Abstract: The following description concerns a therapeutic method for the treatment of diseases connected with the modulation of the cannabinoid peripheral receptor, comprising administering amidic derivatives of mono and bicarboxylic acids with aminoalcohols or arninoethers selectively active on said receptor.
Type:
Grant
Filed:
September 30, 1997
Date of Patent:
November 23, 1999
Assignee:
Lifegroup S.p.A.
Inventors:
Francesco Della Valle, Alberta Leon, Gabriele Marcolongo, Silvana Lorenzi
Abstract: The use of N-acyl derivatives of aminoalcohols with mono- and di-carboxylic acids for the prevention and treatment of diseases connected with hyper and prolonged excitation by excitatory amino acids is described.
Type:
Grant
Filed:
September 23, 1996
Date of Patent:
July 20, 1999
Assignee:
Lifegroup S.P.A.
Inventors:
Francesco Della Valle, Alberta Leon, Silvana Lorenzi
Abstract: Compositions having high bioadhesion, mucoadhesion and visoelasticity, containing mixtures of synthetic polymers, such as polyvinyl alcohol and Polycarbophil, and of biopolymers, such as alginic acid, hyaluronic acid and dermatan sulfate, useful in the treatment of skin and mucosal tissues dryness and dehydration, and suitables as vehicles for active ingredients in percutaneous absorption.
Type:
Grant
Filed:
April 22, 1997
Date of Patent:
March 2, 1999
Assignee:
Lifegroup S.p.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Roberto Cerini, Gabriele Marcolongo
Abstract: Described herein are biotin amides which are able to control glucidic metabolism under dysmetabolic conditions and relative therapeutical compositions for the treatment of insulin-independent diabetes, insulin-dependent diabetes and relative complicating diseases, such as peripheral neuropathies and other associated chronic invalidating disorders.
Type:
Grant
Filed:
March 28, 1997
Date of Patent:
September 29, 1998
Assignee:
Lifegroup S.p.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Gabriele Marcolongo, Lauro Galzigna
Abstract: Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging from 2000 to 7000, combined with suitable excipients and/or diluents.
Type:
Grant
Filed:
April 18, 1994
Date of Patent:
December 9, 1997
Assignee:
Lifegroup S.p.A.
Inventors:
Francesco della Valle, Roberto Cerini, Gabriella Calderini
Abstract: Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging from 2000 to 7000, combined with suitable excipients and/or diluents.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
December 2, 1997
Assignee:
LifeGroup S.p.A.
Inventors:
Francesco della Valle, Roberto Cerini, Gabriella Calderini
Abstract: Aminoalcohols N-acyl derivatives useful in the prevention and in the treatment of mammalian pathologies induced by mast cell degranulation in consequence of peripheral nerve noxae.
Type:
Grant
Filed:
October 21, 1994
Date of Patent:
October 21, 1997
Assignee:
Lifegroup S.P.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Federica Della Valle
Abstract: N-acyl derivatives of aminoalcohols with bicarboxylic or tricarboxylic acids able to modulate the degranulation process consequent to the mast cells activation in inflammatory processes caused by supramaximal stimuli of neurogenic and immunogenic origin.
Type:
Grant
Filed:
June 24, 1994
Date of Patent:
April 8, 1997
Assignee:
Lifegroup S.p.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Gabriele Marcolongo
Abstract: Traumatic acid salts, wherein B is a cation selected from:a) a quaternary ammonium,b) a cation of a linear or branched C.sub.1 -C.sub.20 mono-, di- or trialkanolamine,c) a cation of a biologically active primary, secondary or tertiary amine,d) silver or zinc cation,and relative pharmaceutical compositions administrable by topical or parenteral route For the therapeutic treatment of cutaneous pathologies in which it is important to associate an a bacteriostatic, antibiotic, antifungal or an antiviral activity, to the cicatrizant effect, typical of traumatic acid.
Type:
Grant
Filed:
November 19, 1993
Date of Patent:
October 22, 1996
Assignee:
Lifegroup S.p.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Gabriele Marcolongo
Abstract: Salts of biotin are described with alkanolamines and the respective water soluble therapeutical compositions, suitable to be orally, parenterally and topically administered.The compositions above are particularly suitable for the treatment of the vitamin H deficiency, having a dermatologic manifestation, for the treatment of the insufficiency in multiple carboxylase enzymes, for the treatment of dermatologic phatologies, like the seborrheal dermatitis in the newborn, and for the treatment of diabetic neuropathies.
Type:
Grant
Filed:
February 22, 1994
Date of Patent:
August 27, 1996
Assignee:
Lifegroup, S.p.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Gabriella Calderini
Abstract: N-acyl-derivatives of hydroxyamines suitable for the therapeutic treatment of pathologies characterized by degranulation of mast cells caused by a neurogenic and/or immunogenic hyperstimulation.
Type:
Grant
Filed:
November 8, 1993
Date of Patent:
April 9, 1996
Assignee:
Lifegroup S.P.A.
Inventors:
Francesco della Valle, Silvana Lorenzi, Jacobus C. J. J. Samson, Federica della Valle
Abstract: Hydroxyamines N-acyl derivatives with benzochroman or 2,3-dihydrobenzofuran carboxy acids and relative pharmaceutical composition for the therapeutic treatment of those CNS, vascular, cardiovascular, dermatologic and ophthalmic pathologies wherein it is important to associate an inflammatory modulation effect to an antioxidant activity.
Type:
Grant
Filed:
December 29, 1993
Date of Patent:
January 2, 1996
Assignee:
LifeGroup S.p.A.
Inventors:
Francesco Della Valle, Silvana Lorenzi, Gabriele Marcolongo