Abstract: The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.

Abstract: Operating a subject vehicle equipped with an adaptive cruise control system includes setting initial states for control parameters, including setting a desired vehicle speed and determining a desired following gap range, wherein the desired following gap range is associated with a lead vehicle. Operation is controlled via the adaptive cruise control system based upon the initial states for the control parameters. Operation also includes monitoring for presence of the lead vehicle. Upon detecting presence of the lead vehicle, an actual following gap is determined between the subject vehicle and the lead vehicle, and the initial states of the control parameters associated with the adaptive cruise control system are adjusted based upon the actual following gap between the subject vehicle and the lead vehicle, and the desired following gap range. Operation is controlled via the adaptive cruise control system based upon the adjusted initial states of the control parameters.

Abstract: A device for deterring avian pests includes first and second spikes, each having a terminal retention feature held within an injection molded base. The spikes are preferably arranged in a radial fashion, extending outward from the molded base.

Abstract: Methods of immunizing older adult subjects against Streptococcus pneumoniae infection are provided. Provided methods comprise immunization of naïve adult subjects with a conjugated pneumococcal polysaccharide vaccine. Optionally, initial immunization may be followed by additional immunization doses comprising conjugated pneumococcal polysaccharide vaccine or unconjugated pneumococcal polysaccharide vaccine composition.

Abstract: A system for providing dynamic constitutional guidance. The system includes a label generator module configured to receive a periodic longevity factor, retrieve a user periodic longevity factor training set, and generate a naïve Bayes classification algorithm utilizing the user periodic longevity factor training set. The system includes a clustering module configured to receive a user adherence factor, retrieve a user adherence factor training set, and generate a k-means clustering algorithm using the user adherence factor training set. The system includes a processing module the processing module configured to retrieve a user ameliorative plan, evaluate a user ameliorative plan, generate an updated user ameliorative plan, and display the updated user ameliorative plan on a graphical user interface.

Abstract: A system, apparatus, and related methods for the collection, processing, evaluation, transformation, and reporting of individual health care information from diverse information systems and sources. A individual health record (IHR) of the present invention provides a structure for individuals to participate in, and manage, their health and their medical care, while still meeting the needs of health care organizations and caregivers. An IHR object may be formed by obtaining information from diverse health care information systems and sources, and transforming and re-purposing into a coherent account of the individual's overall health and care using a comprehensive health care ontology. As information from various sources is updated or available, the IHR is dynamically updated on a continuous or periodic basis.

Abstract: Systems and methods for allocating electrical energy within a storage cell. Energy stored in an energy storage cell is allocated to multiple energy sub-partitions. Each energy sub-partition is associated with a user. A request to buy an amount of energy from an energy sub-partition assigned to another user is sent by a present user to at least one respective user in the plurality of users. Based on sending the request to sell an amount of energy, at least one response with an offer to sell energy to the present user is received. Acceptance of a selected offer within the at least one response is received, where the selected offer was sent by a winning user. The amount of energy is re-allocated from an energy sub-portion allocated to the winning user to an energy sub-portion associated with the present user based on receiving the acceptance.

Abstract: A computer in a vehicle includes first and second electronic control units (ECUs). The first and second ECUs are programmed to monitor, respectively, a first operating condition and a second operating condition. Each operating condition includes one of path deviation, lane width, user awareness, or steering torque. The second ECU is programmed to monitor the second operating condition according to a protocol with a security measure. The first or second ECU is further programmed to control vehicle operation based on the first or second operating condition.

Abstract: A sliding tray that can slide multiple fiber optic modules simultaneously is provided. In one example, a fiber optic panel assembly includes a ceiling, a bottom cover, and two opposing sides defining an interior opening therein, a mounting bracket disposed on the bottom cover in the interior opening, the mounting bracket comprising a plurality of protruding posts extending outward from a supporting structure of the mounting bracket, and a sliding tray having a plurality of protruding structures having a tip end configured to engage with an inner surface of the supporting structure.

Abstract: Provided is a mechanism for selectively preventing cycling of a semiautomatic handgun having a frame and a longitudinally reciprocating slide. The device includes a pivotal blocking lever on one of the slice or frame. The blocking lever is selectively movable between a first position that allows the slide to cycle when the handgun is fired and a second position in which a blocking member mechanically bridges between the frame and slide to block cycling movement of the slide when the handgun is fired.

Abstract: This disclosure provides recombinant DNA constructs and transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.

