Patents Assigned to Liquidia Technologies, Inc.
  • Patent number: 11744836
    Abstract: A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: September 5, 2023
    Assignee: Liquidia Technologies, Inc.
    Inventors: Robert Frank Roscigno, Brian T. Farrer, Jacob J. Sprague, Benjamin Maynor
  • Patent number: 11744835
    Abstract: A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: September 5, 2023
    Assignee: Liquidia Technologies, Inc.
    Inventors: Robert Frank Roscigno, Brian T. Farrer, Jacob J. Sprague, Benjamin Maynor
  • Publication number: 20190298854
    Abstract: The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to pH such that above a threshold pH level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.
    Type: Application
    Filed: March 6, 2017
    Publication date: October 3, 2019
    Applicants: GLAXOSMITHKLINE BIOLOGICALS, SA, Liquidia Technologies, Inc.
    Inventors: Abdelatif A ELOUAHABI, Patrick POHLHAUS, Laurent Bernard Jean STRODIOT, Ashley GALLOWAY, Jin Christiane Lee, Michele R. STONE
  • Publication number: 20170320261
    Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.
    Type: Application
    Filed: July 19, 2017
    Publication date: November 9, 2017
    Applicant: Liquidia Technologies, Inc.
    Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
  • Publication number: 20170259461
    Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 14, 2017
    Applicant: Liquidia Technologies, Inc.
    Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
  • Patent number: 9744715
    Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: August 29, 2017
    Assignee: Liquidia Technologies, Inc.
    Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
  • Patent number: 9662809
    Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: May 30, 2017
    Assignee: Liquidia Technologies, Inc.
    Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
  • Publication number: 20170144336
    Abstract: A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity.
    Type: Application
    Filed: January 10, 2017
    Publication date: May 25, 2017
    Applicant: Liquidia Technologies, Inc.
    Inventors: Robert Henn, Alex Ermoshkin, Kyle Henn, Benjamin Maynor, Jason Rolland, Robert Praino
  • Publication number: 20160236379
    Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
    Type: Application
    Filed: April 26, 2016
    Publication date: August 18, 2016
    Applicant: Liquidia Technologies, Inc.
    Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
  • Patent number: 9340001
    Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: May 17, 2016
    Assignee: Liquidia Technologies, Inc.
    Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
  • Patent number: 9314548
    Abstract: A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: April 19, 2016
    Assignee: Liquidia Technologies, Inc.
    Inventors: Lloyd Mahlon Robeson, Ginger Denison Rothrock
  • Publication number: 20160059473
    Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.
    Type: Application
    Filed: November 10, 2015
    Publication date: March 3, 2016
    Applicant: Liquidia Technologies, Inc.
    Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
  • Patent number: 9205594
    Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: December 8, 2015
    Assignee: Liquidia Technologies, Inc.
    Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
  • Publication number: 20150273079
    Abstract: A method of stimulating an immune response in a subject including administering a micrometer-sized particle coupled with an antigen to the subject, wherein increasing the aspect ratio of the micrometer-sized particle increases the immune response. A method of stimulating an immune response in a subject including administering to the subject a plurality of particles, wherein each particle is coupled with an immuno stimulating agent and a protein. A vaccine particle composition including a plurality of particles configured to release a first protein at a first rate and a second protein at a second rate and configured to provide priming and boosting capability in a single dose.
    Type: Application
    Filed: June 11, 2015
    Publication date: October 1, 2015
    Applicant: Liquidia Technologies, Inc.
    Inventors: Bolyn Hubby, Andrew Murphy, Jeff Kindig, Jesse White, Samantha Roth, Ashley L. Galloway, Laura Copp
  • Patent number: 8945441
    Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: February 3, 2015
    Assignee: Liquidia Technologies, Inc.
    Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
  • Patent number: 8945527
    Abstract: The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile —Si-A-C— groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C?O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: February 3, 2015
    Assignees: The University of North Carolina at Chapel Hill, Liquidia Technologies, Inc.
    Inventors: Joseph DeSimone, Matthew Parrott, Andrew Murphy, Robby A. Petros
  • Patent number: 8944804
    Abstract: A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: February 3, 2015
    Assignee: Liquidia Technologies, Inc.
    Inventors: Lloyd M. Robeson, Ginger Denison Rothrock
  • Publication number: 20140131915
    Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
    Type: Application
    Filed: January 17, 2014
    Publication date: May 15, 2014
    Applicant: Liquidia Technologies, Inc.
    Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
  • Patent number: 8662878
    Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 4, 2014
    Assignee: Liquidia Technologies, Inc.
    Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
  • Publication number: 20140027948
    Abstract: A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 30, 2014
    Applicant: Liquidia Technologies, Inc.
    Inventors: Robert HENN, Alex ERMOSHKIN, Kyle HENN, Benjamin MAYNOR, Jason ROLLAND, Robert PRAINO