Abstract: In some aspects, a device comprises a substrate and at least one CMUT located on or in the substrate that provides ultrasound radiation to a brain of a patient. In some aspects, a method of guiding ultrasound radiation in the brain of a patient comprises receiving as a first input patient scan data, receiving as a second input information regarding configuration and/or properties of ultrasound transmitters adapted to transmit to the brain the ultrasound radiation, processing at least one of the first and second inputs and feeding the processed at least one of the first and second inputs into a physical acoustics model, and based on an output of the physical acoustics model and acquired data from the brain of the patient, generating an instruction to transmit to the brain of the patient the ultrasound radiation.