Patents Assigned to LIPHA
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Computational data processing system and computational process implemented by means of such a system
Patent number: 7159012Abstract: This computational data processing system comprises an assembly of networked computers (12, . . . 22) in each of which is stored at least one computational application, and a machine (10) for storing computational data which is linked to the network and in communication with the computers, at least one of the computers (12) operating as master computer and at least some of the other computers (14, . . . 22) operating as slave computer. At least one of the computers comprises, stored in memory an algorithm for configuring the other computers of the network as slave computers and an executable master application for managing the tasks of each slave computer (14, . . . 22) as a function of their availability for the assignment, to each of them, of computational tasks and of corresponding computational data which are stored in the storage machine (10).Type: GrantFiled: March 15, 2001Date of Patent: January 2, 2007Assignee: LIPHAInventors: Edouard Viollet, Thierry Convard, Jacques Barbanton -
Patent number: 7034021Abstract: The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. Said compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome.Type: GrantFiled: January 25, 2001Date of Patent: April 25, 2006Assignee: LIPHAInventors: GĂ©rard Moinet, Daniel Cravo, Liliane Doare, Micheline Kergoat, Didier Mesangeau
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Publication number: 20050165022Abstract: The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1. The compounds are useful in the treatment of pathologies related to the insulin-resistance syndrome.Type: ApplicationFiled: March 22, 2005Publication date: July 28, 2005Applicant: LIPHAInventors: Gerard Moinet, Daniel Cravo, Liliane Doare, Micheline Kergoat, Didier Mesangeau
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Patent number: 6512009Abstract: A pharmaceutical composition for the treatment of alcohol and drug dependence, comprising a therapeutically effective amount of a combination of: (i) an opioid antagonist; and (ii) a NMDA receptor complex modulator. A pharmaceutical kit is also provided, comprising these two substances. The opioid antagonist can, for example, be naltrexone and the NMDA receptor complex modulator can be a spermidine site modulator such as acamprosate.Type: GrantFiled: January 12, 2001Date of Patent: January 28, 2003Assignee: LiphaInventors: Martine Daoust, Yves Bonhomme, Philippe Durbin
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Patent number: 6303146Abstract: The present invention relates to a solid oral dosage form comprising a combination of metformin and glibenclamide in which the size of glibenclamide is such that the glibenclamide bioavailability is comparable to the glibenclamide bioavailability obtained with a separate administration of metformin and glibenclamide.Type: GrantFiled: July 14, 1999Date of Patent: October 16, 2001Assignee: LIPHAInventors: Yves Bonhomme, Geoffrey Nicholson, Gillian Cave, Sarah J. Nicholson
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Computational data processing system and computational process implemented by means of such a system
Publication number: 20010023434Abstract: This computational data processing system comprises an assembly of networked computers (12, . . . 22) in each of which is stored at least one computational application, and a machine (10) for storing computational data which is linked to the network and in communication with the computers, at least one of the computers (12) operating as master computer and at least some of the other computers (14, . . . 22) operating as slave computer. At least one of the computers comprises, stored in memory an algorithm for configuring the other computers of the network as slave computers and an executable master application for managing the tasks of each slave computer (14, . . . 22) as a function of their availability for the assignment, to each of them, of computational tasks and of corresponding computational data which are stored in the storage machine (10).Type: ApplicationFiled: March 15, 2001Publication date: September 20, 2001Applicant: LiphaInventors: Edouard Viollet, Thierry Convard, Jacques Barbanton -
