Patents Assigned to Life Sciences, Inc.
  • METHOD AND SYSTEM FOR DETERMINING AT LEAST ONE PARAMETER OF INTEREST OF A MATERIAL
    Publication number: 20210063356
    Abstract: A method for determining at least one parameter of interest of a material comprises directing, using a radio frequency (RF) applicator, one or more RF energy pulses into a region of interest, the region of interest comprising a material having a parameter of interest and at least one reference, the material and the reference separated by at least one boundary; detecting, using an acoustic receiver, at least one multi-polar acoustic signal generated in the region of interest in response to the RF energy pulses; processing the at least one multi-polar acoustic signal to determine an electric field strength at the boundary; calculating a voltage standing wave ratio (VSWR) of the one or more RF energy pulses; and determining the at least one parameter of interest of the material based at least on the determined electric field strength and the VSWR.
    Type: Application
    Filed: August 29, 2019
    Publication date: March 4, 2021
    Applicant: ENDRA Life Sciences Inc.
    Inventor: Jang Hwan Cho
  • Compounds and methods for detection of enzymes that remove methyl succinyl groups from epsilon-amino lysine moieties
    Patent number: 10920265
    Abstract: Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ?-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ?-amino of a lysine.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: February 16, 2021
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Konrad T. Howitz, Zhongda Zhang, Anne Kisielewski, Elizabeth Dale, Wayne Forrest Patton
  • METHOD AND SYSTEM FOR IDENTIFYING A MATERIAL OF INTEREST
    Publication number: 20210038190
    Abstract: A method for identifying a material of interest comprises directing, using a radio frequency (RF) applicator, one or more RF energy pulses into a region of interest, the region of interest comprising the material of interest and at least one reference that are separated by at least one boundary; detecting, using an acoustic receiver, at least one multi-polar acoustic signal generated in the region of interest in response to the RF energy pulses; processing the at least one multi-polar acoustic signal to determine an electric field strength at the boundary; and identifying the material of interest based at least on the determined electric field strength.
    Type: Application
    Filed: August 8, 2019
    Publication date: February 11, 2021
    Applicant: ENDRA Life Sciences Inc.
    Inventor: Jang Hwan Cho
  • Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
    Patent number: 10907213
    Abstract: Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: February 2, 2021
    Assignee: MDNA Life Sciences Inc.
    Inventors: Ryan L. Parr, Robert Thayer, Gabriel Dakubo, Jennifer Creed, Kerry Robinson, Andrea Maggrah, Brian Reguly, Andrew Harbottle, Mark Birch-Machin
  • Systems and methods for imaging biological tissue structures
    Patent number: 10898166
    Abstract: Combined transducer arrays for imaging features of tissue include a transducer array configured for transmit-receive ultrasound imaging, and a transducer array configured for receive-only thermoacoustic imaging. The transmit-receive transducer array includes a plurality of transmit-receive array elements, and the receive-only transducer array includes a plurality of receive-only array elements. The receive-only array elements are registered with and surround the transmit-receive array elements. The receive-only transducer array and transmit-receive transducer array may be housed in an ultrasound probe. The combined transducer arrays may be used in composite imaging of tissue, based on the registration of the transmit-receive array elements and the receive-only array elements.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: January 26, 2021
    Assignee: ENDRA Life Sciences Inc.
    Inventors: Michael M. Thornton, Paul A. Picot
  • Method for delivery of biological molecule to nervous tissue
    Patent number: 10898590
    Abstract: A method for delivery of a therapeutic agent to a nervous tissue. In particular, a method of delivering a therapeutic agent to a nervous tissue protected by the brain-blood barrier or meninges is disclosed. The method for delivery allows delivery of a therapeutic agent to a nervous tissue with high efficiency. In addition, the delivery method of a therapeutic agent to a nervous tissue is safe since it has lower side effects such as nervous damage than a method of administering a therapeutic agent directly to a nervous tissue.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: January 26, 2021
    Assignee: KOLON LIFE SCIENCE, INC.
    Inventors: Sujeong Kim, Heonsik Choi, Kyoungbaek Choi, Minjung Kim, Yejin Kwon, Hyeonyoul Lee, Minju Kim, Daewook Kim, Jangjoon Park, Yeomoon Sim
  • DYES FOR ANALYSIS OF PROTEIN AGGREGATION
    Publication number: 20210009809
    Abstract: Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
    Type: Application
    Filed: August 6, 2020
    Publication date: January 14, 2021
    Applicant: Enzo Life Sciences, Inc.
