Abstract: A method, system, and computer product for determining intracranial pressure (ICP) of a subject non-invasively. The method including: applying at least one selected controlled force to an eye of the subject; imaging retinal vascular pulsation of the eye of the subject over at least one cardiac cycle at the at least one selected controlled force; processing the retinal vascular pulsation images to produce retinal vascular pulsation amplitude data as a time-varying signal; decomposing the time-varying signal into at least two frequency components representing the time-varying signal; determining intracranial pressure from a data basis which includes at least information associated with the frequency components, and wherein the retinal vascular pulsation data includes at least retinal arterial pulsation data.

Abstract: This invention relates generally to the inhibition of cytomegalovirus (CMV) reactivation in immunosuppressed subjects, including subjects receiving hematopoietic or solid organ transplants. The present invention is particularly relevant for the treatment of CMV reactivation or infection in subjects with graft-versus-hosts disease (GVHD) or under immunosuppressive therapy.

Abstract: Ophthalmic tissue delivery devices that include an injector and injector carriers and methods for endothelial keratoplasty surgical procedures are provided. Injectors include a conduit sized to accommodate ophthalmic tissue. One end of the injector is configured for insertion into a patient's eye to inject ophthalmic tissue. Injector carriers include a container, a cap configured to seal an opening of the container. The injector can be coupled to a pressure actuated valve and a syringe where activating the syringe opens the value and allows fluid to flow from the syringe, through the valve, and through the injector to dispense ophthalmic tissue from the injector into a patient's eye without the need to physically contact the ophthalmic tissue.

Abstract: A method and apparatus for determining intracranial pressure includes a contact lens; a camera for making a plurality of images of at least one eye of a subject; one or more force transducers for controllably applying a force to the eye via the contact lens; a support system for supporting the camera, the contact lens and the one or more force transducers against the eye; and a computing device for controlling the force applied to the eye by the force transducers and stabilizing the force by negative feedback.

Abstract: A method and apparatus for determining intracranial pressure, includes a contact lens; a camera for making a plurality of images of at least one eye of a subject; one or more force transducers for controllably applying a force to the eye via the contact lens; a support system for supporting the camera, the contact lens and the one or more force transducers against the eye; and a computing device for controlling the force applied to the eye by the force transducers and stabilizing the force by negative feedback.

Abstract: An apparatus for irradiating a specimen: that includes an optical transmitter for transmitting light from a laser source; an optical probe configured to receive the light from the optical transmitter and to apply the light upon emission from an optical exit to the specimen; a position detector adapted to detect a position of the optical probe in a longitudinal direction and to output a signal indicative of the position or of a change in the position relative to a surface forward of the optical probe; a drive coupled to the optical probe and adapted to controllably adjust a position of the optical probe in the longitudinal direction; and a feedback controller adapted to receive the signal from the position detector and to control the drive to control the position to keep the optical probe at substantially a constant position relative to the surface forward of the optical probe.

Abstract: The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by administering subretinally a pharmaceutical composition comprising a pharmaceutically effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase-1 (sFlt-1) protein to the human subject.

Abstract: An ophthalmic camera (10) comprising a camera (12) having a lens (18) aligned with a second lens (16) and at least one illumination means (14). The illumination means (14) is capable of movement relative to the camera lens (18) so that the beam of light emitted by the illumination means (14) is able to be focused by the second lens (16) through the pupil onto the fundus. In another embodiment, the ophthalmic camera comprises a camera (52), an illumination means (54) and a beamsplitter (58). The camera (52) and the beamsplitter (58) from an alignment axis X and the illumination means (54) together with the beam splitter (58) form an illumination axis Y perpendicular to the alignment axis X.

Abstract: Provided is a multi-purpose imaging apparatus (10) comprising a body (14) and imaging means (36) housed within the body (14). The body (14) is adapted to releasably engage an adaptor (12). The adaptor (12) has an aperture (108) extending therethrough that aligns with the optical axis (X) of the imaging means (36) when so engaged, such that at least a portion of the optical axis (X) is not obscured. The adaptor (12) also has optics for illuminating a subject within the optical axis (X) for diagnostic purposes.

Abstract: Provided is an ophthalmic camera comprising: a camera having a camera lens; at least one illumination means; and an ophthalmic lens. The centres of the ophthalmic lens and camera lens are aligned to form an alignment axis. The at least one illumination means is capable of linear movement along a radial axis of the camera lens and pivotal movement about the radial plane incorporating radial axis and alignment axis. In such a manner, the circle of light emitted by the at least one illumination means is constantly directed to the centre of the ophthalmic lens.

Abstract: This present invention discloses nucleic acid compositions and methods that are useful for treating ischemic conditions in animals, particularly in mammals such as humans. Specifically, the invention discloses nucleic acid molecules comprising or encoding a sequence that modulates the stability of a transcript from a vascular endothelial growth factor gene, as well as pharmaceutical compositions containing such molecules, which arm useful for modulating angiogenesis or vascularization, especially in methods for treating ischemic conditions.