Patent number: 6265437Abstract: Derivatives of sulphonic aminoalkane acids, corresponding to formula (I) where X is R1, R2 and R3 are selected from hydrogen and a C1-C7 alkyl radical, and A is a group of the formula (e) where v and w are 0, 1, 2 or a group of formula (f) where R5 and R6 are selected independently of each other from hydrogen, a C1-C7 alkyl radical, an aryl radical having between 6 and 14 carbon atoms and a heteroaryl radical; t is 1-3; R4 is selected from hydrogen, a C1-C7 alkyl radical, a CF3 radical, an aryl radical having between 6 and 14 carbon atoms and a heteroaryl radical; M is a monovalent metal (Na, K, Li) or a divalent metal (Ca, Mg, Sr, Zn); m is 1 or 2; p is 1-2 and q is 1-2; and where p and q are such that the electrical neutrality of the salt is ensured. The compounds can be used for the treatment of alcohol dependence.Type: GrantFiled: October 12, 2000Date of Patent: July 24, 2001Assignee: LIPHAInventors: Jean-Jacques Berthelon, Philippe Durbin
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Patent number: 6226962Abstract: A method of producing a container (201, 231, 350) having a plurality of apertures (eg 202, 232, 352) each containing a respective dose of powdered material, such as a medicament, involves placing an empty container in a position in which its apertures communicate with a reservoir (216, 84) of powdered material. The material is then passed, for example by the flow of gas, from the reservoir into the apertures to fill the latter, and the container is then separated from the reservoir and the apertures are optionally sealed with sheet material (204, 206, 321, 323). Since the apertures are filled, their volume determines the amount of each dose which therefore does not have to be measured prior to introduction into the apertures. The container may comprise a rigid or flexible plate and in latter case can be subsequently rolled into the form of a cylinder for use in an inhaler. Apparatus for performing the method, and an inhaler for use with a cylindrical container, are also shown.Type: GrantFiled: May 17, 1995Date of Patent: May 8, 2001Assignee: Lipha SAInventors: Stephen William Eason, Clive Patrick Ashley Catterall, David Peter Griffin
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Patent number: 5617971Abstract: A device for dispensing single doses of powdered medicament has a housing for holding a container which has a number of sealed apertures containing individual encapsulating doses of medicament. The container can move relative to the housing to allow each aperture in succession to be brought into registry with an airway which communicates with a mouthpiece. The device includes a piercing member, such as a pin, which can be inserted into a selected aperture to break its respective seals. The configuration and movement of the pin are such that this action expels substantially no powder from the aperture.Type: GrantFiled: May 17, 1995Date of Patent: April 8, 1997Assignee: Lipha SAInventors: Stephen W. Eason, Clive P. A. Catterall, Roger W. Clarke
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Patent number: 5489592Abstract: Novel 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetic acids and derivatives of formula (I) ##STR1## in which R.sub.1 R.sub.2 and R.sub.3 are the same or different and stand for H, a halogen or a linear or branched aliphatic, saturated or unsaturated radical, substituted or not by at least one halogen or R.sub.4 residue such as defined below, except when R.sub.4 is H; R.sub.4 and R.sub.5 are the same or different and stand for H, a linear or branched aliphatic radical, saturated or unsaturated, an aryl or heteroaryl radical, said radicals being substituted or not by at least one grouping such as fluorine, chlorine, bromine, methyl or trifluoromethyl, where R.sub.4 and R.sub.5 do not simultaneously denote H; R.sub.6 stands for hydroxy or alkoxy radical; R.sub.Type: GrantFiled: June 20, 1994Date of Patent: February 6, 1996Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Francois Collonges, Herve Dumas, Philippe Durbin, Daniel Guerrier
