Abstract: According to some aspects, there is provided a device configured to determine a measure of brain tissue motion in a brain, comprising: at least one transducer configured to transmit an acoustic signal to at least one region of the brain and receive a subsequent acoustic signal from the at least one region of the brain; and at least one processor configured to: determine the measure of brain tissue motion in the at least one region of the brain by processing the subsequent acoustic signal, wherein processing the subsequent acoustic signal comprises filtering the subsequent acoustic signal. Filtering the subsequent acoustic signal may comprise one of spatiotemporal filtering, signal decomposition, tissue tracking, and/or spectral clustering.

Abstract: Described herein are techniques for non-invasively measuring intracranial ICP in a subject's brain. Some embodiments use a physics guided machine learning model to determine measurements of various metrics (e.g., ICP, ABP, and/or ICE) of a subject's brain. The structure of the physics guided machine learning model may be based on a model of the brain (e.g., a hemodynamic or elastic model of the brain). The physics guided machine learning model may include various machine learning models (e.g., neural networks) representing different aspects of the brain's fluid dynamics and/or mechanics. The techniques may use acoustic measurement data (e.g., obtained using ultrasound) in conjunction with other information to generate inputs for the physics guided machine learning model. The inputs may be used to measurements of a metric for the subject's brain.

Abstract: In some aspects, a method includes forming a beam in a direction relative to a brain of a person, the direction being determined by a machine learning model trained on data from prior signals detected from a brain of one or more persons and, after forming the beam, detecting a signal from a region of interest of the brain of the person.

Abstract: In some aspects, the described systems and methods provide for a device wearable by or attached to a person, comprising at least one annular array transducer configured to provide ultrasound radiation to at least one region of the brain of the person. In some embodiments, the annular array transducer is configured to provide the ultrasound radiation to perform non-invasive neuromodulation or neurostimulation in the at least one region of the brain of the person.