Patents Assigned to LightLab Imaging, Inc.
  • Publication number: 20240115141
    Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
    Type: Application
    Filed: November 30, 2023
    Publication date: April 11, 2024
    Applicant: LightLab Imaging, Inc,
    Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
  • Publication number: 20240099590
    Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
    Type: Application
    Filed: November 29, 2023
    Publication date: March 28, 2024
    Applicant: LightLab Imaging, Inc.
    Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
  • Publication number: 20240099591
    Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
    Type: Application
    Filed: November 30, 2023
    Publication date: March 28, 2024
    Applicant: LightLab Imaging, Inc.
    Inventors: Joseph M. Schmitt, Joel M. Friedman, Christopher Petroff, Amr Elbasiony
  • Patent number: 11923067
    Abstract: In part, the invention relates to a method for sizing a stent for placement in a vessel. In one embodiment, the method includes the steps of: dividing the vessel into a plurality of segments, each segment being defined as the space between branches of the vessel; selecting a starting point that appears to have substantially no disease; defining the diameter at this point to be the maximum diameter; calculating the maximal diameter of the next adjacent segment according to a power law; measuring the actual diameter of the next adjacent segment; selecting either the calculated maximum diameter or the measured maximum diameter depending upon which diameter is larger; using the selected maximum diameter to find the maximum diameter of this next segment; iteratively proceeding until the entire length of the vessel is examined; and selecting a stent in response to the diameters of the end proximal and distal segments.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: March 5, 2024
    Assignee: LightLab Imaging, Inc.
    Inventors: Joseph M. Schmitt, Hiram Bezerra, Christopher Petroff, Ajay Gopinath
  • Publication number: 20240057870
    Abstract: In part, the disclosure relates to method of displaying a representation of an artery. The method may include storing an intravascular image dataset in a memory device of a diagnostic imaging system, the intravascular image dataset generated in response to intravascular imaging of a segment of an artery; automatically detecting lumen boundary of the segment on a per frame basis; automatically detecting EEL and displaying a stent sizing workflow. In part, the disclosure also relates to automatically detecting one or more regions of calcium relative to lumen boundary of the segment; calculating an angular or circumferential measurement of detected calcium for one or more frames; calculating a calcium thickness of detected calcium for one or more frames; and displaying the calcium thickness and the angular or circumferential measurement of detected calcium for a first frame of the one or more frames.
    Type: Application
    Filed: October 31, 2023
    Publication date: February 22, 2024
    Applicant: LightLab Imaging, Inc.
    Inventors: Ajay Gopinath, Mark Hoeveler
  • Publication number: 20240046476
    Abstract: The present disclosure provides systems and methods to receiving OCT or IVUS image data frames to output one or more representations of a blood vessel segment. The image data frames may be stretched and/or aligned using various windows or bins or alignment features. Arterial features, such as the calcium burden, may be detected in each of the image data frames. The arterial features may be scored. The score may be a stent under-expansion risk. The representation may include an indication of the arterial features and their respective score. The indication may be a color coded indication.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 8, 2024
    Applicant: LightLab Imaging, Inc.
    Inventors: Gregory Patrick Amis, Ajay Gopinath, Mark Hoeveler
  • Patent number: 11892291
    Abstract: Aspects of the disclosure relate to systems, methods, and algorithms to perform wavenumber linearization and dispersion correction in optical systems without the need for hardware modifications, empirical adjustments, precise mirror alignment, and which can be conducted at low computational costs and in real-time. A one-time calibration process can generate spectra or calibration criteria, including wavenumber-linearization criteria, dispersion correction, and spectral flattening spectra, which can be used to correct an optical coherence tomogram in real time.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: February 6, 2024
    Assignee: LightLab Imaging, Inc.
    Inventors: Chih-Hao Liu, Steven M. Stromski
  • Publication number: 20240036720
    Abstract: In part, the disclosure relates to intravascular data collection systems and the software-based visualization and display of intravascular data relating to detected side branches and side branch obstruction. An estimate of side branch diameter can be made based on a vessel profile or a maximum diameter of a vessel at a distal and proximal location relative to the side branch. A amount of side branch obstruction may be determined by comparing an observed side branch diameter with in the image data with the estimated side branch diameter. In addition, an amount of blood flow obstruction may also be determined.
