Abstract: Methods and systems for motion-corrected and motion-compensated laser speckle contrast imaging are disclosed which comprise exposing a target area to coherent first light of a first wavelength, the target area including living tissue, and capturing at least one sequence of images comprising first speckle images and determining one or more transformation parameters of an image registration algorithm for registering the first speckle images with each other. The transformation parameters may be based on a similarity measure of pixel values of groups of pixels in a plurality of images of the at least one sequence of images the images in the plurality of images being selected from the first speckle images or being associated with the first speckle images.