Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on different methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumor.
Type:
Grant
Filed:
May 8, 2015
Date of Patent:
July 10, 2018
Assignee:
LifeCodexx AG
Inventors:
Sebastian Gromminger, Wera Hofmann, Hamed Said
Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumor.
Type:
Grant
Filed:
May 8, 2015
Date of Patent:
November 21, 2017
Assignee:
LifeCodexx AG
Inventors:
Sebastian Gromminger, Wera Hofmann, Hamed Said
Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumor.
Type:
Grant
Filed:
May 8, 2015
Date of Patent:
November 21, 2017
Assignee:
LifeCodexx AG
Inventors:
Sebastian Gromminger, Wera Hofmann, Hamed Said