Patents Assigned to Lifenet Health
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Patent number: 11969354Abstract: The invention relates to medical implants, including spinal implants and bone grafts, for fixation and integration with hard tissue. The bone medical implants include at least one rotational fixation mechanism that further includes or is attached to one or more sharp protrusions configured to penetrate and become lodged into hard tissue to provide support and positional stability. Such support is useful to ensure that the spinal bone graft may be used without additional stabilizing or anchoring structures, such as supporting plates or screws.Type: GrantFiled: August 12, 2021Date of Patent: April 30, 2024Assignee: LifeNet HealthInventors: Jingsong Chen, Dennis Phelps, Andy T. Pritchard, Nathan Kemper, Thomas Brewer
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Publication number: 20240099856Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.Type: ApplicationFiled: December 4, 2023Publication date: March 28, 2024Applicant: LifeNet HealthInventors: Mark Evans, Dennis Phelps, Jingsong Chen
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Publication number: 20240009352Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.Type: ApplicationFiled: September 20, 2023Publication date: January 11, 2024Applicant: LifeNet HealthInventors: Silvia Chen, Grant Cleavenger, Dennis Phelps, Breanne Gjurich, Evans Wralstad, Austin Johnson, Alana Sampson, Adam Entsminger, Jingsong Chen
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Patent number: 11865015Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.Type: GrantFiled: July 21, 2022Date of Patent: January 9, 2024Assignee: LifeNet HealthInventors: Mark Evans, Dennis Phelps, Jingsong Chen
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Publication number: 20230363374Abstract: An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.Type: ApplicationFiled: July 25, 2023Publication date: November 16, 2023Applicant: LifeNet HealthInventors: Silvia Chen, Austin Johnson, Roberto Bracone
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Publication number: 20230301683Abstract: The present invention provides a cannula for delivering a tissue graft to a treatment site. The cannula comprises a distal end, a proximal end, a bore formed by an interior surface of the cannula, extending from the distal end to the proximal end and having a diameter, and a tissue graft inside the bore and in contact with the interior surface. The tissue graft may be released from the cannula at the distal end to the treatment site. The tissue graft may have a final loading pressure of 20-200 psi. Also provided is a delivery system comprising the cannula and a delivery device. Further provided are methods for delivering a tissue graft in a cannula to a treatment site and methods for preparing a cannula loaded with the tissue graft.Type: ApplicationFiled: August 10, 2021Publication date: September 28, 2023Applicant: LifeNet HealthInventors: Adam Entsminger, Cheryl Berger, Michael Masters, Kevin Shores, Erich Lohmann, Jingsong Chen
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Patent number: 11730163Abstract: An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.Type: GrantFiled: January 6, 2021Date of Patent: August 22, 2023Assignee: LifeNet HealthInventors: Silvia Chen, Austin Johnson, Roberto Bracone
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Publication number: 20230257696Abstract: The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.Type: ApplicationFiled: April 14, 2023Publication date: August 17, 2023Applicant: LifeNet HealthInventors: Michael Francis, Silvia Chen, Erick Breathwaite, Rudy Rodriguez, Alan Smith, Alexander Huber, Jung Bok Lee
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Publication number: 20230158205Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.Type: ApplicationFiled: January 6, 2023Publication date: May 25, 2023Applicant: LifeNet HealthInventors: Michael Francis, Rudy Rodriquez, Nathan Kemper, Silvia Chen
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Patent number: 11655448Abstract: The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.Type: GrantFiled: May 27, 2016Date of Patent: May 23, 2023Assignee: LifeNet HealthInventors: Michael Francis, Silvia Chen, Erick Breathwaite, Rudy Rodriguez, Alan Smith, Alexander Huber, Jung Bok Lee
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Publication number: 20230101122Abstract: The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.Type: ApplicationFiled: December 5, 2022Publication date: March 30, 2023Applicant: LifeNet HealthInventors: Jung Bok Lee, Angela Murchison, Edward LeCluyse, Jingsong Chen
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Publication number: 20230079283Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.Type: ApplicationFiled: November 18, 2022Publication date: March 16, 2023Applicant: LifeNet HealthInventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
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Patent number: 11576999Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.Type: GrantFiled: August 7, 2020Date of Patent: February 14, 2023Assignee: LifeNet HealthInventors: Michael Francis, Rudy Rodriquez, Nathan Kemper, Silvia Chen
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Patent number: 11533906Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.Type: GrantFiled: November 23, 2020Date of Patent: December 27, 2022Assignee: LIFENET HEALTHInventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
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Patent number: 11535827Abstract: The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.Type: GrantFiled: September 22, 2018Date of Patent: December 27, 2022Assignee: LifeNet HealthInventors: Jung Bok Lee, Angela Murchison, Edward LeCluyse, Jingsong Chen
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Publication number: 20220372438Abstract: The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.Type: ApplicationFiled: July 22, 2022Publication date: November 24, 2022Applicant: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen
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Publication number: 20220354666Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.Type: ApplicationFiled: July 21, 2022Publication date: November 10, 2022Applicant: LifeNet HealthInventors: Mark Evans, Dennis Phelps, Jingsong Chen
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Patent number: D968608Type: GrantFiled: August 12, 2019Date of Patent: November 1, 2022Assignee: LifeNet HealthInventor: Andrew Pritchard
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Patent number: D968609Type: GrantFiled: September 12, 2019Date of Patent: November 1, 2022Assignee: LifeNet HealthInventor: Andrew Pritchard
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Patent number: D989964Type: GrantFiled: July 5, 2022Date of Patent: June 20, 2023Assignee: LifeNet HealthInventor: Andrew Pritchard