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Patent number: 5476846Abstract: The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts, complexes, esters and amides thereof, represented by the formula ##STR1## which is defined herein. Said compounds find application as anti-thrombotic and anti-asthmatic medicines.Type: GrantFiled: November 17, 1994Date of Patent: December 19, 1995Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Claude Lardy, Daniel Guerrier, Gilles Chavernac, Francois Collonges
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Patent number: 5387709Abstract: The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts possibly in the form of complexes, esters and amides thereof, represented by the formula: ##STR1##Type: GrantFiled: October 12, 1993Date of Patent: February 7, 1995Assignee: Lipha Lyonnaise Industrielle PharmaceutiqueInventors: Claude Lardy, Daniel Guerrier, Gilles Chavernac, Francois Collonges
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Patent number: 5366532Abstract: Fertilizer containing microorganisms of the rhizosphere packaged by microencapsulation in a polysaccharide matrix. The inoculum obtained after microencapsulation can be mixed with a granular solid fertilizer, then stored, or with a liquid fertilizer immediately before spreading.Type: GrantFiled: October 27, 1989Date of Patent: November 22, 1994Assignee: Lipha, Lyonnaise IndustrielleInventors: Jacques Fages, Jacques Rigal, Daniel Mulard
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Patent number: 5338849Abstract: These compounds correspond to the formula ##STR1## in which one of the groups X.sub.1 to X.sub.4 represents nitrogen and the others a CH radical,R.sub.1 and R.sub.2 represent H, halogen, alkyl, hydroxymethyl, alkyloxymethyl, dialkylaminoalkyl, dialkylaminoalkyloxymethyl, carboxyl, ethyl carboxylate, piperidino, alkenyl, cycloalkyl, cycloalkenyl, alkylthio, benzyl, phenyl, thiophene or pyridine, optionally substituted,R.sub.3 and R.sub.4 represent H, halogen, alkyl, cycloalkyl, alkoxy or alkylthio,R.sub.5 and R.sub.6 denote H, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl or alkylthioalkyl, or together form alkylene or alkyleneoxyalkylene chains,R.sub.7 denotes H, alkyl or cycloalkyl; one of the radicals R.sub.5 to R.sub.7 can also denote optionally substituted phenyl or benzyl,R.sub.8 represents H, alkyl, cycloalkyl or optionally substituted phenyl or benzyl,R.sub.Type: GrantFiled: February 4, 1993Date of Patent: August 16, 1994Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Didier Festal, Denis Descours, Jacques Decerprit
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Patent number: 5272832Abstract: A bait station of the invention includes a container having an opening permitting a target pest to enter and exit, an internal chamber for storing a bait together with a pesticide, a lid which can be opened to permit direct access to the internal chamber, and three manually-releasable locking mechanisms capable of securing the lid to the container. The locking mechanisms are simultaneously actuated in order to release the lid from the container, and are spaced from each other by a distance sufficient to prevent a child from opening two of the locking mechanisms with one hand and the third with the other hand, but close enough to permit an adult to do so. The user must touch all three mechanisms and lift the lid at the same time to open the lid.Type: GrantFiled: August 3, 1992Date of Patent: December 28, 1993Assignee: Lipha, S.A.Inventors: Edward F. Marshall, Melanie S. Orth, Harry B. Lansing
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Patent number: 5270465Abstract: The present invention relates to 4(3H)-pteridinones represented by the formula: ##STR1## in which X is an oxygen atom or a sulphur atom, Y is a hydrogen atom, a lower alkyl radical, especially a methyl radical, at the 6-position or a hydroxyl group at the 7-position, R.sub.1 is a hydrogen atom, a lower alkyl radical, a substituted or unsubstituted phenyl radical, a benzyl radical, a methoxymethyl group, an acetyl group, a 2-acetoxyethyl group or a 2,2,2-trifluoroethyl group and R.sub.2 is a hydrogen atom or a lower alkyl radical, especially a methyl radical.Application of these compounds as anti-allergic drugs.Type: GrantFiled: November 3, 1992Date of Patent: December 14, 1993Assignee: Lipha, Lyonnaise Industrille PharmaceutiqueInventors: Gerard Ferrand, Herve Dumas, Jean-Claude Depin, Yvette Quentin
