Patents Assigned to Lifesensors, Inc.
  • Di- and poly-ubiquitin deubiquitinase substrates and uses thereof
    Patent number: 9382574
    Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: July 5, 2016
    Assignee: Lifesensors, Inc.
    Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
  • Synthetic protease substrates, assay methods using such substrates and kits for practicing the assay
    Patent number: 8697376
    Abstract: Synthetic protease substrates and methods which facilitate the identification of substrates of a protease, particularly ubiquitin, ubiquitin-like, or proteasome protein are provided.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: April 15, 2014
    Assignee: Lifesensors, INc.
    Inventors: Tauseef R. Butt, Joseph Manimala, Mabel A. Cejas, James E. Strickler, William Kingsbury, Jian Wu
  • Methods and compositions for enhanced protein expression and purification
    Patent number: 8691958
    Abstract: Methods for enhancing expression levels, secretion, and purification of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: April 8, 2014
    Assignees: Progenra, Inc., Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Tadas Panavas, Amolkumar Karwa, Raymond J. Peroutka, Jeffrey G. Marblestone
  • Di- and Poly-Ubiquitin Deubiquitinase Substrates and Uses Thereof
    Publication number: 20140072992
    Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.
    Type: Application
    Filed: August 26, 2013
    Publication date: March 13, 2014
    Applicants: Progenra, Inc., Lifesensors, Inc.
    Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
  • Di- and poly-ubiquitin deubiquitinase substrates and uses thereof
    Patent number: 8518660
    Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: August 27, 2013
    Assignees: Lifesensors, Inc., Progenra, Inc.
    Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
  • Transformed engineered for xylose utilization
    Patent number: 8440449
    Abstract: Recombinant Saccharomyces cerevisiae produced by transformation with heterologous polynucleotide sequences coding for xylulokinase (XKS) from Yersinia pestis and xylose isomerase (XI) are capable of xylose utilization. The transformants express these heterologous polynucleotides at a sufficient functional level to grow aerobically on xylose as the sole carbon source. Further transformation of the recombinant yeasts to overexpress one or more of the S cerevisiae genes PIP2, IMG2, MAK5, VPS9, COX10, ALE1, CDC7, and MMS4, permits the yeast to grow anaerobically on xylose as the sole carbon source. When grown under anaerobic conditions on a culture medium comprising both glucose and xylose, the transformed yeast exhibit increased ethanol productivity, with the yeast growing on the xylose to increase their biomass and fermenting the glucose to ethanol.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: May 14, 2013
    Assignees: The United States of America, as represented by the Secretary of Agriculture, LifeSensors, Inc.
    Inventors: Stephen R. Hughes, Tauseef R. Butt
  • Methods and Compositions for Enhanced Protein Expression and Purification
    Publication number: 20120065106
    Abstract: Methods for enhancing expression levels, secretion, and purification of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: December 28, 2007
    Publication date: March 15, 2012
    Applicant: LIFESENSORS, INC.
    Inventors: Tauseef R. Butt, Tadas Panavas, Amolkumar Karwa, Raymond J. Peroutka, Jeffrey G. Marblestone
  • Human SUMO-3 for enhancing protein expression
    Patent number: 8119369
    Abstract: The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino acids, unlike wild-type proteins which always are translated from mRNA with methionine at the N-terminus.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: February 21, 2012
    Assignee: Lifesensors, Inc.
    Inventors: Xun Zuo, David E. Sterner, Tauseef R. Butt
  • Methods and compositions for protein expression and purification
    Patent number: 7820384
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: October 26, 2010
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Míchael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for enhanced protein expression and purification
    Patent number: 7655413
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 2, 2010
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Oxana A. Malakhova, Michael P. Malakhov
  • Compositions, Methods, and Kits for Enhancing Protein Expression
    Publication number: 20100021987
    Abstract: The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino acids, unlike wild-type proteins which always are translated from mRNA with methionine at the N-terminus.
    Type: Application
    Filed: December 30, 2005
    Publication date: January 28, 2010
    Applicant: LIFESENSORS, INC.
    Inventors: Xun Zuo, David E. Sterner, Tauseef R. Butt
  • Methods and compositions for protein expression and purification
    Patent number: 7220576
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: May 22, 2007
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • Compositions and methods for gender sorting
    Patent number: 7083941
    Abstract: A yeast based transactivation assay for gender sorting is disclosed.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: August 1, 2006
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef Butt, Hiep Tuan Tran
  • Methods and compositions for protein expression and purification
    Patent number: 7060461
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: June 13, 2006
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for identifying ligands for nuclear receptors
    Patent number: 7037656
    Abstract: A yeast-based system and methods of use therefore are provided for identifying new molecules which activate nuclear receptors in a ligand-dependent fashion. In a preferred embodiment, a method is provided utilizing ecdysone receptor, USP and GRIP I encoding expression vectors which may be used to advantage for screening new and useful insecticidal compounds, detecting insecticidal residues as well as to regulate expression of a gene of interest in a host in a ligand-dependent manner.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: May 2, 2006
    Assignee: Lifesensors, Inc.
    Inventors: Hiep Tuan Tran, Salam Shaaban, Hossein Askari, Michael Schwartz, Tauseef Butt
  • Telemetric intracranial pressure monitoring system
    Patent number: 6113553
    Abstract: The present invention relates to an apparatus for monitoring the intracranial pressure of a patient. The apparatus includes an implantable sensor implanted in the skull of a patient. The implantable sensor senses pressure and outputs a signal indicative of the pressure in the patient's skull. The apparatus further includes a probe receiving the signal output by the implantable sensor when the probe is positioned near the implantable sensor. The probe outputs a signal indicative of the pressure sensed by the implantable sensor. An interrogation circuit is provided for receiving the signal output by the probe and automatically outputting a digital signal proportional to the pressure sensed by the implantable sensor.
    Type: Grant
    Filed: August 18, 1998
    Date of Patent: September 5, 2000
    Assignee: LifeSensors, Inc.
    Inventor: John G. Chubbuck