Abstract: The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.
Type:
Grant
Filed:
March 28, 2008
Date of Patent:
December 11, 2012
Assignees:
Lifecord Inc.
Inventors:
Jung Keug Park, Sung Koo Kim, Suk Koo Lee, Young-Jin Kim, Doo-Hoon Lee, Ji-Hyun Lee, Hee-Hoon Yoon, Jae-Nam Ryu, Choon-Hyuck Kwon, Jeong-Kwon Noh, Hey-Jung Park
Abstract: Since the multipotent progenitor/stem cells isolated and cultured from the cord blood-derived mononuclear cells according to the method of the present invention are capable of differentiating into several types of cells including neurons, osteoblasts, myoblasts, endothelial cells, hepatocytes and dendritic cells, they can be effectively used for a cell therapy, a cell restoration technique or an organ production.
Type:
Grant
Filed:
January 31, 2005
Date of Patent:
October 19, 2010
Assignees:
Lifecord Inc.
Inventors:
Myoung Woo Lee, Young Jin Kim, Jeong Eun Choi, Mal Sook Yang, Young Joon Moon, Sun Kyung Kim, Hugh Chul Kim, Joon Seong Park, In Keun Jang
Abstract: Provided are an apparatus and a method of aseptically manufacturing cell-immobilizing capsules, the apparatus comprising a multi-nozzle assembly and a double mesh system for the washing and size-selection of the capsules, and thus, the production, washing, selection and recovery of the capsules can be easily conducted under an aseptic condition in an integrated fashion.
Abstract: The inventive method for the preparation of a dermal papilla tissue in accordance with the present invention makes it possible to form a quantity of the dermal papilla tissues having hair follicle inductive ability, and accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
Type:
Grant
Filed:
November 29, 2005
Date of Patent:
December 22, 2009
Assignees:
Lifecord Inc., Corp.
Inventors:
Jung-Keug Park, Doo-Hoon Lee, Hee-Hoon Yoon, Youn-Ho Shin, Young Jin Kim
Abstract: Lymphoid dendritic cells with immunophenotype CD8?+ can be produced by a method which comprises culturing human hematopoietic stem cells in a medium containing GM-CSF, followed by culturing in a medium containing IFN-?, the lymphoid dendritic cells being useful in various immunotherapies.