Patents Assigned to Lifebond Ltd
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Patent number: 10202585Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.Type: GrantFiled: April 25, 2015Date of Patent: February 12, 2019Assignee: LIFEBOND LTDInventors: Guy Tomer, Orahn Preiss-Bloom
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Patent number: 9655988Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.Type: GrantFiled: April 22, 2015Date of Patent: May 23, 2017Assignee: LIFEBOND LTDInventors: Natalie Iram, Orahn Preiss-Bloom, Ishay Attar
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Patent number: 9636433Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.Type: GrantFiled: February 17, 2015Date of Patent: May 2, 2017Assignee: LIFEBOND LTDInventors: Natalie Iram, Orahn Preiss-Bloom, Ishay Attar
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Publication number: 20150291939Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.Type: ApplicationFiled: April 25, 2015Publication date: October 15, 2015Applicant: LIFEBOND LTD.Inventors: Guy TOMER, Orahn PREISS-BLOOM
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Patent number: 9066991Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.Type: GrantFiled: December 22, 2010Date of Patent: June 30, 2015Assignee: LIFEBOND LTD.Inventors: Orahn Preiss-Bloom, Guy Tomer
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Patent number: 9044456Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).Type: GrantFiled: February 25, 2014Date of Patent: June 2, 2015Assignee: LIFEBOND LTD.Inventor: Orahn Preiss-Bloom
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Patent number: 9017664Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.Type: GrantFiled: December 17, 2007Date of Patent: April 28, 2015Assignee: Lifebond Ltd.Inventors: Orahn Preiss-Bloom, Ishay Attar, Natalie Iram
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Patent number: 8961544Abstract: Patches comprising dry gelatin compositions.Type: GrantFiled: August 5, 2011Date of Patent: February 24, 2015Assignee: Lifebond Ltd.Inventors: Chagai Komlos, Guy Tomer, Maria Ziv, Orahn Preiss-Bloom, Thomas Bayer
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Publication number: 20140314732Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).Type: ApplicationFiled: February 25, 2014Publication date: October 23, 2014Applicant: Lifebond Ltd.Inventor: Orahn PREISS-BLOOM
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Publication number: 20140193386Abstract: A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or tissue, such as lymph for example. The cross-linked albumin may optionally and preferably be applied as part of a bandage for example. In other embodiments, the present invention provides a method of enzymatically cross-linking globular proteins, by altering the structure of the protein to improve the accessibility of the protein to the cross-linking enzyme.Type: ApplicationFiled: February 17, 2014Publication date: July 10, 2014Applicant: LIFEBOND LTD.Inventors: Orahn PREISS-BLOOM, Guy TOMER, Nadav BRAMSON
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Patent number: 8722039Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.Type: GrantFiled: December 31, 2011Date of Patent: May 13, 2014Assignee: Lifebond Ltd.Inventors: Orahn Preiss-Bloom, Ishay Attar, Natalie Iram
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Patent number: 8703117Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).Type: GrantFiled: July 23, 2012Date of Patent: April 22, 2014Assignee: Lifebond Ltd.Inventors: Orahn Preiss Bloom, Ishay Attar, Natalie Iram, Chagai Komlos, Meir Haber
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Publication number: 20130131701Abstract: Patches comprising dry gelatin compositions and methods of use and manufacture thereof.Type: ApplicationFiled: August 5, 2011Publication date: May 23, 2013Applicant: LIFEBOND LTD.Inventors: Chagai Komlos, Guy Tomer, Maria Ziv, Orahn Preiss-Bloom, Thomas Bayer
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Publication number: 20130039899Abstract: Methods of application and devices thereof for tissue adhesives. The adhesives comprise a plurality of components which are provided separately but which are mixed together to form the adhesive. At least one component is a crosslinkable protein solution and at least one other component is a crosslinking material solution. The devices preferably include a mixing unit, which may include dynamic mixing elements, static mixing elements, or a combination of the two.Type: ApplicationFiled: April 20, 2011Publication date: February 14, 2013Applicant: LIFEBOND LTD.Inventors: Orahn Preiss-Bloom, Ishay Attar, Omer Shezifi, Yuval Shezifi, Golan Salman
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Patent number: 8367388Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).Type: GrantFiled: June 18, 2009Date of Patent: February 5, 2013Assignee: Lifebond Ltd.Inventors: Orahn Preiss Bloom, Ishay Attar, Natalie Iram, Chagai Komlos, Meir Haber
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Patent number: 8133484Abstract: An adhesive material comprising gelatin and a non-toxic cross-linking material such as transglutaminase. The adhesive material is useful for medical purposes as hemostatic products. The hemostatic products are useful for the treatment of wounded tissue.Type: GrantFiled: October 30, 2007Date of Patent: March 13, 2012Assignee: Lifebond LtdInventors: Orahn Preiss-Bloom, Ishay Attar
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Publication number: 20080213243Abstract: An adhesive material comprising gelatin and a non-toxic cross-linking material such as transglutaminase. The adhesive material is useful for medical purposes as hemostatic products. The hemostatic products are useful for the treatment of wounded tissue.Type: ApplicationFiled: October 30, 2007Publication date: September 4, 2008Applicant: LIFEBOND LTD.Inventors: Orahn Preiss-Bloom, Ishay Attar