Abstract: The present invention relates to a transdermal therapeutic system for cutaneous administration of fampridine. The system includes an active ingredient-impermeable backing layer, a pressure-sensitive adhesive reservoir layer and optionally a detachable protective layer. The pressure-sensitive adhesive reservoir layer is formed from fampridine and at least one matrix polymer containing no free carboxylic acid and/or carboxylate groups, with the content of fampridine in the matrix polymer being <5% by weight. On account of the low loading and also the lack of carboxylic acid and/or carboxylate groups in the reservoir layer, it is ensured that the systems administer the active ingredient substantially at higher administration rates than is known in the prior art, and compared to known systems a comparable thermodynamic activity of the active ingredient is achieved. The present invention further relates to a process for producing corresponding transdermal therapeutic systems.

Abstract: The invention relates to an applicator system comprising a microneedle array and to the use thereof for the intradermal delivery of active ingredients, and in particular of medicinal drugs, wherein this microneedle array is suitable for penetrating the skin of humans or animals and includes at least one active ingredient for wound healing.

Abstract: The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one polymer and at least additive.

Abstract: The invention relates to a microneedle array having a heat-generating element and its use for the intradermal application of active ingredients, particularly active pharmaceutical ingredients (API) and drugs, wherein this microneedle array is suitable for skin penetration on humans or animals and the microneedles consist of a water-soluble formulation, which contains at least one active ingredient.

Abstract: The present disclosure relates to a method for producing microneedle arrays in a mold, including a plurality of receptacles that taper from an upper base surface to a lower tip surface, where a first component is fed into at least two receptacles through a feed opening that is spaced apart from the base surface, where the receptacles are filled with an additional component from above the feed opening, where the fillings of at least said two receptacles, which fillings are formed of at least the first component and the additional component, are connected to one another above the base surfaces, and where after the first component and the additional component have solidified, the microneedle array comprising the fillings that have solidified to form needles is removed from the mold.

Abstract: The present invention relates to a microneedle system (MNS for short) for the intradermal application of a hepatitis vaccine, namely the antigen HBsAg.

Abstract: The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one silicone polymer.

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure containing a therapeutically effective amount of asenapine, such asenapine TTS for use in a method of treatment, processes of manufacture of such TTS as well as asenapine and transdermal therapeutic systems containing asenapine for use in a method of treatment and to a method of treating a human patient by transdermal administration of asenapine.

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of solifenacin.

Abstract: Disclosed is a method for producing a porous orodispersible film, having the following steps: i) forming a suspension of a pharmaceutically acceptable solvent, a pharmaceutically acceptable matrix material, and a pharmaceutically acceptable binder, said solvent being selected such that the pharmaceutically acceptable matrix material substantially does not dissolve in it, whereas the pharmaceutically acceptable binder is dissolved in the solvent, ii) casting the suspension onto a neutral support, thereby forming a wet film, and iii) drying the wet film and obtaining a dry film. The films produced in this manner have a closed surface on the lower face whereas the upper face is porous, thereby allowing the application of a pharmaceutically active ingredient in the form of a suspension or a solution for example.

Abstract: The present invention relates to a method for recycling and/or disposal of halocarbons, particularly fluorinated alkanes, such as trifluoromethane, by reacting said halocarbons with sulfur trioxide, particularly to form halide sulfonic acids and sulfur dioxide.

Abstract: Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, in which the inner phase comprises the additive and an active agent dissolved therein, the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, with the maintenance of the permeation rate proportional to the amount of active agent in the biphasic layer.

Abstract: A device for dispensing active ingredient-containing or active ingredient-carrying strips, including a housing in which a coil chamber for receiving an active ingredient-containing or active ingredient-carrying band is arranged, in which a gear transmission with a driven roller for conveying the band is mounted, and in which a separating device for separating the strips from the band is arranged. A method for dispensing active ingredient-containing or active ingredient carrying strips using such a device is also disclosed. An active ingredient-containing or active ingredient-carrying band is arranged between the driven roller and the pressure roller. A shift clutch transmission having a manually actuatable trigger element is arranged upstream of the gear transmission. The driven roller can be driven in incremental strips by the shift clutch transmission. A device and method is disclosed for dispensing active ingredient-containing or active ingredient-carrying strips with a largely equal dosage are developed.

Abstract: The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one silicone acrylic hybrid polymer.

Abstract: The present invention relates to an acceptor chamber for a Franz diffusion cell, comprising an upper opening closable by a membrane and, on the side wall of the acceptor chamber, an upper and a lower outlet opening designed to remove or add liquid medium from the acceptor chamber, the upper outlet opening being located within the upper two thirds of the side wall and the lower outlet opening is located in the lower quarter of the side wall, the upper and lower outlet openings being substantially opposite each other, to a Franz diffusion cell comprising a donor compartment and such an acceptor chamber, the donor compartment and the acceptor chamber being separated from each other by a membrane, and to a method for determining the diffusion of a substance through a membrane with such a Franz diffusion cell.

Abstract: A device for producing microstructures, particularly microneedles and more particularly microneedle arrays, including a female mold that has, on a top side, at least one in particular conical depressed portion for producing a microstructure. The female mold is, for example, in the form of a silicone cap and is connected to a hollow cylinder, in particular via a holding element. A plunger is disposed movably inside the hollow cylinder.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

Abstract: The invention relates to a method and device for testing the adhesion of an adhesive, planar body on a planar substrate, wherein the planar body is applied adhesively on the substrate, the substrate is moistened, and a mechanical force is exerted on the substrate by means of an element in the form of a dumbbell-shaped magnetic stirring rod acting on the side of the substrate facing away from the adhesively applied body, wherein the substrate is repeatedly reversibly deformed at least in parts of the adhesive region of the planar body by means of the exertion of force, and, after a period of time, exertion of the mechanical force is ended, and the remaining adhesion of the planar body is assessed in qualitative and/or quantitative terms.

Abstract: The present invention relates to a microneedle system (MNS) for intradermal application in a controlled release of glucagon-like peptide analogues.

Abstract: The invention relates to transparent therapeutic systems (TTS) which contain the active substance nicotine and which further contain at least one acid amide group as a lateral functional group. The TTS can be transparent and for discreet use. The invention also relates to methods for producing these TTS, said TTS being produced by methods using said polymers and being charged with active substance by way of a printing method.