Abstract: Methods and systems are provided for variable valve actuation assembly. In one example, the variable valve actuation assembly may include a first pressure reservoir with a first pressure fluidly coupled to valve actuators and positioned below an engine valve. A second pressure reservoir with a second pressure is arranged directly below the first pressure reservoir and a hydraulic medium flows between the first and second pressure reservoirs.

Abstract: A vehicle having a reinforcement brace includes, among other things, an aft structure, a passenger side strut, a driver side strut, a passenger side load transfer frame coupling the aft structure to the passenger side strut and being configured to transfer a load applied to the aft structure from a rear of a vehicle to the passenger side strut, and a driver side load transfer frame coupling the aft structure to the driver side strut and being configured to transfer a load applied to the aft structure from the rear of the vehicle to the driver side strut.

Abstract: The inventive technology includes a novel container dome profile and manufacturing process for improving container and bottle deformation failure resistance and extending material displacement modes through an initial deformation panel coordinated with complimentary geometric paneling and buttressing structures configured to initiate a controlled sequential dome profile deformation mode. Dome reversal, dome growth, and dome drop resistance characteristics are improved with a shallower profile formation depth, reducing pulldown, and lowering material consumption, resulting in lower overall container/bottle weight. Novel geometric contoured shapes enhance container resistance performance, supporting use of softer alloys or lower temper and yield strength to benefit post-processing efficiency and forming processes improvements while being configured to initiate controlled sequential dome profile deformation.

Abstract: An axle assembly having a housing assembly, an electric motor module, and a transmission module. A first lubricant passage may route lubricant from the housing assembly to the transmission housing cavity of the transmission module. The first lubricant passage may extend through a motor housing, a motor cover, and a first transmission housing.

Abstract: An AC electronic solid-state switch includes an electrically insulating and thermally conductive layer, a first electrically conductive trace, a second electrically conductive trace, and a plurality of semiconductor dies each electrically connected to the first electrically conductive trace and the second electrically conductive trace. Each of the plurality of semiconductor dies forms a MOSFET, IGBT or other types of electronically controllable switch. The AC electronic solid-state switch further includes a common drain conductor that is electrically connected to each drain terminal of the plurality of semiconductor dies. The AC electronic solid-state switch is configured to block between 650 volts and 1700 volts in the off-state in a first direction and a second direction, the second direction being opposite the first direction, and the AC electronic solid-state switch is configured to carry at least 500 A continuously in the on-state with a voltage drop of less than 2V.

Abstract: This disclosure relates to vehicle exterior lighting systems that include lamp assemblies that may be customized for meeting customer styling preferences. Exemplary lamp assemblies may include a lamp housing, a removable insert mounted to an interior wall of the lamp housing, and an access panel mounted to the rear exterior surface. The access panel is removable from the rear exterior surface to expose an access opening for inserting or removing the removable insert. The removable insert may include one or more customized features for personalizing the lamp assemblies.

Abstract: A method is disclosed for use in an electronic device having a non-volatile storage device and a volatile storage device, the method comprising: retrieving a first encoded data packet from a first address in the non-volatile storage device; decoding the first encoded data packet to obtain a first data item and a first error code corresponding to the first data item, the first encoded data packet being decoded by using a first coding key that is associated with the first address; detecting whether the first data item is corrupt based on the first error code and an error correction function, storing the first data item at a first address in the volatile storage device when the first data item is not corrupt, and transitioning the electronic device into a safe state when the first data item is corrupt.

Abstract: The present systems and methods are for processing data for monitoring, managing, and displaying a plurality of work flow processes. Specifically, the present system is configured to convert an original workflow document including a plurality of tasks to an interactive procedure platform having the capability of incorporating enriching content correlating to the task elements for receiving input from a user.

Abstract: A system for transferring a frame within an Ethernet network of a vehicle. The system includes an Ethernet switch, first and second feature modules and a NAM. The Ethernet switch includes first and second ports connected respectively to the first and second feature modules. The NAM: receives a priority request message from the second feature module; generates a priority response message indicating information for the second feature module to set a priority level of a frame; and transmits the priority response message to the second feature module. The Ethernet switch: receives the frame from the second feature module at the first port, where the frame has a first bit indicative of the priority level and a second bit indicative of a port of the first feature module; and forwards the frame, based on the first and second bits, to a corresponding one of the queues having the priority level and for transmission to the port of the first feature module.