Abstract: The invention concerns liposome vectors, in powder form, of active principles, and more particularly active principles sensitive to digestive and/or plasmatic degradation, such as proteins, and their application as medicine. Said liposome vectors of active principles consist of a powder composition essentially constituted of unilamellar liposomes comprising an external lipid phase consisting of class 4 lipids (phospholipids), optionally associated with class 2 substances, class 3 substances and/or class 5 substances and an internal aqueous nucleus consisting of a mixture M of at least two different non-polymerisable gelling agents (G1 and G2) whereof the gel-sol phase transition is not less than 37° C.
Abstract: The invention concerns powder compositions of stabilised unilamellar liposomes, comprising at least an external lipid phase and a internal aqueous polar nucleus gelled at room temperature, the method for preparing them and their applications as nutritional additives and in pharmaceutical compositions to be orally administered (with action against lipemia). Said compositions essentially consist of unilamellar liposomes comprising an external lipid phase consisting of class 4 lipids (phospholipids) and an internal aqueous nucleus consisting essentially of a mixture M of at least two different non-polymerisable gelling agents (G1 and G2) whereof the gel-sol phase transition point is not less than 37° C.
Abstract: Microspheres comprising a gelified polar core which is optionally surrounded by concentric and alternating superimposed n lipidic bilayers or n aqueous liquid layers and n gelified polar layers, n being an integer. The microspheres of the invention are obtainable by delipidation of liposomes designated as liposomes having a gelified polar core, of the type comprising at least one outer lipidic bilayer and at least one inner polar aqueous phase containing a gelified substance.
Abstract: Microspheres comprising a gelified polar core which is optionally surrounded by concentric and alternating superimposed n lipidic bilayers or n aqueous liquid layers and n gelified polar layers, n being an integer. The microspheres of the invention are obtainable by delipidation of liposomes designated as liposomes having a gelified polar core, of the type comprising at least one outer lipidic bilayer and at least one inner polar aqueous phase containing a gelified substance.
Type:
Grant
Filed:
December 13, 1996
Date of Patent:
August 31, 1999
Assignee:
Lipogel
Inventors:
Jacques Hauton, deceased, Jean-Pierre Salles