Abstract: The present invention provides a method for the quantification and assessment of platelet activation in whole blood samples and monitoring of antiplatelet pharmacologic agents. The method for quantifying platelet activation includes exposing platelets to a physiological concentration of an agonist that activates some of the platelets, resulting in the formation of at least one binding site on the surface of the activated platelets, and measuring the activated platelets. The present invention provides a method of assessing specific components of platelet activation.

Abstract: A problem in pulse oximetry is discriminating between arterial and non-arterial oxygen. Non-arterial oxygen can become detectable by an oximeter when a patient moves, obscuring the oximeter's measurement of arterial oxygen at critical times. Recent advances in pulse oximetry have made it possible to make the discrimination between arterial and non-arterial blood oxygen values. To allow manufacturers, hospitals, and medical researchers to evaluate the new oximetry technology, and evaluate oximeters which use it, new simulation technology is presented which can simulate simultaneous arterial and non-arterial blood oxygen on demand, with precision as to oxygen value, waveform amplitude, and waveform frequency. This invention provides the required simulation by double amplitude modulating the red and infra-red oximeter pulses.