Abstract: A class of novel 2-oxazolyl ureas and carbamates having anti-allergic activity are described together with methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention.
Type:
Grant
Filed:
December 27, 1977
Date of Patent:
November 20, 1979
Assignee:
Lilly Industries Limited
Inventors:
William J. Ross, Alex Todd, John P. Verge
Abstract: There are described novel pesticidal formulations in concentrate form which are aqueous emulsions containing 10% to 75% by weight of an herbicidal 2,6-dinitroaniline derivative, such as trifluralin, up to 60% by weight of water-immiscible solvent, 0.5% to 10% by weight of an emulsifying agent and 15% to 70% by weight of an aqueous solution of an inorganic salt, such as sodium chloride. The concentration of the inorganic salt in the aqueous solution is at least 5% by weight. The aqueous solution may additionally contain urea. The novel formulations are readily dispersible in large volumes of water in preparation for spraying and present a reduced fire risk compared with conventional concentrated formulations of 2,6-dinitroaniline herbicides.
Abstract: Thieno[1,5]benzodiazepines having useful CNS activity containing the novel tricyclic ring system: ##STR1## the 10-position being substituted by an amino, preferably a piperazino, group.
Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucelus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
Type:
Grant
Filed:
October 11, 1977
Date of Patent:
September 4, 1979
Assignee:
Lilly Industries Limited
Inventors:
William J. Ross, John P. Verge, William R. N. Williamson
Abstract: Acylamino pyrazolyl compounds of the formula: ##STR1## wherein Ar represents an optionally substituted pyrazolyl group, the acylamino group --NR.sup.1 COR.sup.2 being attached to a carbon atom of the pyrazolyl ring, which have anti-allergic activity, methods of making the compounds and pharmaceutical formulations containing the compounds.
Type:
Grant
Filed:
June 1, 1976
Date of Patent:
August 28, 1979
Assignee:
Lilly Industries Limited
Inventors:
Roger G. Harrison, William B. Jamieson, William J. Ross, John C. Saunders
Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds having anti-allergy activity.
Type:
Grant
Filed:
June 13, 1977
Date of Patent:
July 31, 1979
Assignee:
Lilly Industries Limited
Inventors:
William J. Ross, John P. Verge, William R. N. Williamson
Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
Type:
Grant
Filed:
October 7, 1977
Date of Patent:
June 19, 1979
Assignee:
Lilly Industries Limited
Inventors:
William J. Ross, John P. Verge, William R. N. Williamson
Abstract: Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
Type:
Grant
Filed:
June 22, 1977
Date of Patent:
May 1, 1979
Assignee:
Lilly Industries Limited
Inventors:
William J. Ross, John P. Verge, William R. N. Williamson
Abstract: Propanoic acid derivatives of the formula: ##STR1## where R.sup.1 is a C.sub.1-8 alkyl group optionally substituted by hydroxyl or --COOH and R.sup.2 is hydrogen or a protecting group, are useful as anti-thrombotic agents.
Type:
Grant
Filed:
December 4, 1975
Date of Patent:
April 24, 1979
Assignee:
Lilly Industries Limited
Inventors:
William Dawson, Michael J. Foulis, Norman J. A. Gutteridge, Colin W. Smith
Abstract: Oxazoles which are substituted in the 2,4 or 5-position with an N-substituted-acylamino group have anti-allergic activity. Methods of making such compounds, pharmaceutical compositions containing the active compounds of the invention and methods of treating asthma utilizing such compounds are provided.
Abstract: A small tablet containing over 90% by weight of an orally active cephalosporin such as cephalexin and which utilizes as a binder polyvinyl pyrrolidone having a number average molecular weight of from 500,000 to 1,500,000.
Abstract: Oxazoles having a sulfinyl or sulfonyl substituent at the 2-position are provided. Such compounds readily react with an alkali metal salt of a secondary amide in a method of making 2-acylamino oxazole derivatives having anti-allergic activity.
Abstract: o-Hydroxybenzophenones and derivatives thereof are described together with a process for their production. The compounds have anti-allergy activity and are characterized by the presence of an alkyl substituent on the hydroxyphenyl ring.
Type:
Grant
Filed:
September 2, 1977
Date of Patent:
February 27, 1979
Assignee:
Lilly Industries Limited
Inventors:
John C. Saunders, William R. N. Williamson
Abstract: Novel heteroaryl ketone derivatives, specifically a class of phenyl heteroaryl methanone derivatives, having anti-allergy activity, pharmaceutical formulations containing diphenylmethane derivatives and methods of treatment utilizing such derivatives.
Type:
Grant
Filed:
October 11, 1977
Date of Patent:
December 26, 1978
Assignee:
Lilly Industries Limited
Inventors:
Delme Evans, John C. Saunders, William R. N. Williamson
Abstract: Phenylpiperazine derivatives of formula (I): ##STR1## where R.sup.1 is benzyl, C.sub.1-6 alkyl or optionally substituted phenyl; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; Q is furan, thiophene, oxazole or thiazole; m is 1 to 3 and n is 0 or 1; and pharmaceutically-acceptable salts thereof are active in the chemotherapy of immediate hypersensitivity conditions such as asthma.
Abstract: An aryl sulphur compound of formula (I) : ##STR1## where R.sup.1 is C.sub.1-4 alkyl; Ar is a phenyl group optionally substituted by halogen or C.sub.1-4 alkyl and wherein Z is S or SO, having antiallergy activity.
Type:
Grant
Filed:
September 30, 1977
Date of Patent:
October 24, 1978
Assignee:
Lilly Industries Limited
Inventors:
Delme Evans, John Christopher Saunders, William Robert Nigel Williamson
Abstract: A class novel 2,4 or 5-acylamino oxazoles having anti-allergic activity, methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention. The compounds of the invention have been shown to be useful in the prophylactic and therapeutic treatment of immediate hypersensitivity diseases including asthma and in the alleviation of status asthmaticus.
Abstract: Thieno[1,5]benzodiazepines having useful CNS activity containing the novel tricyclic ring system: ##STR1## the 10-position being substituted by an amino, preferably a piperazino, group.
Type:
Grant
Filed:
June 1, 1977
Date of Patent:
September 19, 1978
Assignee:
Lilly Industries Limited
Inventors:
Jiban Kumar Chakrabarti, David Edward Tupper
Abstract: Thieno[1,5]benzodiazepines having useful CNS activity containing the novel tricyclic ring system: ##STR1## the 10-position being substituted by an amino, preferably a piperazino, group.
Type:
Grant
Filed:
April 13, 1977
Date of Patent:
September 19, 1978
Assignee:
Lilly Industries Limited
Inventors:
Jiban Kumar Chakrabarti, David Edward Tupper
Abstract: 1,2,3-triazoles and 1,2,4-triazoles having an N-substituted acylamino substituent are prepared by alkylating N-unsubstituted acylamino triazoles or acylating N-substituted amino triazoles. The N-substituted acylamino triazoles are useful as anti-allergy drugs. Pharmaceutical formulations containing acylamino triazoles and a method of treating allergic conditions utilizing such compounds are provided.
Type:
Grant
Filed:
June 1, 1976
Date of Patent:
May 16, 1978
Assignee:
Lilly Industries Limited
Inventors:
Roger Garrick Harrison, William Boffey Jamieson, William James Ross, John Christopher Saunders