Patents Assigned to Liquidia Technologies, Inc.
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Patent number: 11744836Abstract: A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.Type: GrantFiled: July 30, 2021Date of Patent: September 5, 2023Assignee: Liquidia Technologies, Inc.Inventors: Robert Frank Roscigno, Brian T. Farrer, Jacob J. Sprague, Benjamin Maynor
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Patent number: 11744835Abstract: A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.Type: GrantFiled: July 30, 2021Date of Patent: September 5, 2023Assignee: Liquidia Technologies, Inc.Inventors: Robert Frank Roscigno, Brian T. Farrer, Jacob J. Sprague, Benjamin Maynor
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Publication number: 20190298854Abstract: The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to pH such that above a threshold pH level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.Type: ApplicationFiled: March 6, 2017Publication date: October 3, 2019Applicants: GLAXOSMITHKLINE BIOLOGICALS, SA, Liquidia Technologies, Inc.Inventors: Abdelatif A ELOUAHABI, Patrick POHLHAUS, Laurent Bernard Jean STRODIOT, Ashley GALLOWAY, Jin Christiane Lee, Michele R. STONE
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Publication number: 20170320261Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.Type: ApplicationFiled: July 19, 2017Publication date: November 9, 2017Applicant: Liquidia Technologies, Inc.Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
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Publication number: 20170259461Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.Type: ApplicationFiled: May 25, 2017Publication date: September 14, 2017Applicant: Liquidia Technologies, Inc.Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
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Patent number: 9744715Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.Type: GrantFiled: November 10, 2015Date of Patent: August 29, 2017Assignee: Liquidia Technologies, Inc.Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
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Patent number: 9662809Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.Type: GrantFiled: April 26, 2016Date of Patent: May 30, 2017Assignee: Liquidia Technologies, Inc.Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
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Publication number: 20170144336Abstract: A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity.Type: ApplicationFiled: January 10, 2017Publication date: May 25, 2017Applicant: Liquidia Technologies, Inc.Inventors: Robert Henn, Alex Ermoshkin, Kyle Henn, Benjamin Maynor, Jason Rolland, Robert Praino
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Publication number: 20160236379Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.Type: ApplicationFiled: April 26, 2016Publication date: August 18, 2016Applicant: Liquidia Technologies, Inc.Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
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Patent number: 9340001Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.Type: GrantFiled: December 18, 2014Date of Patent: May 17, 2016Assignee: Liquidia Technologies, Inc.Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
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Patent number: 9314548Abstract: A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.Type: GrantFiled: December 17, 2014Date of Patent: April 19, 2016Assignee: Liquidia Technologies, Inc.Inventors: Lloyd Mahlon Robeson, Ginger Denison Rothrock
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Publication number: 20160059473Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.Type: ApplicationFiled: November 10, 2015Publication date: March 3, 2016Applicant: Liquidia Technologies, Inc.Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
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Patent number: 9205594Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.Type: GrantFiled: April 22, 2013Date of Patent: December 8, 2015Assignee: Liquidia Technologies, Inc.Inventors: Alexander Ermochkine, Derek Schorzman, Jacob Sprague
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Publication number: 20150273079Abstract: A method of stimulating an immune response in a subject including administering a micrometer-sized particle coupled with an antigen to the subject, wherein increasing the aspect ratio of the micrometer-sized particle increases the immune response. A method of stimulating an immune response in a subject including administering to the subject a plurality of particles, wherein each particle is coupled with an immuno stimulating agent and a protein. A vaccine particle composition including a plurality of particles configured to release a first protein at a first rate and a second protein at a second rate and configured to provide priming and boosting capability in a single dose.Type: ApplicationFiled: June 11, 2015Publication date: October 1, 2015Applicant: Liquidia Technologies, Inc.Inventors: Bolyn Hubby, Andrew Murphy, Jeff Kindig, Jesse White, Samantha Roth, Ashley L. Galloway, Laura Copp
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Patent number: 8945441Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.Type: GrantFiled: January 17, 2014Date of Patent: February 3, 2015Assignee: Liquidia Technologies, Inc.Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
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Patent number: 8945527Abstract: The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile —Si-A-C— groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C?O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material.Type: GrantFiled: April 24, 2009Date of Patent: February 3, 2015Assignees: The University of North Carolina at Chapel Hill, Liquidia Technologies, Inc.Inventors: Joseph DeSimone, Matthew Parrott, Andrew Murphy, Robby A. Petros
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Patent number: 8944804Abstract: A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.Type: GrantFiled: January 4, 2007Date of Patent: February 3, 2015Assignee: Liquidia Technologies, Inc.Inventors: Lloyd M. Robeson, Ginger Denison Rothrock
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Publication number: 20140131915Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.Type: ApplicationFiled: January 17, 2014Publication date: May 15, 2014Applicant: Liquidia Technologies, Inc.Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
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Patent number: 8662878Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.Type: GrantFiled: March 15, 2013Date of Patent: March 4, 2014Assignee: Liquidia Technologies, Inc.Inventors: Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
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Publication number: 20140027948Abstract: A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity.Type: ApplicationFiled: July 25, 2013Publication date: January 30, 2014Applicant: Liquidia Technologies, Inc.Inventors: Robert HENN, Alex ERMOSHKIN, Kyle HENN, Benjamin MAYNOR, Jason ROLLAND, Robert PRAINO