Abstract: A portable slit-lamp apparatus, including a body (11) able to be held in the hand of an operator and a solid state lamp means (55) and associated optics (52) carried by the body for generating a narrow beam of light and projecting the beam onto the cornea of a patient s eye for reflection by structures of the eye, when the body is held at a suitable position in front of the eye. Means (22) is mounted in cooperation with the body and the solid state lamp means to detect a reflection of the narrow beam of light by structures of the eye and to make an image thereof, which image is, or is processable to provide, a digital record of the reflection.

Abstract: An apparatus and method for producing a high contrast, real time, three dimensional representation of a scanned object with the use of an additional scanning mechanism to gain information about the third dimension. A light beam is reflected along an input path and is modified, split, scanned in a first direction, scanned in a second direction, and directed through a stereo base producer to provide stereoscopic information by impinging the beam onto the surface from two different directions. It is then reflected onto the surface whereby the light traverses an output path identical to the input path towards a splitter. Some of the reflected light is directed towards a photodetector coupled to a signal processor to produce an image for real time viewing.

Abstract: The present invention provides a method for scanning material with a laser beam including directing a laser beam (20) through a scanning means, wherein said scanning means includes a first lens (11) and a second lens (12) separated by a distance (16) approximately equal to the focal length of the lenses. The method includes controlling the beam (20) by moving at least one of the lenses in a plane perpendicular to the beam to scan the material. The invention also provides a scanning apparatus for scanning material with a laser beam including laser means for producing a beam of ultraviolet or infra-red light, scanning means for scanning the laser source in a predetermined pattern onto an area of the material, and controlling means for controlling the scanning means, wherein the scanning means includes two lenses, separated by approximately the focal length of one of the lenses, with at least one of the lenses movable perpendicular to the beam to scan the beam.

Abstract: The present invention provides a microfistula tube including a soluble duct, defining a drainage canal having an inner surface, the duct being biocompatible, wherein the microfistula tube is coated with and/or incorporates biological for forming a basement membrane, or an intracellular matrix and a basement membrane. The biological cells may coat the inner surface of the drainage canal, and the microfistula tube may be made of a mouldable material or an absorbable material. The invention also provides an implantation system for the microfistula tube including a microfistula tube and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein the outer tube, the inner tube and the innermost rod are coaxial, the outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube.

Abstract: Disclosed is a method of insertion of keratoprostheses, and in particular, a method of surgical insertion and placement of a soft hydrogel prosthetic corneal device into the host cornea. The method of the invention provides a greatly improved rate of success for the implantation and retention of the device.

Abstract: The present invention provides an apparatus for producing an image of a surface, including a laser source for producing a beam of light, beam modifying means for modifying the properties of the beam, beam splitting means for splitting the beam, focusing means for focusing the beam, first and second scanning means for scanning the beam in first and second different directions, stereo base producing means for obtaining stereoscopic information concerning the surface by impinging the beam onto the surface from two different positions, and reflecting means, wherein a beam from the laser source may be directing along an input path including being modified with the modifying means and split by the beam splitting means, directed onto the first scanning means to scan the beam in the first direction, directed through the second scanning means to scan the beam in the second direction, directed through the stereo base producing means, and then directed off the reflecting means and onto the surface, whereby reflected lig

Abstract: A method and apparatus is provided for generating a laser beam of a wavelength suitable for ablating material. The apparatus includes a source of a laser beam of a wavelength which is not suitable for ablation and a frequency converter which uses harmonic generation to generate a laser beam of a suitable frequency. In preferred arrangements the frequency converter is a non-linear optical material that is maintained at a predetermined elevated temperature. In a preferred arrangement the pulse rate of the laser is selected to maintain the acceptance angle of the harmonic generator within predetermined limits.

Abstract: The invention provides an ocular socket prosthesis comprising a hydrogel consisting essentially of a biocompatible hydrophilic polymer onto which tissues can be directly sutured. Preferably the prosthesis comprises the polymer both in its homogeneous gel form and in its sponge form, and the two forms are chemically joined at their interface via an interpenetrating polymer network (IPN). However, it is also contemplated that the prosthesis of the invention may be made predominantly or entirely from the sponge form of the polymer. Methods of production of the prosthesis of the invention and of surgical implantation are also disclosed and claimed.

Abstract: The present invention provides a system for creating and visualising three-dimensional images of an object, including imaging means for obtaining two images of the same object from different angles, digitizing means for digitizing the images, image processing means for color matching and registering the images, controller means for converting the two images into an interlaced image, display means for displaying the registered interlaced image, and visualizing means for visualizing the image in three dimensions. It also provides a method for creating and visualising three-dimensional images of an object including obtaining two images of the same object from different angles, digitizing the images, color matching and registering the images, converting the two images into an interlaced image, displaying the registered interlaced image for visualizing the image in three dimensions, measuring areas of interest, and calculating desired measurements of the object.