Abstract: A method for analyzing three-dimensional image data of a target region of a subject, the method comprising identifying a region of interest within the target region containing imaging information predictive of a disease state of the target region, calculating at least two radiomic features associated with the region of interest, and classifying the region of interest based on the calculated radiomic features.

Abstract: The present invention relates to topical glycosaminoglycan compositions, particularly hyaluronan compositions, that facilitate the penetration of modified glycosaminoglycans through the skin barrier into the epidermal and dermal layers of the skin, thereby allowing for the dermal administration of a glycosaminoglycan, such as hyaluronan, without requiring an injection. Through their ability to deliver hyaluronan to the epidermal and dermal layers, the present formulations are therefore suitable for use in dermal rejuvenation, enhancement, hyaluronan replenishment and protection therapy. The glycosaminoglycan compositions are also useful as delivery devices to facilitate the dermal and transdermal delivery of cosmetically and pharmaceutically active substances, including pharmaceuticals, polypeptides, proteins and similarly sized biomacromolecules, through the skin barrier.

Abstract: The present invention concerns compositions comprising and methods of identification and use of imaging agents. The imaging agents comprise a growth hormone secretagogues having a conjugated fluoride. The imaging agents of the present invention may be used for detection, diagnosis and/or staging of prostate or other forms of cancer, and may also be used for cardiac disease.

Abstract: The present invention provides for peptides that bind to Receptor for Hyaluronic Acid Mediated Motility (RHAMM) molecules. More specifically, provided are peptides capable of specifically binding RHAMM molecules and capable of binding RHAMM with substantially high affinity. These novel RHAMM-binding peptides provide the basis for new imaging probes that can be used to identify cells expressing RHAMM, and for methods of imaging, prognosis, diagnosis and treatment of conditions associated with RHAMM expression.

Abstract: The present invention describes a hands-free system for controlling the movement of a cursor on one or more display devices. A tracking device including a traceable marker and one or more accelerometers and gyroscopes are used to track position and acceleration of the marker relative to a target of interest. A processing means processes the motion signals from the tracking device to determine the location of the cursor on the operator's monitor, which may also be displayed on more monitors. The tracking device is worn by the operator, optimally on the operator's head. The operator's head movements determine movement of the cursor.

Abstract: Polypeptides that target and/or bind to EGFL7 or its receptor and thereby reduce EGFL7 pro-angiogenic activity are provided. In this way, the polypeptides are, in an aspect, useful in the treatment of diseases, disorders, or conditions that involve pathological angiogenesis, such as, for example, cancer.

Abstract: A method of treating sepsis comprises administering an agent that inhibits the activity of an miRNA that is upregulated in sepsis.

Abstract: Systems, methods and computer program products to annotate axial-view spine images with the desired characteristics of not requiring additional views of the spine or cross-referencing features are provided. In one aspect, the disclosed method does not require external training from a manually-labeled data set while being applicable to different imaging modalities and acquisition protocols. In one aspect, the disclosed method achieves near real-time results using integral kernels when implemented on a Graphics Processing Unit.

Abstract: Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are citrullinated antigenic peptides having an increased affinity for HLA-DR molecules and associated with Rheumatoid arthritis. These novel peptides provide the basis for new methods of diagnosis and treatment of Rheumatoid arthritis.

Abstract: Systems, methods and computer program products to perform multi-modality vertebrae recognition are provided. Aspects of the present disclosure disclosed and described herein enable a multi-modality vertebrae recognition engine that recognizes vertebrae by using a three-stage recognition approach: landmark detection, global shape registration, and local pose adjustment. These stages cover the matching from local to global spine structures. The three stages are implemented by three modules in the hierarchical deformable model, the local appearance module, global geometry model, and local geometry model. According to one aspect of the present disclosure, the overall workflow can be understood as a three-stage top-down registration. The goal of the registration is: 1) to align the global shape of the spine model, and 2) to align the vertebrae poses with the local image structures around identified landmarks.

Abstract: Methods for identifying subjects having bone loss by detecting bone microparticles in a sample of their bodily fluid are disclosed. Methods for monitoring bone loss and assessing efficacy of bone loss therapies by detecting bone microparticles in bodily fluid samples are also disclosed. Compounds for use as a negative control in the disclosed methods are provided as well as kits comprising such compounds.

Abstract: A method for predicting health compromise in a fetus comprises acquiring one or more EEG signals and a fetal heart rate (FHR) signal from the surface of the head of a fetus; and determining the spectral edge frequency (SEF) of the one or more EEG signals. A repetitive temporal correlation between the FHR signal and the SEF of the one or more EEG signals is indicative of fetal health compromise. A system for detecting the correlation between FHR signal and the SEF of the one or more EEG signals and predicting fetal health compromise is also described.

Abstract: There is provided a composition comprising an effective amount of Annexin A5 for use in treatment of an inflammatory disorder. There is provided a composition comprising an effective amount of Annexin A5 for use in improving organ function. Methods for administering such compositions for treatment of animals are also provided.

Abstract: The present invention provides for peptides that bind to Receptor for Hyaluronic Acid Mediated Motility (RHAMM) molecules. More specifically, provided are peptides capable of specifically binding RHAMM molecules and capable of binding RHAMM with substantially high affinity. These novel RHAMM-binding peptides provide the basis for new imaging probes that can be used to identify cells expressing RHAMM, and for methods of imaging, prognosis, diagnosis and treatment of conditions associated with RHAMM expression.

Abstract: The present invention relates to food-grade bacteria and methods for removing toxic compounds, including lead, cadmium, mercury, arsenic and pesticides, from contaminated environments or substances.

Abstract: Polypeptides that target and/or bind to EGFL7 or its receptor and thereby reduce EGFL7 pro-angiogenic activity are provided. In this way, the polypeptides are, in an aspect, useful in the treatment of diseases, disorders, or conditions that involve pathological angiogenesis, such as, for example, cancer.

Abstract: Methods and apparatus are disclosed to automatically detect vertebrae boundaries in a spine image. A method to detect a vertebra in a spine image is described, the method comprising generating a rectangle approximation of a reference vertebra. The method also including identifying a mask similar to the rectangle approximation and labeling a mask region in the mask. The method also including comparing the mask region to the rectangle approximation and detecting a vertebra in the spine image based on the comparison.

Abstract: The present invention relates to a method of treating or preventing compartment syndrome in a patient. According to the invention, the method includes: (a) identifying a patient suffering from compartment syndrome; and (b) administering to the patient a therapeutically effective amount of a carbon monoxide (CO).

Abstract: Example methods, apparatus and articles of manufacture to process cardiac images to detect heart motion abnormalities are disclosed. A disclosed example method includes using a filter coefficient based on a plurality of cardiac images to characterize motion of a heart; computing an information-theoretic metric from the filter coefficient; and comparing the information-theoretic metric to a threshold to determine whether the motion of the heart is abnormal.

Abstract: Example methods, apparatus and articles of manufacture to track endocardial motion are disclosed. A disclosed example method includes segmenting a plurality of cardiac images of a left ventricle to form respective ones of a plurality of segmented images, updating a plurality of models based on the plurality of segmented images to form respective ones of a plurality of motion estimates for the left ventricle, computing a plurality of probabilities for respective ones of the plurality of models, and computing a weighted sum of the plurality of motion estimates based on the plurality of probabilities, the weighted sum representing a predicted motion of the left ventricle.