Abstract: The present invention relates to a nanoparticle comprising a polymer, ?-Galactosylceramide (?-GalCer) and chitosan. The invention also relates to multivalent immunogenic compositions. The invention has particular use as a pulmonary vaccine.

Abstract: The present invention relates to compositions comprising a miR-184 modulator, a miR-184, or mimetic, or derivative thereof, an expression vector encoding miR-184, or a carrier molecule conjugated to miR-184 for regulating keratinocyte migration and/or differentiation. The invention has particular use as a medicament for the prevention, management, amelioration or treatment of damaged or defective keratinocytes in a skin condition or disease.

Abstract: A manhole (100) for subterranean installation is described. The manhole (100) comprises a first chamber (110) arranged to receive storm water and a second chamber (120) arranged to receive sewage water. The first chamber (110) comprises a first inlet (111) and a first outlet (112). The second chamber (120) comprises a second inlet (121) and a second outlet (122). The first chamber (110) comprises a first access port (113) opposed to a first base (114) and a first wall (115) arranged therebetween. The second chamber (120) comprises a second access port (123) opposed to a second base (124) and a second wall (125) arranged therebetween. A first normal N1 to the first base (114) extends through the first base (114) and the second base (124). A sewer network 1000 and a method of installing the sewer network are also described.

Abstract: Apparatus and methods are disclosed using electromagnetic (EM) spectroscopy to obtain non-destructively measurements to determine the water activity (Aw) of meat using reflected and/or transmitted signals.

Abstract: Disclosed is a method of manufacturing a Random Telegraph Noise source for use within true random number generators, comprising: subjecting a single semiconductor device to stress for a given period of time; and conditioning the single semiconductor device for a given period of time. Also disclosed is a true random number generator and a method of generating true random numbers.

Abstract: A method and apparatus for analyzing a fluid sample that includes loading the sample in a sample space in a sensor with an input and an output, applying an electromagnetic input signal to the input, measuring at the output a response signal that includes an output signal produced by the sensor while the sensor is contacted by the sample and the electromagnetic input signal is applied to the input, comparing the response signal against the electromagnetic input signal to generate a comparison, and matching the comparison against a set of comparisons for known substances.

Abstract: A method and apparatus for analyzing a fluid sample that includes loading the sample in a sample space in a sensor with an input and an output, applying an electromagnetic input signal to the input, measuring at the output a response signal that includes an output signal produced by the sensor while the sensor is contacted by the sample and the electromagnetic input signal is applied to the input, comparing the response signal against the electromagnetic input signal to generate a comparison, and matching the comparison against a set of comparisons for known substances.

Abstract: A method and apparatus for analyzing a fluid sample comprising loading the sample in a sample space in a sensor with an input and an output for an electromagnetic signal, and measuring an output signal and comparing it against an input signal, and matching the comparison against a set of comparisons for known substances.

Abstract: A computer implemented method for analysing communication between a plurality of individuals. The method comprises reading data representing communications involving a first individual from a data store. A network of the communications between the first individual and a plurality of other individuals is displayed. In the displayed network, each individual is represented by a node and communication between individuals is represented by a link between nodes.

Abstract: Disclosed is a probe for use in a fluid pipeline, comprising: a transmitter for transmitting an RF signal via an antenna (50); a receiver for receiving an RF signal via an antenna; a processor operable to compare the received signal with an expected signal. Also disclosed is a method of assessing the condition of a pipeline by means of a probe located inside the pipeline, comprising the steps of: transmitting an RF signal from the probe; receiving an RF signal at the probe; comparing the received and an expected signal and, based on the result of the comparison, indicating that the pipeline is acceptable or not.

Abstract: There is provided a standing aid comprising a leg engaging means and a handle and wherein the standing aid is adapted such that, in use, a user can brace the leg engaging means against a leg and pull on the handle so that the user is aided to move from a seated position to a standing position. Also provided is a method of using the aid.

Abstract: There is provided a standing aid comprising a leg engaging means and a handle and wherein the standing aid is adapted such that, in use, a user can brace the leg engaging means against a leg and pull on the handle so that the user is aided to move from a seated position to a standing position. Also provided is a method of using the aid.