Abstract: A system and method for producing pain-management formulations that amplify and improve the effects of lower doses of the active ingredients in existing pain-management medications is disclosed. Active ingredients in medications are combined in smaller doses, for example, 25% of typical approved or prescribed doses with a natural ingredient used to amplify the effects of the active ingredient without adversely affecting a human's organs. In one embodiment, the combined formulation comprises an active drug ingredient, for example naproxen, combined with a designated amount of a natural ingredient in a symbiotic relationship in a natural USP grade carrier oil to formulate a blended composition that is effective yet safe. The symbiotic relationship between the synthetic and natural ingredients serve to amplify the effects of the active synthetic ingredient for pain management while preventing the adverse effects caused by increased medication potency on a human body's organs.