    Inventors: Wayne Forrest Patton, Sergiy M. Yarmoluk, Praveen Pande, Vladyslava Kovalska, Lijun Dai, Kateryna Volkova, Jack Coleman, Mykhaylo Losytskyy, Anthony Ludlam, Anatoliy Balanda, Dee Shen
  • Compositions and methods for detecting cancer cells in a tissue sample
    Patent number: 10890588
    Abstract: This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: January 12, 2021
    Assignee: ISI Life Sciences, Inc.
    Inventors: John Fante, Theodore Hessler, III, Robert M. Moriarty, Richard Pariza, Gerald F. Swiss, David White, Craig Keshishian
  • Shielded ultrasound transducer and imaging system employing the same
    Patent number: 10888898
    Abstract: An ultrasound transducer with at least one piezoelectric element configured to convert received acoustic signals into an electric potential, a shield connectable to ground and overlying the at least one piezoelectric element through which the acoustic signals pass before being received by the at least one piezoelectric element, the shield having acoustic conductivity and electrical attenuation characteristics that enable the acoustic signals to propagate therethrough while reducing a 100 volt per centimeter electric field to below a threshold level so that the piezoelectric element is exposed to a threshold electrical potential at least less than or equal to 10 ?V, and a housing accommodating the at least one piezoelectric element and shield.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: January 12, 2021
    Assignee: ENDRA Life Sciences Inc.
    Inventors: Michael M. Thornton, Stanley Emil Jelic
  • SYSTEMS AND METHODS FOR DRUG DEVELOPMENT
    Publication number: 20200411143
    Abstract: Systems and methods are provided for drug development under a fully transparent development model. The model is configured to provide transparency to the patients, the researchers, clinicians, physicians, and any other registered users of the system who wish to contribute. According to various embodiments, the system and model enable drug development that leverage the combined wisdom and insight of the user population eliminating many of the drawbacks of conventional development approaches. In one embodiment, the system includes drug development engine configured to manage execution of parameters of a clinical trial, including collection of health and treatment information from a patient population. The development engine can publish collected execution data for review and analysis.
    Type: Application
    Filed: September 16, 2020
    Publication date: December 31, 2020
    Applicant: Transparency Life Sciences, Inc.
    Inventor: Tomasz Sablinski
  • Method and system of microfluidic immunoassay using magnetic beads
    Patent number: 10877032
    Abstract: A microfluidic Western blot method and system including a microfluidic western blot method for immunoassay of proteins, the method including introducing a sample including the proteins onto a chip; electrophoretically separating the proteins; binding the separated proteins to beads to form protein-attached beads, the beads being magnetic; flowing the protein-attached beads into a magnetic holding region; applying a magnetic field to the magnetic holding region to fix the protein-attached beads in place within the magnetic holding region; binding primary antibodies to target proteins on the protein-attached beads; binding secondary antibodies to the bound primary antibodies; and detecting the bound secondary antibodies.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: December 29, 2020
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Andrew Barry, Laurel Provencher, Seth Cohen, I-Jane Chen, Jun Yan, Jingjing Wang
  • Fluorescent dyes and methods of use thereof
    Patent number: 10875886
    Abstract: Provided are methods for labeling target molecules, such as nucleic acids, with fluorescent dye compounds having the formula One method embodiment includes contacting reactive group Z of the fluorescent dye compound with the target molecule such that reactive group Z reacts with the target molecule to form a covalent bond between the group and the target molecule. Another method embodiment includes contacting a fluorescent dye compound that further includes a first member of a binding pair, with a target molecule that includes a second member of the binding pair. Also provided are target molecules labeled with the fluorescent dye compounds.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 29, 2020
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Zaiguo Li, Praveen Pande
  • THERMOACOUSTIC IMAGING METHODS AND SYSTEMS UTILIZING PARALLEL PHASED ARRAY TRANSMISSION ELEMENTS
    Publication number: 20200375531
    Abstract: A method for providing an image of a subject by utilizing an array of transmission elements in a thermoacoustic imaging apparatus.
    Type: Application
    Filed: May 28, 2019
    Publication date: December 3, 2020
    Applicant: ENDRA Life Sciences Inc.
