Patents Assigned to Lifesensors, Inc.
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Patent number: 9382574Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.Type: GrantFiled: August 26, 2013Date of Patent: July 5, 2016Assignee: Lifesensors, Inc.Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
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Synthetic protease substrates, assay methods using such substrates and kits for practicing the assay
Patent number: 8697376Abstract: Synthetic protease substrates and methods which facilitate the identification of substrates of a protease, particularly ubiquitin, ubiquitin-like, or proteasome protein are provided.Type: GrantFiled: February 3, 2011Date of Patent: April 15, 2014Assignee: Lifesensors, INc.Inventors: Tauseef R. Butt, Joseph Manimala, Mabel A. Cejas, James E. Strickler, William Kingsbury, Jian Wu -
Patent number: 8691958Abstract: Methods for enhancing expression levels, secretion, and purification of heterologous fusion proteins in a host cell are disclosed.Type: GrantFiled: December 28, 2007Date of Patent: April 8, 2014Assignees: Progenra, Inc., Lifesensors, Inc.Inventors: Tauseef R. Butt, Tadas Panavas, Amolkumar Karwa, Raymond J. Peroutka, Jeffrey G. Marblestone
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Publication number: 20140072992Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.Type: ApplicationFiled: August 26, 2013Publication date: March 13, 2014Applicants: Progenra, Inc., Lifesensors, Inc.Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
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Patent number: 8518660Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.Type: GrantFiled: June 24, 2011Date of Patent: August 27, 2013Assignees: Lifesensors, Inc., Progenra, Inc.Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
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Patent number: 8440449Abstract: Recombinant Saccharomyces cerevisiae produced by transformation with heterologous polynucleotide sequences coding for xylulokinase (XKS) from Yersinia pestis and xylose isomerase (XI) are capable of xylose utilization. The transformants express these heterologous polynucleotides at a sufficient functional level to grow aerobically on xylose as the sole carbon source. Further transformation of the recombinant yeasts to overexpress one or more of the S cerevisiae genes PIP2, IMG2, MAK5, VPS9, COX10, ALE1, CDC7, and MMS4, permits the yeast to grow anaerobically on xylose as the sole carbon source. When grown under anaerobic conditions on a culture medium comprising both glucose and xylose, the transformed yeast exhibit increased ethanol productivity, with the yeast growing on the xylose to increase their biomass and fermenting the glucose to ethanol.Type: GrantFiled: September 28, 2009Date of Patent: May 14, 2013Assignees: The United States of America, as represented by the Secretary of Agriculture, LifeSensors, Inc.Inventors: Stephen R. Hughes, Tauseef R. Butt
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Publication number: 20120065106Abstract: Methods for enhancing expression levels, secretion, and purification of heterologous fusion proteins in a host cell are disclosed.Type: ApplicationFiled: December 28, 2007Publication date: March 15, 2012Applicant: LIFESENSORS, INC.Inventors: Tauseef R. Butt, Tadas Panavas, Amolkumar Karwa, Raymond J. Peroutka, Jeffrey G. Marblestone
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Patent number: 8119369Abstract: The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino acids, unlike wild-type proteins which always are translated from mRNA with methionine at the N-terminus.Type: GrantFiled: December 30, 2005Date of Patent: February 21, 2012Assignee: Lifesensors, Inc.Inventors: Xun Zuo, David E. Sterner, Tauseef R. Butt
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Patent number: 7820384Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.Type: GrantFiled: February 28, 2006Date of Patent: October 26, 2010Assignee: Lifesensors, Inc.Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, MÃchael P. Malakhov, Oxana A. Malakhova
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Patent number: 7655413Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.Type: GrantFiled: June 28, 2004Date of Patent: February 2, 2010Assignee: Lifesensors, Inc.Inventors: Tauseef R. Butt, Oxana A. Malakhova, Michael P. Malakhov
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Publication number: 20100021987Abstract: The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino acids, unlike wild-type proteins which always are translated from mRNA with methionine at the N-terminus.Type: ApplicationFiled: December 30, 2005Publication date: January 28, 2010Applicant: LIFESENSORS, INC.Inventors: Xun Zuo, David E. Sterner, Tauseef R. Butt
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Patent number: 7220576Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.Type: GrantFiled: March 14, 2003Date of Patent: May 22, 2007Assignee: Lifesensors, Inc.Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
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Patent number: 7083941Abstract: A yeast based transactivation assay for gender sorting is disclosed.Type: GrantFiled: April 23, 2002Date of Patent: August 1, 2006Assignee: Lifesensors, Inc.Inventors: Tauseef Butt, Hiep Tuan Tran
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Patent number: 7060461Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.Type: GrantFiled: January 7, 2003Date of Patent: June 13, 2006Assignee: Lifesensors, Inc.Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
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Patent number: 7037656Abstract: A yeast-based system and methods of use therefore are provided for identifying new molecules which activate nuclear receptors in a ligand-dependent fashion. In a preferred embodiment, a method is provided utilizing ecdysone receptor, USP and GRIP I encoding expression vectors which may be used to advantage for screening new and useful insecticidal compounds, detecting insecticidal residues as well as to regulate expression of a gene of interest in a host in a ligand-dependent manner.Type: GrantFiled: February 20, 2001Date of Patent: May 2, 2006Assignee: Lifesensors, Inc.Inventors: Hiep Tuan Tran, Salam Shaaban, Hossein Askari, Michael Schwartz, Tauseef Butt
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Patent number: 6113553Abstract: The present invention relates to an apparatus for monitoring the intracranial pressure of a patient. The apparatus includes an implantable sensor implanted in the skull of a patient. The implantable sensor senses pressure and outputs a signal indicative of the pressure in the patient's skull. The apparatus further includes a probe receiving the signal output by the implantable sensor when the probe is positioned near the implantable sensor. The probe outputs a signal indicative of the pressure sensed by the implantable sensor. An interrogation circuit is provided for receiving the signal output by the probe and automatically outputting a digital signal proportional to the pressure sensed by the implantable sensor.Type: GrantFiled: August 18, 1998Date of Patent: September 5, 2000Assignee: LifeSensors, Inc.Inventor: John G. Chubbuck