Patents Assigned to Lisapharma Spa
  • Patent number: 5321013
    Abstract: Pharmaceutical compositions in the form of stable sucralfate suspensions free of suspending agents, wherein the sucralfate is present in the form of a gel having self-suspending properties and is suspended in an aqueous carbohydrate solution in a quantity of between 1 and 40% of sucralfate by weight.Said gel has a surface area exceeding 200 m.sup.2 /g and is prepared by dissolving powdered sucralfate in an HCl solution and then precipitating it with an NaOH solution added to a pH of between 4 and 4.5.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: June 14, 1994
    Assignee: Lisapharma SpA
    Inventors: Giorgio G. Z. Zagnoli, Ubaldo Conte, Paolo Colombo, Carla Caramella
  • Patent number: 4605741
    Abstract: The present invention relates to a novel pharmacologically active salt derivative, constituted by 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy-phenyl)-1-butanone 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphate, to the process for the production thereof, and to the related pharmaceutical compositions.Said salt derivative is produced by reacting 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphoric acid with 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-3-butanone in an organic solvent and subsequently crystallizing the reaction product.Said salt derivative carries out an important pharmacological activity as inhibitor of platelet aggregation with vasodilative action.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: August 12, 1986
    Assignee: Lisapharma Spa
    Inventors: Giorgio Zagnoli, Ubaldo Conte, Paolo Colombo