Abstract: This invention relates to polynucleotides comprising optimized CLN5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLN5 gene or aberrant activity of a CLN5 gene product in the subject, such as CLN5 disease.

Abstract: A configuration and method for straightening a wire as the wire pays off from a bulk package. A bulk package hat is configured to be positioned over an opened bulk package containing wire bent in a helix shape. A bearing assembly is mounted inside the bulk package hat at a position where the wire exits the bulk package hat as the wire pays off from the bulk package. A wire straightening device has a plurality of rollers and only one single plane of straightening, and is configured to apply a counter bend to the wire as the wire pays off from the bulk package through the wire straightening device. The wire straightening device is operatively connected to the bearing assembly at an angle inside the bulk package hat. The bearing assembly and the single plane of straightening rotate, continually realigning with a current direction of the wire as it pays off.

Abstract: A method of correcting angles of a welding torch positioned by a user while training a robot of a robotic welding system is provided. Weldment depth data of a weldment and a corresponding weld seam is acquired and 3D point cloud data is generated. 3D plane and intersection data is generated from the 3D point cloud data, representing the weldment and weld seam. User-placed 3D torch position and orientation data for a recorded weld point along the weld seam is imported. A torch push angle and a torch work angle are calculated for the recorded weld point, with respect to the weldment and weld seam, based on the user-placed torch position and orientation data and the 3D plane and intersection data. The torch push angle and the torch work angle are corrected for the recorded weld point based on pre-stored ideal angles for the weld seam.

Abstract: The use of ferric sulphate or polyferric sulphate to treat liquid animal effluent to reduce methane emissions therefrom.

Abstract: A system and method for submerged arc welding. The system advances a consumable welding electrode toward a workpiece, and then stops the advancement when the consumable electrode makes contact with the workpiece. The system provides a preheating current level through the consumable welding electrode proximate the workpiece while the consumable welding electrode is in contact with the workpiece during a preheating period of time to preheat the portion of the consumable welding electrode without establishing an arc. The system then retracts the consumable welding electrode from the workpiece and increases the preheating current level to a welding current level over an arc establishment period of time to establish an arc between the consumable welding electrode and the workpiece. The system then begins to form a weld by advancing the consumable welding electrode toward the workpiece again, resulting in melting the consumable welding electrode and depositing molten metal onto the workpiece.

Abstract: A system and method generates a short circuit arc welding waveform output, having a pinch phase with a break point and a necking threshold, between a welding electrode and a work piece during a short circuit arc welding process. A necking threshold energy and a break point energy of the short circuit arc welding waveform output are monitored during the short circuit arc welding process, and a running average of the necking threshold energy is generated. An actual pinch energy relationship value is calculated based on the running average of the necking threshold energy and the break point energy, and is compared to a previously specified pinch energy relationship value. The break point energy of the short circuit arc welding waveform output is adjusted in response to the comparison to maintain the actual pinch energy relationship value to be at the specified pinch energy relationship value.

Abstract: A regulating valve device for a fluid cylinder includes a shut off valve having a ball tappet that actuates the shut off valve. A lever has a cam surface that interacts with the ball tappet as the lever is rotated to translate the ball tappet linearly and actuate the shut off valve. The lever is rotatable from a first valve closed position through a valve open position to a second valve closed position such that the valve open position is intermediate of the first and second valve closed positions. A pressure or flow regulating valve is downstream of the shut off valve. A handwheel is operatively connected to the pressure or flow regulating valve to adjust an outlet pressure of the pressure or flow regulating valve. The handwheel has an axis of operation that is offset from a longitudinal axis of the fluid cylinder by an acute angle.

Abstract: A system for maintaining the operating condition of a machine is provided. The system includes a dispensing device having: an interchangeable control module, the interchangeable control module including control hardware that provides a central processing unit, a data storage memory, and communication modules. The dispensing device is configured to dispense lubricant in order to maintain the operating condition of the machine. The interchangeable control module is configured to interchangeably control and interchangeably reside in either a fixed or a portable dispensing device. The interchangeable control module communicates to an external or internal intermediary computing device.