Patents Assigned to LTS Lohmann Therapie-Systeme AG
  • Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine
    Patent number: 9925150
    Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: March 27, 2018
    Assignees: LTS Lohmann Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Hans-Michael Wolff, Christoph Arth, Luc Quere, Walter Müller
  • SINGLE-USE INJECTOR HAVING A RELEASE ASSEMBLY UNIT FOR SIMPLIFIED ASSEMBLY
    Publication number: 20180056001
    Abstract: A single-use injector having a plunger actuator which is mounted in a housing, which is loaded by a spring energy store, and which can be unlocked by a movable release device. The plunger actuator can be supported by a traction rod mounted in the housing. The movable release device includes a casing housing. The casing housing includes an upper shell and a lower shell, the separation line of which is oriented in the longitudinal direction of the single-use injector. The casing housing has a cornerless cross-section deviating from a circular shape. The housing is anti-rotationally centered in the casing housing.
    Type: Application
    Filed: October 25, 2017
    Publication date: March 1, 2018
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: SARA FORGHANI, KARSTEN HEUSER, SEBASTIAN SCHERR, UWE WORTMANN
  • DISPOSABLE INJECTOR WITH INCREASED TRIGGERING RELIABILITY
    Publication number: 20180056000
    Abstract: A disposable injector with a piston actuation ram is mounted in a housing, is loaded by a spring energy accumulator and can be unlocked by a displaceable trigger device. The piston actuation ram can be supported by a tensioning rod mounted in the housing. The trigger device comprises a trigger ring displaceable relative to the housing. The tensioning rod can be supported directly or indirectly by a bearing surface of the trigger ring. The bearing surface encloses an angle of between ten degrees and forty five degrees with the longitudinal direction of the disposable injector. The point of the angle lies offset with respect to the trigger ring in the triggering direction of the disposable injector. A disposable injector with increased trigger reliability is developed.
    Type: Application
    Filed: October 25, 2017
    Publication date: March 1, 2018
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: SARA FORGHANI, UWE WORTMANN, KARSTEN HEUSER, HEIKO SPILGIES
  • Transdermal therapeutic system with pressure generating device
    Patent number: 9895521
    Abstract: A transdermal therapeutic system with a system support, at least one advancing element which is embedded into the system support, and at least one active ingredient reservoir which can be elastically deformed at least in some regions and which is embedded into the advancing element. On the application side of the transdermal therapeutic system, the system support surrounds the advancing element, and the advancing element surrounds the active ingredient reservoir. The advancing element comprises a swelling body which can be expanded by means of a liquid intake. The system support is designed to be rigid at least in some regions. A transdermal therapeutic system is developed which enhances the effect of the advancing element.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: February 20, 2018
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Patrick Mohr
  • Transdermal therapeutic system for the administration of peptides
    Patent number: 9895319
    Abstract: The invention relates to a transdermal therapeutic system (TTS), which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system includes a back layer and an active substance-containing layer that contains at least one peptide and a carrier substance, preferably as a textile web material.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: February 20, 2018
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Gerd Hoffmann, Sandra Wiedersberg
  • DISPOSABLE INJECTOR HAVING A SOUND-PROOFING LAYER
    Publication number: 20180021516
    Abstract: A disposable injector comprising a housing, a spring-loaded piston-actuating plunger arranged in the housing and able to be released by a trigger unit. A cylinder-piston unit comprising a cylinder and a piston that is positioned at a distance from the piston-actuating plunger. A closed layer made on an elastically-deformable material surrounds the piston-actuating plunger in at least some sections and projects beyond same in the trigger direction, resulting in a disposable injector that will not alarm a patient during use thereof.
    Type: Application
    Filed: October 2, 2017
    Publication date: January 25, 2018
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: THORSTEN SICHTERMANN, UWE WORTMANN
  • Wafer and capsule formulations with enhanced dissolution rates for fenofibrate
    Patent number: 9849184
    Abstract: The invention relates to developing a novel water and capsule formulation using fenofibrate which is difficult to dissolve and control its release rate in vitro. For example, the invention relates to the creation of capsules and wafers comprising: fenofibrate, a surfactant, a carrier wax, a film former, a plasticizer, and optionally a super disintegrant or other ingredients. The invention further relates to the process of forming such capsules and wafers.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: December 26, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Li, Markus Krumme
  • Wafer Comprising Steroid Hormones
    Publication number: 20170348321
    Abstract: The invention relates to a pharmaceutical composition in the form of a system in film form for transmucosal administration of steroid hormones. An administration system for steroid hormones which dissolves in the mouth and which releases with a high bioavailability is disclosed. The administration system in film form dissolves in the mouth preferably in a period of less than 30 min, and the steroid hormone entering the bloodstream transmucosally from the administration system leads to a rapid rise in the concentration in the blood. It is thus possible to achieve a maximum concentration of this steroid hormone in the blood in a period of less than 60 min after administration.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 7, 2017
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Markus Krumme, Albert Radlmaier, Sescha General, Michael Dittgen, Keith Jensen
  • Transdermal therapeutic system having controlled active substance flow comprising a basic reacting oxide
    Patent number: 9833418
    Abstract: The present invention relates to transdermal therapeutic systems that include an occlusive back layer impervious to an active substance, a single or multilayer matrix, and a peelable protective film. The matrix or at least one of the matrix layers includes a pharmaceutical active substance or a plurality of pharmaceutical active substances in the form of at least one pharmaceutically consumable salt thereof and a pharmaceutically consumable, alkaline reacting oxide.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: December 5, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: René Eifler, Regine Kaufmann, Patrick Mohr
  • DEXAMETHASONE ORAL FILM
    Publication number: 20170304319
    Abstract: The present invention relates to an oral film consisting essentially of dexamethasone and hydroxypropyl methylcellulose, wherein the concentration of dexamethasone is 30% w/w or more and the concentration of hydroxypropyl methylcellulose is between 35 and 70% w/w based on total dry matter.
