Patents Assigned to Lipocalyx GmbH
  • CARBOXYLATED POLYAMINE DERIVATIVES AS TRANSFECTION REAGENTS
    Publication number: 20150275220
    Abstract: The invention provides polyamine derivatives, a use of the polyamine derivatives for the transfection of polyanions into cells, and a method of transfecting cells with a polyanion, comprising mixing said polyanion with a polyamine derivative e.g. in a buffer and treating said cells with the mixture obtained in the previous step.
    Type: Application
    Filed: October 2, 2013
    Publication date: October 1, 2015
    Applicant: Lipocalyx GmbH
    Inventors: Steffen Panzner, Christian Reinsch, Volkmar Wendisch, Christina Dreher
  • CONSTRUCTION AND USE OF TRANSFECTION ENHANCER ELEMENTS
    Publication number: 20130011916
    Abstract: Nucleic acids comprising a nucleic acid moiety and two or more transfection enhancer elements (TEE's) according to the general formula (I): Hydrophobic moiety—pH-responsive hydrophilic moiety, wherein said pH sensitive hydrophilic moiety of said TEE is independently a weak acid having a pka of between 4 and 6.5 or is a zwitterionic structure comprising a combination of acidic groups with weak basis having a pKa of between 4.5 and 7.
    Type: Application
    Filed: April 30, 2012
    Publication date: January 10, 2013
    Applicant: Lipocalyx GmbH
    Inventor: Steffen Panzner