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Patent number: 5219859Abstract: The invention relates to indole derivatives of formula 1, ##STR1## in which: R.sub.1 and R.sub.2 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl, pyridylmethyl or phenyl, optionally substituted,R.sub.3 and R.sub.4 represent H, halogen, alkyl, alkoxy, alkylthio, CF.sub.3, NO.sub.2, N-alkylamino or N,N-dialkylamino, benzyl or phenyl, optionally substituted,R.sub.5 represents H, alkyl, cycloalkyl or optionally substituted benzyl,R.sub.6 denotes an alkyl, phenyl or heterocyclic radical, optionally substituted,Z denotes the bivalent radicals --(CH.sub.2).sub.n --C(R.sub.7 R.sub.8)--(CH.sub.2).sub.p --, --CH=CH--C(R.sub.7 R.sub.8)-- in which n=0--2, p=0--2 and n+p.ltoreq.2, R.sub.7 and R.sub.Type: GrantFiled: March 20, 1992Date of Patent: June 15, 1993Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Didier Festal, Denis Descours, Robert Bellemin, Jacques Decerprit
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Patent number: 5183924Abstract: Derivatives of benzocycloalkenyldihydroxyalkanoic acids, inhibitors of HMG CoA reductase, antagonists of thromboxane A.sub.2 receptors and antifungals, denoted by the formula I ##STR1## in which X=CH.sub.2, O or S; R.sub.1 and R.sub.2, identical or different, =H, C.sub.1-3 alkyl or together form a --(CH.sub.2).sub.n -- chain (n=4,5) optionally substituted symmetrically by one or two C.sub.1-3 alkyl radicals.R.sub.3 and R.sub.4, identical or different, =H, CF.sub.3, halogen (Cl, F, Br), C.sub.1-5 N,N-dialkylamino, C.sub.1-4 alkyl, C.sub.1-5 -alkoxy, C.sub.1-3 alkylthio, or phenyl optionally substituted by at most substituents which may be identical or different and may denote C.sub.1-3 alkyl or C.sub.1-3 alkoxy radicals or halogens (F, Cl), it being understood that when one of R.sub.3 and R.sub.4 denotes the radicals: CF.sub.3, N,N-dialkylamino, C.sub.6 H.sub.5 or substituted phenyl, it is present at the vertices 3', R' or 5' according to formula 1 and the other denotes a hydrogen atom.R.sub.5 and R.sub.Type: GrantFiled: October 24, 1991Date of Patent: February 2, 1993Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Didier Festal, Jean-Yves Nioche, Denis Descours, Robert Bellemin, Jacques Decerprit
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Patent number: 5167949Abstract: The present invention relates to 4(3H)-pteridinones represented by the formula: ##STR1## in which X is an oxygen atom or a sulphur atom, Y is a hydrogen atom, a lower alkyl radical, especially a methyl radical, at the 6-position or a hydroxyl group at the 7-position, R.sub.1 is a hydrogen atom, a lower alkyl radical, a substituted or unsubstituted phenyl radical, a benzyl radical, a methoxymethyl group, an acetyl group, a 2-acetoxyethyl group or a 2,2,2-trifluoroethyl group and R.sub.2 is a hydrogen atom or a lower alkyl radical, especially a methyl radical. Application of these compounds as anti-allergic drugs.Type: GrantFiled: March 29, 1990Date of Patent: December 1, 1992Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Gerard Ferrand, Herve Dumas, Jean-Claude Depin, Yvette Quentin
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Patent number: 5116954Abstract: Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S.fwdarw.(O).sub.n (n=0 or 2);R.sub.1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine, fluorine, diethylaminoethoxy, phenoxy, 2-methyl-4-thiazolyl, 2-amino-4-thiazolyl, phenyl, amino, nitro, terbutyl, carboxymethyl, acetamido, dimethyltriazenyl, benzoyl, hexyl, undecyl, trifluoromethyl, carbamoyl; or R.sub.1 is trifluoromethyl, pyridyl-2,pyridyl-4;R.sub.2 is H, methoxy, hydroxy; orR.sub.1 and R.sub.2 are --CH.dbd.CH--CH.dbd.CH--;R.sub.3 and R.sub.4 are methoxy, hydroxy, fluorine or form a fused benzene ring;CR.sub.5 R.sub.6 R.sub.7 is carboxymethyl, --CH.sub.2 --PO.sub.3 H,--CH.sub.2 --PO(oET).sub.2, 4-methylpiperazinyl, aminomethyl,3-4-5-trimethoxyphenylaminomethyl, acetyl, bromoacetyl, hydroxyethyl, acetoxyethyl, mercaptomethyl, acetylthiomethyl, methoxy-carbopnylthiomethyl, --CH--CONH.sub.2, ##STR2## substituted thiazolyl, subsituted furanone, imidazo(1,2-a)pyridinyl, indolizinyl, or R.sub.4 and R.Type: GrantFiled: August 2, 1989Date of Patent: May 26, 1992Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Philippe Briet, Jean-Jacques Berthelon, Francois Collonges