Abstract: A Garcinia mangostana composition, a medication and a health food including the same for enhancing learning ability and memory of a patient with Alzheimer's disease are provided. The Garcinia mangostana composition includes G. mangostana and P. quinquefolius. The net weight ratio of the G. mangostana to the P. quinquefolius ranges from 4:1 to 1:16. A total of 4.5 to 35 mg of G. mangostana is per kilogram bodyweight applied, and 9 to 70 mg of P. quinquefolius per kilogram bodyweight is applied. The G. mangostana composition is capable of reducing the neuronal cell death and increasing the neurite length of the subjects with Alzheimer's disease, as well as improving the short term memory and the long term memory of the test subjects.