    Type: Application
    Filed: August 15, 2023
    Publication date: February 1, 2024
    Applicant: LightLab Imaging, Inc.
    Inventors: Ajay Gopinath, Denis Dion, Christopher E. Griffin, Desmond Adler
  • Publication number: 20240032894
    Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for detecting a delivery catheter using intravascular data. In one embodiment, the delivery catheter is used to position the intravascular data collection probe. The probe can collect data suitable for generating one or more representations of a blood vessel with respect to which the delivery catheter can be detected.
    Type: Application
    Filed: October 5, 2023
    Publication date: February 1, 2024
    Applicant: LightLab Imaging, Inc.
    Inventors: James G. Peterson, Christopher E. Griffin, Sonal Ambwani
  • Patent number: 11883107
    Abstract: In part, the disclosure relates to determining a stent deployment location and other parameters using blood vessel data. Stent deployment can be planned such that the amount of blood flow restored from stenting relative to an unstented vessel increases one or more metrics. An end user can specify one or more stent lengths, including a range of stent lengths. In turn, diagnostic tools can generate candidate virtual stents having lengths within the specified range suitable for placement relative to a vessel representation. Blood vessel distance values such as blood vessel diameter, radius, area values, chord values, or other cross-sectional, etc. its length are used to identify stent landing zones. These tools can use or supplement angiography data and/or be co-registered therewith. Optical imaging, ultrasound, angiography or other imaging modalities are used to generate the blood vessel data.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 30, 2024
    Assignee: LightLab Imaging, Inc.
    Inventor: Ajay Gopinath
  • Publication number: 20230414176
    Abstract: A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.
    Type: Application
    Filed: September 13, 2023
    Publication date: December 28, 2023
    Applicant: LightLab Imaging, Inc.
    Inventors: Joseph M. Schmitt, Chenyang Xu
  • Publication number: 20230414314
    Abstract: In one embodiment, the disclosure relates to a probe that a cylindrical marker band defining an inner surface, an outer surface, a first end and a second end and having a band length, the inner surface defining a marker band bore, the cylindrical marker band includes a radiopaque material; a molded unitary lens defining an elongate optical fiber receiving section having a fiber section length and a beam directing surface, wherein the fiber section length and the band length overlap along an overlap distance; and an optical fiber, wherein a first section of the optical fiber is disposed in the optical fiber receiving section, wherein a portion of the first section of the optical fiber is disposed within the marker band bore.
    Type: Application
    Filed: September 8, 2023
    Publication date: December 28, 2023
    Applicant: LightLab Imaging, Inc.
    Inventors: James Booker, David Ellman, Douglas Tatosian, Charles Milne
  • Patent number: 11850089
    Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for detecting a delivery catheter using intravascular data. In one embodiment, the delivery catheter is used to position the intravascular data collection probe. The probe can collect data suitable for generating one or more representations of a blood vessel with respect to which the delivery catheter can be detected.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: December 26, 2023
    Assignee: LightLab Imaging, Inc.
    Inventors: James G. Peterson, Christopher E. Griffin, Sonal Ambwani
  • Publication number: 20230389799
    Abstract: In part, the disclosure relates to method of displaying a representation of an artery. The method may include storing an intravascular image dataset in a memory device of a diagnostic imaging system, the intravascular image dataset generated in response to intravascular imaging of a segment of an artery; automatically detecting lumen boundary of the segment on a per frame basis; automatically detecting EEL and displaying a stent sizing workflow. In part, the disclosure also relates to automatically detecting one or more regions of calcium relative to lumen boundary of the segment; calculating an angular or circumferential measurement of detected calcium for one or more frames; calculating a calcium thickness of detected calcium for one or more frames; and displaying the calcium thickness and the angular or circumferential measurement of detected calcium for a first frame of the one or more frames.
    Type: Application
    Filed: August 24, 2023
    Publication date: December 7, 2023
    Applicant: LightLab Imaging, Inc.
