Abstract: Micro-capsules for the slow release of drugs, consisting of a lactic-co-glycolic copolymer to which a plasticiser has been incorporated and which contain a drug of pharmaceutical interested within them.

Abstract: The invention relates to a composition for preventing and treating cellulite, characterized in that it comprises ingredients with lipolytic and venotonic effects, preferably a mixture of caffeine, dry butcher's broom extract (Ruscus Aculeatus), triethanolamine hydroiodide, ivy extract (Hedera helix), L-carnitine and amorphous escine, the tripeptide glycyl-histidyl-lysine, cosmetically acceptable carriers and excipients and water.

Abstract: Use of a glycoprotein produced by Pseudoalteromonas antartica and consisting of 14% carbohydrates and 86% protein in the preparation of pharmaceutical, veterinary and cosmetic compositions for topical or mucous application in the treatment and re-epithelialization of wounds and in the preparation of cosmetic compositions for treatment of skin, hair or nails.

Abstract: The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain said peptide and optionally one or more peptides from the carboxyl end of SNAP-25. Said compositions are suitable for the treatment of facial wrinkles and asymmetry and pathological neuronal exocytosis-mediated pathological disorders and alterations.

Abstract: A procedure for the solid phase peptide synthesis (SPPS), following a linear or convergent strategy, wherein the peptides contain the sequence of general formula (I), wherein n, Y, X and A1 to An have the meanings indicated in the specification. Said procedure comprises: the use of amino acids with the N? group protected, protecting the side chains of those amino acids that have their side chain alkylated or acylated in the final product with labile protecting groups, protecting the side chains of at least one of the amino acids that has its chain free in the final product with hyperlabile products and using a polymeric support which provides labile peptide-resin bonds. Said procedure is valid for the synthesis of gosereline and busereline Y—A1—A2—A3— . . . A(n-1)—An—X.

Abstract: A stable pharmaceutical formulation for intravenous or intramuscular administration of Octreotide, which is characterized in that the vehicle for injection of the peptide or pharmaceutically acceptable salts thereof contains glycine in concentrations ranging from 10 to 60 mM and aqueous solution of hydrochloric acid in sufficient quantity to adjust the pH of the formulation to values between 3.0 and 4.2.

Abstract: A procedure for obtaining the somatostatin analog, octreotide by means of solid phase synthesis on polymer supports and by intervention of protector groups of the Fmoc/tBu type. It includes construction of the seven amino acid, Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)Thr(tBu)-Cys(Trt)-Cl-trityl-R linear peptide, in which R is a polymer; treatment of the resulting peptidyl-resin with acid, for detachment of the peptide from the resin; cycling the linear structure obtained by reaction with iodine before or after incorporation of the threoninol residue into the terminal carboxy end; incorporating the threoninol residue in solution upon the seven amino acid protected peptide with or without the disulfide bridge formed; and removing the protections at the N-terminus and at the side chains with a treatment with 70-95% TFA in presence of scavengers to obtain octreotide.

Abstract: A procedure for obtaining carbocalcitonin comprising the condensation of fragment 1, a docosapeptide corresponding to the carboxamide end of the carbocalcitonin sequence, conveniently protected and anchored on resin, with fragment 2 or 3, a nonapeptide corresponding to the amino end of the salmon calcitonin sequence, with a ready-formed cycle between the Asu and Ser residua, and the treatment of the complete peptide skeleton (fragment 6 or 7) with an acid to free the totally deprotected peptide from the resin.

Abstract: The preparation consists of millispheres, microspheres, nanospheres or array-type particles consisting of a nucleus of a gellable hydrocolloid onto which has been deposited a film of a cationic polysaccharide, and incorporating inside a pharmacologically useful drug. The procedure consists of dissolving, suspending or emulsifying the drug in a solution of the gellable hydrocolloid; adding the resulting mixture to a gelling solution; and suspending the resulting millispheres, microspheres, nanospheres or array-type particles in a solution of the cationic polysaccharide.

Abstract: Liposomes encapsulating doxorubicin, which contain, incorporated into them, a protector compound of general formula A or B, in order to reduce the toxicity of the drug when it is administered in intravenous form, and in which formulas R.sub.1 and R.sub.2, are the same or different, independently represented by HO--, CH.sub.3 O-- or CF.sub.3 CH.sub.

Abstract: A procedure for the preparation of salmon calcitonin comprising the condensation of fragment 1(SEQ ID NO: 1), a docosapeptide corresponding to the carboxamide end of the salmon calcitonin sequence conveniently protected and anchored on resin, with fragment 2(SEQ ID NO:2), a decapeptide corresponding to the amino end of the salmon calcitonin sequence conveniently protected and with a disulphide bridge ready formed between the two cysteines, and the treatment of the complete peptide skeleton (fragment 6 (SEQ ID NO:6)) with an acid to liberate the totally deprotected peptide from the resin.