Patents Assigned to Lilly ICOS LLC
  • Modified Pictet-Spengler reaction and products prepared therefrom
    Patent number: 7550479
    Abstract: A method of introducing a second stereogenic center into a tetrahydro-?-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: June 23, 2009
    Assignee: Lilly ICOS LLC
    Inventors: Mark W. Orme, Michael J. Martinelli, Christopher W. Doecke, Joseph M. Pawlak, Erik C. Chelius
  • Medicament for treatment of neuropathies
    Patent number: 7338955
    Abstract: Compounds of formula (I) in which R1=C1-6 alkyl, optionally halosubstituted; R2=H, C1-4 alkyl, optionally halosubstituted or replaced by halogen; R3=C2-4 alkyl, optionally halosubstituted; R4=SO2NR5R&, CO2R7 or halogen, C2-4 alkenyl; optionally substituted with NR5R6, SONR5R6, CONR5R6, CO2R7 or halogen, C2-4 alkanoyl, optionally substituted with NR5R6, SONR5R6, CONR5R6, CO2R7 or halogen; R5 and R6=independently H or C1-4 alkyl, or, together with the N atom to which they are attached, a pyrrolidino, piperidino, morpholino, 4-(NR8)-1-piperazinyl or 1-imidazolyl ring optionally substituted with one or two C1-4 alkyl groups; R7=H, C1-4 alkyl, optionally fluorosubstituted, and R8=H,C1-3 alkyl or hydroxyalkyl with 1-4 C atoms, or the pharmaceutically acceptable salts thereof are useful for the chemotherapeutic treatment of neuropathies.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: March 4, 2008
    Assignee: Lilly ICOS LLC
    Inventor: Juerg Lareida
  • Treatment of benign prostatic hypertrophy and lower urinary tract symptoms
    Publication number: 20070093493
    Abstract: A method of treating symptoms of benign prostatic hypertrophy and a method of treating lower urinary tract symptoms, are disclosed. The method includes administering to a mammal about 1 to about 20 milligrams of an agent that inhibits cyclic guanosine 3,5-monophosphate specific phosphodiesterase type 5.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 26, 2007
    Applicant: LILLY ICOS LLC
    Inventors: Bela Denes, Kenneth Ferguson, John Whitaker
  • ?-carboline pharmaceutical compositions
    Patent number: 7182958
    Abstract: Formulations containing a PDE5 inhibitor, a water-soluble diluent, a lubricant, a hydrophilic binder, a disintegrant, and optional microcrystalline cellulose and/or a wetting agent, and their use in treating sexual dysfunction, are disclosed.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: February 27, 2007
    Assignee: Lilly Icos LLC.
    Inventors: Peter L. Oren, Neil R. Anderson, Martha A. Kral
  • Carboline derivatives
    Patent number: 7122554
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: October 17, 2006
    Assignee: Lilly Icos LLC.
    Inventors: Jason S. Sawyer, Mark W. Orme, Raymond F. Brown, Alain C. Daugan, Agnes Bombrun
  • Chemical compounds
    Patent number: 7115621
    Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents as inhibitors of phosphodiesterase 5 cardiovascular disorders
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: October 3, 2006
    Assignee: Lilly Icos LLC
    Inventors: Jason S. Sawyer, Mark W. Orme, James D. Copp
  • Tetracyclic compounds as PDE5-inhibitors
    Patent number: 7105506
    Abstract: Compounds of structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: September 12, 2006
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Pyrazino [1'2':1,6 ] pyrido [3, 4-b] indole-1,4-dione derivatives
    Patent number: 7098209
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: August 29, 2006
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Fused heterocyclic derivatives as phosphodiesterase inhibitors
    Patent number: 7034027
    Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: April 25, 2006
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M. Schultze
  • Carboline derivatives
    Patent number: 7022856
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: April 4, 2006
    Assignee: LIlly Icos LLC.
    Inventors: Mark W. Orme, Jason S. Sawyer, Agnes Bombrun, Romain L. Gosmini, Anne Bouillot, Nerina Dodic, Michael Sierra
  • Carboline derivatives as PDE5 inhibitors
    Patent number: 6992192
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: January 31, 2006
    Assignee: Lilly Icos LLC.
    Inventors: Jason S. Sawyer, Mark W. Orme
  • Carboline derivatives as PDE5 inhibitors
    Patent number: 6984641
    Abstract: Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: January 10, 2006
    Assignee: Lilly Icos LLC.
    Inventors: Mark W. Orme, Jason S. Sawyer, Alain C. Daugan, Agnes Bombrun, Françoise Gellibert, Lisa M. Schultze, Raymond F. Brown, Romain L. Gosmini
  • Hexahydropyrazino[1'2';1,6]pyrido[3,4-b]indole-1,4-diones for the treatment of cardiovascular disorders and erectile dysfunction
    Patent number: 6962918
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: November 8, 2005
    Assignee: Lilly Icos LLC.
    Inventors: Mark W. Orme, Lisa M. Schultze, Jason Scott Sawyer, Alain Claude-Marie Daugan, Raymond Brown
  • Condensed pyrazindione derivatives as PDE inhibitors
    Patent number: 6960587
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: November 1, 2005
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Lisa M. Schultze, Jason Scott Sawyer
  • Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
    Patent number: 6943166
    Abstract: The present invention relates to highly selective phosphodieterase (PDE) enzyme inhibitors and to their use in pharmaceutical articles of manufacture. In particular, the present invention relates to potent inhibitors of cyclic guanosine 3?,5?-monophosphate specific phosphodiesterase type 5 (PDE5) that when incorporated into a pharmaceutical product at about 1 to about 20 mg unit dosage are useful for the treatment of sexual dysfunction.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: September 13, 2005
    Assignee: Lilly ICOS LLC.
    Inventors: William Ernest Pullman, John Steven Whitaker
  • Pyrazino[1?,2?:1,6]pyrido[3,4b]indole derivatives
    Patent number: 6911542
    Abstract: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: June 28, 2005
    Assignee: Lilly Icos LLC.
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M. Schultze, Alain Claude-Marie Daugan, Francoise Gellibert
  • Condensed pyrazindione derivatives
    Patent number: 6903099
    Abstract: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: June 7, 2005
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M. Schultze
  • Indole derivatives as PDE5-inhibitors
    Patent number: 6878711
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: April 12, 2005
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M. Schultze
  • Derivatives of 2,3,6,7,12,12a-hexahydropyrazino-[1?,2?:1,6]pyrido[3,4b]-indole-1,4-dione
    Patent number: 6872721
    Abstract: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: March 29, 2005
    Assignee: Lilly ICOS LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Alain Claude-Marie Daugan
  • Condensed pyridoindole derivatives
    Patent number: 6858620
    Abstract: Compounds of general structural formula (I), and use of the compounds or salts or solvates thereof as therapeutic agents, are disclosed
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: February 22, 2005
    Assignee: Lilly ICOS, LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Alain Claude-Marie Daugan, Romain Luc Marie Gosmini, Lisa M. Schultze