    Inventors: Christopher Nelson Davis, Paul A. Picot
  • Method and apparatus for laser ablation under ultrasound guidance
    Patent number: 10835215
    Abstract: A method for minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, comprising: guiding a laser fiber within a patient with a guidance tool; measuring a temperature within the target tissue and the safety zone based on an invasive and a non-invasive thermal sensor; computing a thermal profile in conjunction with a real-time tissue image adapted for guidance of the laser fiber with the guidance tool within the patient; and controlling a laser to deliver energy through the laser fiber, to deliver a minimally therapeutic ablation therapy to the target tissue while ensuring that the safety zone is maintained in a non-ablation condition, based on at least a treatment plan, the measured temperature, and the thermal profile.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: November 17, 2020
    Assignee: CONVERGENT LIFE SCIENCES, INC.
    Inventors: Dinesh Kumar, Amit Vohra, Daniel S. Sperling
  • Use of ribose for treatment of subjects having congestive heart failure
    Patent number: 10821123
    Abstract: A method for treating a human subject having congestive heart failure is disclosed herein. An exemplary method includes orally administering a 10 g to 50 g dose of D-ribose daily to a subject having congestive heart failure, wherein the D-ribose is administered in a single dose after fasting, and the administration of D-ribose is continued over a period of time effective to improve cardiac and/or physical function of the subject.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: November 3, 2020
    Assignee: Bioenergy Life Science, Inc.
    Inventors: Jeffrey A. Thompson, Raj Khankari
  • METHOD FOR MANUFACTURING A RADIO FREQUENCY APPLICATOR
    Publication number: 20200303803
    Abstract: A method for manufacturing a radio frequency (RF) applicator which includes covering a ceramic insert with a coating, wherein the ceramic insert has dimensions that substantially match an internal volume of an open-ended, hollow waveguide, and wherein the ceramic insert has a recess therein configured to accept a radio frequency emitter, heating the waveguide to a temperature that is above a melting point of the coating, placing the coated ceramic insert into the internal volume of the heated waveguide, wherein the internal volume is completely filled except for the recess, and cooling the waveguide, ceramic insert, and coating to a temperature below the melting point of the coating so that the coating solidifies and fills gaps between facing surfaces of the insert and the waveguide.
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Applicant: ENDRA Life Sciences Inc.
    Inventors: Christopher Nelson Davis, Charlton Chen, Michael M. Thornton
  • Systems and methods for drug development
    Patent number: 10783986
    Abstract: Systems and methods are provided for drug development under a fully transparent development model. The model is configured to provide transparency to the patients, the researchers, clinicians, physicians, and any other registered users of the system who wish to contribute. According to various embodiments, the system and model enable drug development that leverage the combined wisdom and insight of the user population eliminating many of the drawbacks of conventional development approaches. In one embodiment, the system includes drug development engine configured to manage execution of parameters of a clinical trial, including collection of health and treatment information from a patient population. The development engine can publish collected execution data for review and analysis.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: September 22, 2020
    Assignee: Transparency Life Sciences, Inc.
    Inventor: Tomasz Sablinski
  • SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION
    Publication number: 20200291448
    Abstract: Provided is a compound having the structure: (SIG)-(SI-MOD)m where SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. When MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided are methods of determining whether a sample, such as a cell, comprises an activator, such as a nitroreducase, using the compound. Further provided are methods of determining whether a mammalian cell is hypoxic using the compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase using the compound where nitroreductase is the activator is also provided.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Applicant: ENZO LIFE SCIENCES, INC.
    Inventors: Irina LEBEDEVA, Wayne Forest PATTON, Maciej SZCZEPANIK, Yuejun XIANG, Praveen PANDE
  • COMPOUNDS AND METHODS FOR DETECTION OF ENZYMES THAT REMOVE METHYL SUCCINYL GROUPS FROM EPSILON-AMINO LYSINE MOIETIES
    Publication number: 20200283821
    Abstract: Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ?-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ?-amino of a lysine.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 10, 2020
    Applicant: Enzo Life Sciences, Inc.
    Inventors: Konrad T. Horwitz, Zhongda Zhang, Anne Kisielewski, Elizabeth Dale, Wayne Forrest Patton
  • MULTISIGNAL REAGENTS FOR LABELING ANALYTES
    Publication number: 20200284786
    Abstract: Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. In this assay, the amount of the signal or the first member of the second binding pair bound to the binding agent is inversely proportional to the analyte in the sample.
    Type: Application
    Filed: March 9, 2020
    Publication date: September 10, 2020
    Applicant: Enzo Life Science, Inc.
    Inventors: Jack Coleman, Maciej Szczepanik, Richard Jin