Abstract: A rapid vascular drug delivery device, system and method is provided having a releasibly extending and retracting needle necessary for injecting and withdrawing fluid into and from a physiological or non-physiological cavity. Accordingly, the needle can be releasibly extended with sufficient momentum at a point of impact to penetrate a hard substance such as bone. The needle is slideably placed within an aperture configured at the forward end of a main housing, wherein a trigger needle can be arranged proximate to the forward end in order to detect tissue thickness or bone depth necessary for ensuring accurate placement of the bone-piercing needle within the bone marrow. The needle can receive fluids interspersed by parallel-placed or series-placed fluid containers configured within the main housing.