Abstract: An enhancement resonator (20) being configured for generating intra-resonator laser light (1) by coherent superposition of input laser light, comprises at least three resonator mirrors (21, 22, 23, 24) spanning a ring resonator path in one common resonator plane, said resonator path being free of a laser light amplifying medium, wherein the at least three resonator mirrors (21, 22, 23, 24) include at least two toroidal mirrors and/or at least one cylindrical mirror. Furthermore, a laser device (100) comprising the enhancement resonator (20) and a method of generating intra-resonator laser light (1) are described.

Abstract: The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1, which may be fully reversibly interconverted between non-tubulin-binding trans and tubulin-binding as isomeric forms, either by irradiation or spontaneously.

Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.

Abstract: Disclosed herein is a coherent dynamically controllable narrow band light source (10), comprising a first sub-light source (12), said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, a Raman active medium (30) suitable to cause Raman scattering of light having said first wavelength, a second sub-light source (20) capable of emitting light with a second wavelength, said second wavelength being longer than said first wavelength, and an optical fiber or wave guide, wherein said light emitted by said first and second sub-light sources traverses a length of said optical fiber (30) or wave guide in a feed-forward configuration to facilitate a non-linear wavelength conversion step involving said Raman-active medium. At least one of said first and second sub-light sources (12, 20) has a coherence length longer than 0.05 mm, preferably longer than 0.5 mm and most preferably longer than 2 mm.

Abstract: The invention relates to 3,3?-dinitro-5,5?-bis-triazole-1,1?-diol and to salts thereof, and to an energetic active mass comprising said salts.

Abstract: A laser pulse amplifier device (100) includes an amplifying cavity (10) comprising an amplifying laser gain medium (11) and multiple cavity mirrors (12.1 to 12.7) spanning a cavity light path (13), wherein the amplifying cavity (10) is configured for an amplification of laser pulses (1) circulating along the cavity light path, and a multi-pass amplifier (20) being optically coupled with the amplifying cavity (10) and comprising multiple deflection mirrors (22) spanning a multipass light path (23), wherein the multi-pass amplifier (20) is configured for a post-amplification of laser pulses (2) coupled out of the amplifying cavity (10), wherein the amplifying cavity (10) and the multi-pass amplifier (20) are arranged such that the laser gain medium (11) of the amplifying cavity (10) is included as an active medium in the multi-pass light path (23) of the multi-pass amplifier (20). Furthermore, a method of amplifying laser pulses is described.

Abstract: The invention relates to the use of non-immunosuppressive cyclophilin inhibitors in the treatment of Coronavirus infection in a patient.

Abstract: The present invention relates to compounds acting as selective inhibitors of CD40-TRAF6 interaction, their use as medicaments and their use in the treatment of (chronic) inflammatory diseases. The present invention also relates to pharmaceutical compositions comprising these compounds.

Abstract: The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.

Abstract: A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first mode shaping section (13). Furthermore, a method of generating laser pulses (1) using a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12) is described.

Abstract: The invention relates to the use of non-immunosuppressive cyclophilin inhibitors in the treatment of Coronavirus infection in a patient.

Abstract: A Fabry-Pérot tuneable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of optical resonance frequencies with a sweep frequency of 70 kHz or more. And the mechanical coupling between selected elements of the arrangement is sufficiently low such that when operated at the sweep frequency, the selected elements act as a system of coupled oscillating elements. In addition or alternatively, the first actuator means is directly or indirectly coupled with the first reflecting element so as to substantially drive the first reflecting element only.

Abstract: Shown are a device (26) and a method for detecting the deflection of a plurality of elastic elements (22), wherein the elastic elements (22) can be deflected out of a rest position against a restoring force and are suitable as resonators and/or for measuring a force acting on a respective elastic element (22). The elastic elements (22) are arranged periodically, The arrangement of the elastic elements (22) is illuminated using light, the coherence length of which is larger than the average spacing of adjacent elastic elements (22). A diffraction image is hereby created of the illuminating light scattered on the arrangement of elastic elements (22), and at least a portion of the diffraction image is detected by an optical sensor (32) directly or after interaction with further optical components. The detected image or image signal is subsequently analyzed in order to determine information relating to the deflection state of the elastic elements (22) therefrom.

Abstract: A method of controlling output pulses of a pulse laser device (100) including thin-disk laser medium (10), in particular controlling a carrier-envelope phase and/or an intensity noise of the output pulses, includes pumping thin-disk laser medium (10) of pulse laser device (100) with multiple pump laser diodes (21, 22, 23), having at least one modulated laser diode (21, 22) powered by current source (31, 32) with modulation capability, and controlling the output pulses by modulating the output power of the at least one modulated laser diode (21, 22), which is modulated by controlling a drive current thereof, wherein the pump laser diodes further include at least one stable laser diode (23), having constant output power, and the output power of the at least one modulated laser diode (21, 22) is smaller than the whole output power of the stable laser diode(s) (23). A pulse laser device (100) is also described.

Abstract: A laser pulse amplifier device (100) includes an amplifying cavity (10) comprising an amplifying laser gain medium (11) and multiple cavity mirrors (12.1 to 12.7) spanning a cavity light path (13), wherein the amplifying cavity (10) is configured for an amplification of laser pulses (1) circulating along the cavity light path, and a multi-pass amplifier (20) being optically coupled with the amplifying cavity (10) and comprising multiple deflection mirrors (22) spanning a multipass light path (23), wherein the multi-pass amplifier (20) is configured for a post-amplification of laser pulses (2) coupled out of the amplifying cavity (10), wherein the amplifying cavity (10) and the multi-pass amplifier (20) are arranged such that the laser gain medium (11) of the amplifying cavity (10) is included as an active medium in the multi-pass light path (23) of the multi-pass amplifier (20). Furthermore, a method of amplifying laser pulses is described.

Abstract: A method of spatially relaying a first radiation component (1) having a first wavelength and a second radiation component (2) having a second wavelength different from the first radiation component (1), using an optical relaying device (10) which comprises a transparent plate (11) having anti-reflection coatings (12, 13) on both side surfaces thereof, comprises transmitting the first radiation component (1) across the optical relaying device (10) with predetermined incident (a) and emergent angles (?), resp., wherein said anti-reflection coatings (12, 13) being effective for the first radiation component (1) at the incident and emergent angles (?, ?), resp., and reflecting the second radiation component (2) at the optical relaying device (10) with a predetermined reflection angle (a) being equal to at least one of said incident and emergent angles (?, ?), wherein the first and second radiation components (1, 2) are split from each other toward different directions or combined into a common beam path.

Abstract: The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) ofindividual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).

Abstract: The present invention relates to S100 family proteins and their uses. Moreover, the present invention relates to pharmaceutical compositions comprising an S100 family protein.

Abstract: In at least one embodiment, a wavelength-tunable light source includes at least one fiber-based partial section and at least one delay section. For a wavelength ? of at least one portion of a radiation emitted by the light source as a function of time t, the relationship ?(t)=?(t??) holds true. In this case, ? is a specific period of time. Furthermore, the delay section includes one or more oligomode fibers.

Abstract: A Fabry-Pérot tunable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of optical resonance frequencies with a sweep frequency of 70 kHz or more. And the mechanical coupling between selected elements of the arrangement is sufficiently low such that when operated at the sweep frequency, the selected elements act as a system of coupled oscillating elements. In addition or alternatively, the first actuator means is directly or indirectly coupled with the first reflecting element so as to substantially drive the first reflecting element only.