Abstract: The present invention relates to a novel pharmaceutical formulation comprising an LTB4 agent at an alkaline pH effective to stabilize the LTB4 agent and provide a formulation with an increased shelf-life. The formulation of the present invention has an increased shelf-life of at least 24 months.
Abstract: Leukotriene B4, 5S,12R-dihydroxy-6,8,10,14(Z,E,E,Z)-eicosatetraenoic acid, is a twenty carbon tetra-unsaturated fatty acid. No crystal forms of leukotriene B4 (LTB4) are known in the art. The present inventors have discovered a crystal form of LTB4 and the present invention therefore relates to crystal forms of LTB4 in general, and the novel crystal form A of LTB4 in particular.
Abstract: The present invention relates to a vaccine adjuvant for enhancing immune response of an individual to a vaccine, which comprises an immune-enhancing effective amount of an LTB4 agent in association with a pharmaceutically effective vaccine carrier.
Type:
Grant
Filed:
June 26, 2002
Date of Patent:
March 29, 2011
Assignee:
LTB4 Sweden AB
Inventors:
Louis Flamand, Jean Gosselin, Pierre Borgeat