    Type: Application
    Filed: November 4, 2015
    Publication date: October 26, 2017
    Applicants: ACUCORT AB, LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Bengt Arvid WESTRIN
  • Oral film containing opiate enteric-release beads
    Patent number: 9763879
    Abstract: A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: September 19, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Michael Li
  • Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy
    Patent number: 9717698
    Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer-based layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the polymer-based layer remote from the skin and the skin-contact layer.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 1, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Walter Mueller
  • Cylinder-piston unit with adhesive disc I
    Patent number: 9717853
    Abstract: A cylinder-piston unit of a needle-free injector, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the center line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. The adhesive disc has an adhesive coating on each of the two end faces. In the installation position, the discharge tube can be sealed off in the adhesive disc. In the application position, the front edge of the discharge nozzle lies in the plane of the front adhesive coating or protrudes beyond this plane by at least 0.5 mm.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: August 1, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Rudolf Matusch
  • USE OF SEMI-FLUORINATED ALKANES IN TRANSDERMAL THERAPEUTIC SYSTEMS
    Publication number: 20170182060
    Abstract: The invention relates to the use of semi-fluorinated alkanes, in particular mixed with ethanol, as solubilising agents, permeation promoters and/or enhancers for lipophilic and/or poorly skin-permeable pharmaceutical agents that are administered via a transdermal therapeutic system (TTS), and to corresponding TTSs containing such substances.
    Type: Application
    Filed: May 7, 2015
    Publication date: June 29, 2017
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Sandra WIEDERSBERG, Bernhard GÜNTHER, Dieter SCHERER
  • Oral film containing opiate enteric-release beads
    Patent number: 9687445
    Abstract: A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: June 27, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Michael Hsin Chwen Li
  • Childproof highly-inert packaging for individually dosed films containing an active ingredient
    Patent number: 9637293
    Abstract: A childproof packaging for individual doses, in particular for preparations for administration in film form, wherein the packaging constitutes a bag produced by sealing, which has a covering layer which is provided at each side of the packaging with local weak points which do not touch the edge of the packaging, wherein the local weak points form a cohesive pattern which runs around the individual dose in an arc or a curve and overlaps an angular region of at least 90° when considered from the main area of the individual zone. The local weak points have a start area and an end area which have a Y configuration when the local weak points on each side of the packaging are superposed.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: May 2, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Markus Krumme, Grace A. Behrend, Stephen J. Dodd
  • Transdermal Delivery System Containing Rotigotine
    Publication number: 20170105945
    Abstract: Transdermal therapeutic system for the transdermal administration of rotigotine containing an therapeutically effective amount of rotigotine base in a self-adhesive layer structure, comprising A) a backing layer, and B) a rotigotine-containing biphasic layer, the bi phasic layer having a) an outer phase having a composition comprising 75% to 100% of a polymer or a polymer mixture, and b) an inner phase having a composition comprising rotigotine base, wherein the inner phase forms dispersed deposits in the outer phase, and wherein the inner phase comprises i. rotigotine base, and ii.
    Type: Application
    Filed: May 20, 2015
    Publication date: April 20, 2017
    Applicants: LTS Lohmann Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Marc Emgenbroich, Elke Klein, Heike Kluth
  • Transdermal therapeutic system having improved long-term wearing comfort
    Patent number: 9616045
    Abstract: The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: April 11, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Thomas Hille, Lothar Deurer
  • Method for Adjusting the Release of Active Agent in a Transdermal Delivery system
    Publication number: 20170079932
    Abstract: Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, wherein the inner phase comprises the additive and an active agent dissolved therein, wherein the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, wherein the maintenance of the permeation rate is proportional to the amount of active agent in the biphasic layer.
    Type: Application
    Filed: May 20, 2015
    Publication date: March 23, 2017
    Applicants: LTS Lohmann Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Marco Emgenbroich, Johannes Josef Leonhard, Hans-Michael Wolff
  • Childproof, highly inert individual packaging
    Patent number: 9597852
    Abstract: A method for producing childproof, highly inert individual dose packagings for transdermal therapeutic systems or film-like forms of administration in the form of a sealing edge bag that can be peeled back with a complete surrounding and continuous sealing surface, comprising two packaging elements, that are arranged on top of each other and form the upper side and the bottom side of a bag containing the product, wherein at least one layer of the packaging material elements is a metal layer and at least one packaging material element a film laminate with at least three-layer design; and the outer layer of the at least three-layer film laminate comprises at least one line-shaped weakening that is not touching the edge of the packaging on the upper and bottom side and the line-shaped weakening has a reduced resistance to tear for opening the packaging.
    Type: Grant
    Filed: July 18, 2015
    Date of Patent: March 21, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Markus Krumme