Abstract: The present invention relates to inhalable dry powder formulations comprising one or more antibodies or one or more angiogenesis inhibiting active pharmaceutical ingredients, methods of manufacture of such compositions, e.g. via spray drying, as well as their local administration to the lung for use in the treatment, prevention and/or delay of progression of asthma, COPD, lung infections, cystic fibrosis, or lung cancer.
Type:
Application
Filed:
November 17, 2021
Publication date:
January 4, 2024
Applicant:
Lonza Bend Inc.
Inventors:
Kimberly Shepard, Michael Banks, David Vodak
Abstract: The invention discloses a method for preparation of spray dried solid dispersions, SDD, comprising an active agent, AA, such as an active pharmaceutical ingredient, API, and a dispersion polymer, DISPPOL, wherein the spray drying is done with a solution of AA and of DISPPOL in a solvent comprising C1-3 alkanol and acetic acid, and optionally water.
Type:
Application
Filed:
September 30, 2021
Publication date:
December 28, 2023
Applicant:
Lonza Bend Inc.
Inventors:
Michael Morgen, Warren Miller, David Vodak, Jonathan Cape, Molly Adam
Abstract: The invention discloses a method for preparation of spray dried solid dispersions (SDD) comprising an active pharmaceutical ingredient (API) and a dispersion polymer (DISPPOL), wherein the spray drying is done with a supersaturated solution of API in a solvent mixture comprising two solvents, one is acetic acid, this supersaturated solution further comprising DISPPOL.
Type:
Application
Filed:
July 22, 2021
Publication date:
September 21, 2023
Applicant:
Lonza Bend Inc.
Inventors:
Molly Adam, John Baumann, Nathan Bennette, Warren Miller, Michael Morgen, Amanda Pluntze, Daniel Regan, David Vodak
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