Abstract: The invention relates to a composition, and a medicament for preventing or stopping of metastases, in particular metastases originating from epithelia cancer, such as skin cancer, lung cancer, stomach cancer, brain cancer, breast cancer, colo-rectal cancer, prostate cancer, pancreas cancer, head/neck cancer, and esophagus cancer. It has been found that the present composition irreversibly converts cancer cells with metastatic potential into harmless cells with no metastatic potential.

Abstract: The invention relates to a pharmaceutical composition, comprising (i) a compound comprising at least one carbohydrate and containing at least one sulphate, in combination with (ii) at least one non-protein or non-NA-strand compound, different from (i), that can activate PPAR, preferably PPAR?, and (iii) optionally, at least one pharmaceutically acceptable carrier. Preferably, the sulphated compounds include single sulphur containing agents like MSM or multiple sulphur containing agents like pentosan, Adequan®. The second part of the composition, is a PPAR? agonists chosen from the group of thiazolidinediones, NSAIDs, sulphonylureas and indoles, like for example indomethacin or pioglitazone.