Patents Assigned to LIGATURE THERAPEUTICS PTE. LTD.
  • Therapeutic compounds and methods of use thereof
    Patent number: 11548866
    Abstract: There are provided new inhibitors of MDM2. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by MDM2 over-expression or malfunction.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: January 10, 2023
    Assignee: LIGATURE THERAPEUTICS PTE. LTD.
    Inventors: Rajavel Srinivasan, Wei Hung
  • Therapeutic compounds and methods of use thereof
    Patent number: 11504381
    Abstract: There are provided new heterobifunctional agents designed to mediate formation of protein-protein dimers and promote ubiquitination of a protein of interest component of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: November 22, 2022
    Assignee: LIGATURE THERAPEUTICS PTE. LTD.
    Inventors: Rajavel Srinivasan, Wei Hung