places. A contracting screw may connect the two members and approximate the pins and the skin margins until final closure of the defect. A parallel alignment mechanism may also be provided to maintain the U-shaped members in parallel alignment.Type: GrantFiled: February 13, 1992Date of Patent: November 23, 1993Assignee: Life Medical Sciences, Inc.Inventors: Bernard Hirshowitz, Amnon Levy
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Patent number: D352356Type: GrantFiled: December 3, 1992Date of Patent: November 8, 1994Assignee: Life Medical Sciences, Inc.Inventors: Bernard Hirshowitz, Amnon Levy