Patents Assigned to Lilly Industries, Ltd.
  • Organic derivatives
    Patent number: 4039571
    Abstract: Propanoic acid derivatives of formula: ##STR1## where X represents a ketonic or hydroxylic function, R.sup.1 is a C.sub.1.sub.-8 alkyl group optionally substituted by hydroxy or --COOH and R.sup.2 is hydrogen or a protecting group, having spasmolytic activity.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: August 2, 1977
    Assignee: Lilly Industries, Ltd.
    Inventors: William Dawson, Michael John Foulis, Norman James Albert Gutteridge, Colin William Smith
  • Thiazole derivatives
    Patent number: 4035390
    Abstract: 2-Nitroimidazolyl-4-thiomorpholinoiminoalkyl thiazoles are useful as anti-parasitic agents, being active against Trypanosomidae, and may be prepared by reaction of novel 2-nitroimidazolyl-4-acylthiazoles with an N-aminothiomorpholine.
    Type: Grant
    Filed: August 9, 1976
    Date of Patent: July 12, 1977
    Assignee: Lilly Industries, Ltd.
    Inventors: John Pomfret Verge, Martin Charles Neville
  • 3-Substituted propanoic acid derivatives and pharmaceutical composition
    Patent number: 4027036
    Abstract: The invention provides 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)-propanoic acid and derivatives thereof having anti-thrombotic activity coupled with low toxicity. Also provided is a method for preparing such compounds by subjecting a 3-[3-hydroxy-5-oxo-2-(.beta.-styryl)cyclopent-1-enyl]-propanoic acid or derivative thereof to oxidative cleavage.
    Type: Grant
    Filed: April 10, 1974
    Date of Patent: May 31, 1977
    Assignee: Lilly Industries, Ltd.
    Inventors: William Dawson, Michael John Foulis, Norman James Albert Gutteridge, Colin William Smith
  • 2,5 OR 2,6 Disubstituted benzoxazoles
    Patent number: 4025637
    Abstract: 5- or 6-Substituted benzoxazole propionic or acetic acid derivatives, substituted in the 2-position of the oxazole nucleus by a group of the formula AR.sup.4 wherein A is --CH.sub.2 --, --CO--, --CHOR--, or --NR--, wherein R is hydrogen, C.sub.1.sub.-6 alkyl or C.sub.2.sub.-7 acyl, and R.sup.4 is optionally substituted phenyl, useful as non-steroidal, non-narcotic, analgesic, antipyretic and anti-inflammatory agents.
    Type: Grant
    Filed: February 4, 1976
    Date of Patent: May 24, 1977
    Assignee: Lilly Industries, Ltd.
    Inventors: David William Dunwell, Delme Evans, Terence Alan Hicks
  • 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles
    Patent number: 4025636
    Abstract: 2-(Optionally substituted)phenyl-benzoxazoles having a carboxy alkyl, a tetrazolyl, or oxazolinyl group at the 5 or 6 position useful as aspirin-like non-steroidal, non-narcotic, analgesic, antipyretic and anti-inflammatory agents.
    Type: Grant
    Filed: February 4, 1976
    Date of Patent: May 24, 1977
    Assignee: Lilly Industries, Ltd.
    Inventors: David William Dunwell, Delme Evans, Terence Alan Hicks
  • Pharmacologically active propanoic acid derivatives
    Patent number: 4000189
    Abstract: The invention provides styryl cyclopentenyl propanoic acids and derivatives thereof having spasmolytic activity coupled with low toxicity. Also provided is a method of preparing styryl cyclopentenyl propanoic acid compounds which involves cyclising 7-hydroxy-5,8-dioxo-10-phenyldec-9-enoic acid in the presence of a base.
    Type: Grant
    Filed: April 10, 1974
    Date of Patent: December 28, 1976
    Assignee: Lilly Industries, Ltd.
    Inventors: William Dawson, Michael John Foulis, Norman James Albert Gutteridge, Colin William Smith
  • Thiazole derivatives
    Patent number: 3989690
    Abstract: 2-Nitroimidazolyl-4-thiomorpholinoiminoalkyl thiazoles are useful as anti-parasitic agents, being active against Trypanosomidae, and may be prepared by reaction of novel 2-nitroimidazolyl-4-acylthiazoles with an N-aminothiomorpholine.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: November 2, 1976
    Assignee: Lilly Industries, Ltd.
    Inventors: John Pomfret Verge, Martin Charles Neville
  • Secondary and tertiary-2-phenylbicyclo[2,2,2]oct-3-yl alkylamines and composition thereof
    Patent number: 3980785
    Abstract: Secondary and tertiary 2-phenylbicyclo[2,2,2]oct-3-yl alkyl amines are useful as anti-depressant and anti-Parkinsonism agents. They may be prepared from the corresponding aldehydes, nitriles, amides, isocyanates or esters using known chemical techniques.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: September 14, 1976
    Assignee: Lilly Industries, Ltd.
    Inventor: Eric Wildsmith
  • Preparation of .alpha.-acetoxy aldehydes and ketones
    Patent number: 3965157
    Abstract: An improved method for the preparation of intermediates of formula: ##EQU1## WHERE R.sup.1 and R.sup.2 represent hydrogen, C.sub.1.sub.-4 alkyl, C.sub.1.sub.-4 hydroxyalkyl, C.sub.3.sub.-10 cycloalkyl, C.sub.3.sub.-6 acyloxyalkyl, or phenyl, by mercuric ion assisted hydrolysis of the corresponding dithianes, and novel intermediates thereby produced.
    Type: Grant
    Filed: December 16, 1974
    Date of Patent: June 22, 1976
    Assignee: Lilly Industries, Ltd.
    Inventor: Roger Garrick Harrison
  • Benzoxazole derivatives in treating inflammation, pain and fever
    Patent number: 3962441
    Abstract: The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclising an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.
    Type: Grant
    Filed: June 17, 1975
    Date of Patent: June 8, 1976
    Assignee: Lilly Industries, Ltd.
    Inventors: Delme Evans, David William Dunwell, Terence Alan Hicks
  • Benzoxazole derivatives as therapeutics
    Patent number: 3962452
    Abstract: The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclising an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.
    Type: Grant
    Filed: June 17, 1975
    Date of Patent: June 8, 1976
    Assignee: Lilly Industries, Ltd.
    Inventors: Delme Evans, David William Dunwell, Terence Alan Hicks
  • Anti-inflammatory 1,2-benzisoxazole derivatives
    Patent number: 3951999
    Abstract: 3-Phenyl substituted 1,2-benzisoxazole acetic and propionic acid derivatives with anti-inflammatory activity.
    Type: Grant
    Filed: October 16, 1974
    Date of Patent: April 20, 1976
    Assignee: Lilly Industries, Ltd.
    Inventors: John Christopher Saunders, William Robert Nigel Williamson
  • Bottle
    Patent number: D249866
    Type: Grant
    Filed: June 21, 1976
    Date of Patent: October 10, 1978
    Assignee: Lilly Industries, Ltd.
    Inventor: Ieuan Richard Felix