Patents Assigned to LSU Medical Center Foundation
  • Process for preparing N-acylated 4-hydroxypenylamine derivatives with analgesic properties
    Patent number: 5621110
    Abstract: The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group of formula I: ##STR1## in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.
    Type: Grant
    Filed: September 18, 1995
    Date of Patent: April 15, 1997
    Assignee: LSU Medical Center Foundation
    Inventors: Nicolas G. Bazan, Julio Alvarez-Builla Gomez
  • N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them
    Patent number: 5554636
    Abstract: The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group, of formula I: ##STR1## in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: September 10, 1996
    Assignee: LSU Medical Center Foundation
    Inventors: Nicolas G. Bazan, Julio Alvarez-Builla Gomez