Patents Assigned to LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
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Patent number: 11890336Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.Type: GrantFiled: November 16, 2020Date of Patent: February 6, 2024Assignee: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Madeleine Moule
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Patent number: 11365401Abstract: The disclosure relates to an oligosaccharyltransferase polypeptides and their use in the synthesis of glycoconjugates in bacterial cells; vaccines and immunogenic compositions comprising said glycoconjugates and their use in the prevention and/or treatment of bacterial infection. Bacterial expression system comprising said oligosaccharyltransferase polypeptides are also disclosed.Type: GrantFiled: March 14, 2018Date of Patent: June 21, 2022Assignee: London School of Hygiene and Tropical MedicineInventors: Jon Cuccui, Brendan Wren
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Patent number: 11278610Abstract: The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated.Type: GrantFiled: March 17, 2020Date of Patent: March 22, 2022Assignee: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Sherif Abouelhadid
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Patent number: 11179454Abstract: The disclosure relates to attenuated bacterial cells expressing glycans and glycoconjugate antigens and their use in the manufacture of whole cell vaccines effective at preventing or treating bacterial infections in non-human species.Type: GrantFiled: March 14, 2018Date of Patent: November 23, 2021Assignee: London School of Hygiene and Tropical MedicineInventors: Jon Cuccui, Brendan Wren, Alexandra Faulds-Pain
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Publication number: 20210298297Abstract: A mosquito attractant composition is described comprising heptanal, octanal, nonanal, (E)-2-octenal and (E)-2-decenal. More particularly a composition wherein the compounds are present in the following proportions: nonanal 1.00, octanal 0.32±0.16, heptanal 0.06±0.03, (E)-2-octenal 0.04±0.02 and (E)-2-decenal 0.13±0.065.Type: ApplicationFiled: March 25, 2019Publication date: September 30, 2021Applicants: Wageningen Universiteit, London School of Hygiene and Tropical MedicineInventors: Jetske Gudrun de Boer, Ailie Robinson, James George Logan, Joseph Johannes Antonius van Loon, Willem Takken
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Publication number: 20210069312Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.Type: ApplicationFiled: November 16, 2020Publication date: March 11, 2021Applicant: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Madeleine Moule
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Patent number: 10730914Abstract: A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine receptors. Uses of the chemokine in treatment of a range of diseases, including cancers and HIV/AIDS, are described.Type: GrantFiled: December 1, 2017Date of Patent: August 4, 2020Assignees: LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE, DEPARTMENT OF INFECTIOUS & TROPICAL DISEASESInventors: Ursula Gompels, David Dewin, Julie Catusse
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Publication number: 20200215178Abstract: The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated.Type: ApplicationFiled: March 17, 2020Publication date: July 9, 2020Applicant: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Sherif Abouelhadid
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Patent number: 10688176Abstract: The invention relates to an isolated African horse sickness virus (AHSV) ssRNA comprising a plurality of mutations; a complementary cell for replication of a vaccinal viral strain from said ssRNA; a vaccinal viral strain derived from said ssRNA; use of said vaccinal viral strain and/or isolated ssRNA in the vaccination of an animal against an infection by AHSV; a method of vaccination comprising same; and a pharmaceutical composition comprising said vaccinal viral strain and/or said isolated ssRNA.Type: GrantFiled: April 10, 2017Date of Patent: June 23, 2020Assignee: London School of Hygiene & Tropical MedicineInventor: Polly Roy
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Patent number: 10653138Abstract: The present invention provides compounds for attracting bed bugs, compositions thereof, devices comprising said compositions and their use in the detection, monitoring and control of bed bugs.Type: GrantFiled: October 4, 2016Date of Patent: May 19, 2020Assignees: London School of Hygiene & Tropical Medicine, Rothamsted Research LimitedInventors: Mary McFadden Cameron, James George Logan, Emma Natalie Ivy Weeks, John Anthony Pickett, Michael Alexander Birkett
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Patent number: 10646562Abstract: The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated.Type: GrantFiled: February 9, 2018Date of Patent: May 12, 2020Assignee: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Sherif Abouelhadid
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Publication number: 20200054732Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.Type: ApplicationFiled: September 11, 2017Publication date: February 20, 2020Applicant: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Madeleine Moule
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Publication number: 20200032226Abstract: The disclosure relates to an oligosaccharyltransferase polypeptides and their use in the synthesis of glycoconjugates in bacterial cells; vaccines and immunogenic compositions comprising said glycoconjugates and their use in the prevention and/or treatment of bacterial infection. Bacterial expression system comprising said oligosaccharyltransferase polypeptides are also disclosed.Type: ApplicationFiled: March 14, 2018Publication date: January 30, 2020Applicant: London School of Hygiene and Tropical MedicineInventors: Jon Cuccui, Brendan Wren
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Publication number: 20200009241Abstract: The disclosure relates to attenuated bacterial cells expressing glycans and glycoconjugate antigens and their use in the manufacture of whole cell vaccines effective at preventing or treating bacterial infections in non-human species.Type: ApplicationFiled: March 14, 2018Publication date: January 9, 2020Applicant: London School of Hygiene and Tropical MedicineInventors: Jon Cuccui, Brendan Wren, Alexandra Faulds-Pain
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Publication number: 20190059369Abstract: The present invention provides compounds for attracting bed bugs, compositions thereof, devices comprising said compositions and their use in the detection, monitoring and control of bed bugs.Type: ApplicationFiled: October 4, 2016Publication date: February 28, 2019Applicants: London School of Hygiene & Tropical Medicine, Rothamsted Research LimitedInventors: Mary McFadden Cameron, James George Logan, Emma Natalie Ivy Weeks, John Anthony Pickett, Michael Alexander Birkett
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Publication number: 20190060442Abstract: The invention relates to an isolated African horse sickness virus (AHSV) ssRNA comprising a plurality of mutations; a complementary cell for replication of a vaccinal viral strain from said ssRNA; a vaccinal viral strain derived from said ssRNA; use of said vaccinal viral strain and/or isolated ssRNA in the vaccination of an animal against an infection by AHSV; a method of vaccination comprising same; and a pharmaceutical composition comprising said vaccinal viral strain and/or said isolated ssRNA.Type: ApplicationFiled: April 10, 2017Publication date: February 28, 2019Applicant: London School of Hygiene & Tropical MedicineInventor: Polly ROY
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Patent number: 10039812Abstract: The invention relates to deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a pharmaceutical or veterinary composition or formulation comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a combination therapeutic comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection; a method of treating a mammal suspected of being infected with, or infected with, C. difficile comprising the use of at least deoxyribonuclease; a method of cleaning or sterilizing a material or product comprising the use of at least deoxyribonuclease; and a cleaning or sterilizing product impregnated with or containing at least deoxyribonuclease.Type: GrantFiled: November 4, 2015Date of Patent: August 7, 2018Assignee: London School of Hygiene and Tropical MedicineInventors: Lisa Dawson, Brendan Wren
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Patent number: 10039814Abstract: The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.Type: GrantFiled: March 21, 2017Date of Patent: August 7, 2018Assignee: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Madeleine Moule
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Publication number: 20180169212Abstract: The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated.Type: ApplicationFiled: February 9, 2018Publication date: June 21, 2018Applicant: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Sherif Abouelhadid
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Patent number: 9931392Abstract: The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated.Type: GrantFiled: January 17, 2014Date of Patent: April 3, 2018Assignee: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Sherif Abouelhadid