    Inventors: Ajay Gopinath, Mark Hoeveler
  • Patent number: 11819309
    Abstract: In part, the disclosure relates to method of displaying a representation of an artery. The method may include storing an intravascular image dataset in a memory device of a diagnostic imaging system, the intravascular image dataset generated in response to intravascular imaging of a segment of an artery; automatically detecting lumen boundary of the segment on a per frame basis; automatically detecting EEL and displaying a stent sizing workflow. In part, the disclosure also relates to automatically detecting one or more regions of calcium relative to lumen boundary of the segment; calculating an angular or circumferential measurement of detected calcium for one or more frames; calculating a calcium thickness of detected calcium for one or more frames; and displaying the calcium thickness and the angular or circumferential measurement of detected calcium for a first frame of the one or more frames.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: November 21, 2023
    Assignee: LightLab Imaging, Inc.
    Inventors: Ajay Gopinath, Mark Hoeveler
  • Patent number: 11793462
    Abstract: A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: October 24, 2023
    Assignee: LightLab Imaging, Inc.
    Inventors: Joseph M. Schmitt, Chenyang Xu
  • Publication number: 20230326032
    Abstract: In part, the disclosure relates to methods, and systems suitable for evaluating image data from a patient on a real time or substantially real time basis using machine learning (ML) methods and systems. Systems and methods for improving diagnostic tools for end users such as cardiologists and imaging specialists using machine learning techniques applied to specific problems associated with intravascular images that have polar representations. Further, given the use of rotating probes to obtain image data for OCT, IVUS, and other imaging data, dealing with the two coordinate systems associated therewith creates challenges. The present disclosure addresses these and numerous other challenges relating to solving the problem of quickly imaging and diagnosis a patient such that stenting and other procedures may be applied during a single session in the cath lab.
    Type: Application
    Filed: June 1, 2023
    Publication date: October 12, 2023
    Applicant: LightLab Imaging, Inc.
    Inventors: Shimin Li, Ajay Gopinath, Kyle Savidge
  • Publication number: 20230306620
    Abstract: The disclosure relates to methods of providing live x-ray images such as fluoroscopic images in combination with reference information co-registered angiography frames that are motion corrected in real time. In part, the disclosure describes an improvement on the existing workflow where the user must remember where the vessel features from OCT are and use a reference frame to estimate the location of desired stent placement. Disclosed herein are methods to correlate the live imaging feed and the reference angiography image such that the user may dynamically zoom and pan the live imaging feed and the reference angiography image.
    Type: Application
    Filed: March 23, 2023
    Publication date: September 28, 2023
    Applicant: LightLab Imaging, Inc.
    Inventors: Angela Zhang, Shimin Li, Robert Steinbrecher, Jack Fince, Paul Gervasio
  • Patent number: 11768593
    Abstract: In part, the disclosure relates to intravascular data collection systems and the software-based visualization and display of intravascular data relating to detected side branches and side branch obstruction. An estimate of side branch diameter can be made based on a vessel profile or a maximum diameter of a vessel at a distal and proximal location relative to the side branch. A amount of side branch obstruction may be determined by comparing an observed side branch diameter with in the image data with the estimated side branch diameter. In addition, an amount of blood flow obstruction may also be determined.
    Type: Grant
    Filed: February 17, 2022
    Date of Patent: September 26, 2023
    Assignee: LightLab Imaging, Inc.
    Inventors: Ajay Gopinath, Denis Dion, Christopher E. Griffin, Desmond Adler
  • Publication number: 20230280153
    Abstract: Aspects of the disclosure provide for automated self-inspection by an OCT imaging engine or device, to identify and resolve failures or inefficiencies in the hardware and/or software of the system or device during imaging. An OCT imaging engine can include a catheter connection check system for checking the quality of a physical connection point between a catheter and other components of an OCT imaging device or system. In some examples, the OCT imaging engine includes a self-inspection engine implemented to perform routine self-inspection by using a reference reflector internal to the OCT imaging engine to generate system performance data. The OCT imaging engine can use the system performance data to periodically search for and resolve failures or inefficiencies in the system. The OCT imaging engine can perform a self-calibration process to perform k-linearization and/or correct for chromatic dispersion using mirror measurements collected from an internal reference reflector.
    Type: Application
    Filed: March 2, 2023
    Publication date: September 7, 2023
    Applicant: LightLab Imaging, Inc.
    Inventors: Steven M. Stromski, Chih-Hao Liu