Abstract: Systems and methods for robot-executed site disinfection are provided, employing an autonomous robot equipped with a germicidal light source. In an area that is already mapped with a pre-defined trajectory, the robot may generate a map of delivered dosage and regions of UVC shadows when the robot moves in the environment. Alternatively, the robot may generate a trajectory to be followed, optimized to reduce shadows and minimize electrical energy usage. In an area already mapped, the robot may generate a map of delivered dosage and of shadows. Alternatively, the robot may generate a trajectory to disinfect surfaces based on an area map while reducing shadows and minimizing electrical energy usage. In an unmapped area, the robot may employ an exploration strategy to generate a trajectory to create a map of the area, while simultaneously performing disinfection of surfaces using a minimum amount of electrical energy.