Patents Assigned to Lightship Medical Limited
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Publication number: 20180306802Abstract: A method of quantifying the amount of glucose in a sample is provided herein that may further comprise an interferent such as mannitol. At least two measurements are obtained using measurement methods that differ in their sensitivity to the amount of interferent in the sample, thus enabling the results to be compared to determine whether any interferent is present in the sample.Type: ApplicationFiled: January 26, 2018Publication date: October 25, 2018Applicant: Lightship Medical LimitedInventors: Barry Colin Crane, William Paterson, Nicholas Paul Barwell, Peter Edgley
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Patent number: 9970940Abstract: An optical glucose sensor for detecting and/or quantifying the amount of glucose in a sample comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a glucose-permeable barrier layer comprising a semi-permeable membrane having pores and a hydrophilic polymer within the pores of the semi-permeable membrane, the barrier layer overlying at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through the glucose-permeable barrier layer, and an ROS-quenching agent is present in the sensing region and/or the glucose-permeable barrier layer.Type: GrantFiled: August 8, 2012Date of Patent: May 15, 2018Assignee: Lightship Medical LimitedInventors: Barry Crane, William Paterson, Nicholas Paul Barwell, Bruce Culbert
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Patent number: 9797909Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.Type: GrantFiled: September 26, 2016Date of Patent: October 24, 2017Assignee: Lightship Medical LimitedInventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
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Patent number: 9476886Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through said barrier layer.Type: GrantFiled: January 26, 2015Date of Patent: October 25, 2016Assignee: Lightship Medical LimitedInventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
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Patent number: 9222941Abstract: The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.Type: GrantFiled: January 10, 2012Date of Patent: December 29, 2015Assignee: Lightship Medical LimitedInventors: Nicholas Paul Barwell, Tony James
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Patent number: 9151764Abstract: An optical glucose sensor comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a hydrophilic, polymeric, glucose-permeable barrier layer which is provided on at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through said barrier layer.Type: GrantFiled: February 15, 2011Date of Patent: October 6, 2015Assignee: Lightship Medical LimitedInventors: Barry Colin Crane, William Paterson, Bruce Culbert
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Patent number: 9115063Abstract: The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety. There is further provided a method of sensing the presence of a target analyte using the fluorescent sensor compound, as well as the use of the fluorescent sensor compounds to sense a target analyte.Type: GrantFiled: April 8, 2010Date of Patent: August 25, 2015Assignee: Lightship Medical LimitedInventor: Timothy Charles Higgs
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Publication number: 20150219663Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through said barrier layer.Type: ApplicationFiled: January 26, 2015Publication date: August 6, 2015Applicant: LIGHTSHIP MEDICAL LIMITEDInventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
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Patent number: 9097687Abstract: A sensor kit comprising a sensor for detecting an analyte, a sensor housing and a calibration chamber. The calibration chamber comprises a first compartment containing a first calibration solution and a second compartment containing a source of the analyte to be detected. A dividing material is located between the first and second compartments enabling them to be mixed on breakage or removal of the dividing material. Further compartment(s) containing further source(s) of the analyte may optionally be provided. Calibration can carried out by (a) taking a reading of the analyte concentration of the first calibration solution, (b) mixing the contents of the first and second compartments by breaking or removing the dividing material, and (c) taking a reading of the analyte concentration of the resulting mixture. Steps (b) and (c) can be repeated for further compartment(s) to provide further reading(s) if desired.Type: GrantFiled: March 26, 2012Date of Patent: August 4, 2015Assignee: Lightship Medical LimitedInventors: Barry Crane, Ian Francis, Robert Perkins, William Paterson
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Patent number: 9017622Abstract: A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.Type: GrantFiled: November 27, 2012Date of Patent: April 28, 2015Assignee: Lightship Medical LimitedInventors: Barry Colin Crane, William Paterson, Nicholas Paul Barwell
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Publication number: 20140275909Abstract: The present disclosure provides a catheter comprising one or more infusion lumens each terminating at an infusion eye, and one or more sensor lumens each terminating at a sensor eye. The present disclosure also provides a sheath introducer comprising one or more sensor lumens each terminating at a sensor eye, and an introducer lumen terminating at an introducer eye.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Lightship Medical LimitedInventors: Mithun NARAYANAN, Robert PERKINS, Roger PAMMENT
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Publication number: 20140234982Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.Type: ApplicationFiled: October 8, 2013Publication date: August 21, 2014Applicant: Lightship Medical LimitedInventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
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Patent number: 8746031Abstract: A method of calibrating a glucose sensor, which method comprises: (a) preparing a first glucose-containing calibration solution by combining water or an aqueous solution with alpha and beta glucose, the alpha and beta glucose being provided in solid form; (b) exposing a glucose sensor to said first glucose-containing calibration solution and determining the sensor output; (c) exposing the glucose sensor to one or more further calibration solutions having different glucose concentrations from each other and from said first glucose-containing calibration solution and determining the sensor output for the or each calibration solution; and (d) determining a calibration curve from the sensor output data collected in steps (b) and (c).Type: GrantFiled: November 16, 2011Date of Patent: June 10, 2014Assignee: Lightship Medical LimitedInventors: Barry Colin Crane, William Paterson
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Publication number: 20130344619Abstract: A method of quantifying the amount of glucose in a sample is provided herein that may further comprise an interferent such as mannitol. At least two measurements are obtained using measurement methods that differ in their sensitivity to the amount of interferent in the sample, thus enabling the results to be compared to determine whether any interferent is present in the sample.Type: ApplicationFiled: November 27, 2012Publication date: December 26, 2013Applicant: LIGHTSHIP MEDICAL LIMITEDInventors: Barry Colin Crane, William Paterson, Nicholas Paul Barwell, Peter Edgley
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Patent number: 8607612Abstract: A method of calibrating a reversible-binding sensor for detecting an analyte includes: (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.Type: GrantFiled: November 27, 2012Date of Patent: December 17, 2013Assignee: Lightship Medical LimitedInventors: Nicholas Paul Barwell, Peter Edgley, Alasdair Allan Mackenzie, William Paterson, Barry Colin Crane
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Publication number: 20130266478Abstract: A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.Type: ApplicationFiled: November 27, 2012Publication date: October 10, 2013Applicant: LIGHTSHIP MEDICAL LIMITEDInventors: Barry Colin Crane, William Paterson, Nicholas Paul Barwell
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Publication number: 20130084649Abstract: A sensor for fluorescence measurement comprising: a light source arranged for emitting light to a sample region, wherein the light source intensity is modulatable; an indicator system located at the sample region, said indicator system comprising: a receptor for an analyte; and a fluorophore associated with said receptor, wherein the fluorophore has a fluorescence lifetime that changes in response to the presence of analyte at the receptor; a single photon avalanche diode arranged to receive fluorescence light emitted from said sample region in response to the light incident on the sample region from the light source, and to generate an output signal; a driver arranged to modulate the light source intensity at a first frequency; a bias voltage source arranged to apply a bias voltage to the single photon avalanche diode, wherein the bias voltage is modulated at a second frequency, different from the first frequency, and wherein the bias voltage is above the breakdown voltage of the single photon avalanche diodType: ApplicationFiled: February 15, 2011Publication date: April 4, 2013Applicant: LIGHTSHIP MEDICAL LIMITEDInventors: Barry Colin Crane, John Gilchrist, Neil Cairns
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Publication number: 20130083820Abstract: A method of calibrating a reversible-binding sensor for detecting an analyte includes: (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.Type: ApplicationFiled: November 27, 2012Publication date: April 4, 2013Applicant: Lightship Medical LimitedInventor: Lightship Medical Limited