Patents Assigned to Ludwig-Maximilians-Universitat
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Publication number: 20160185730Abstract: The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.Type: ApplicationFiled: December 22, 2015Publication date: June 30, 2016Applicants: Ludwig-Maximilians-Universität München, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Armin Giese, Uwe Bertsch, Hans Kretzschmar, Matthias Habeck, Thomas Hirschberger, Paul Tavan, Christian Griesinger, Andrei Leonov, Sergey Ryazanov, Petra Frick née Weber, Markus Geissen, Martin H. Groschup, Jens Wagner
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Publication number: 20160140595Abstract: There is provided a method of processing electronic coupons, comprising: allocating a unique code to each of a plurality of electronic coupons; enabling a mobile device to receive one or more of said codes, and to store said codes in a memory of the mobile device, wherein each code is associated with one or more attributes, including a value of the corresponding electronic coupon; enabling the mobile device to output a code associated with a user-selected electronic coupon to another device.Type: ApplicationFiled: February 8, 2013Publication date: May 19, 2016Applicant: LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHENInventors: MARTIN WERNER, CLAUDIA LINNHOFF, STEPHAN VERCLAS, FLORIAN GSCHWANDTNER, CONSTANTIN SCHEUERMANN
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Patent number: 9334237Abstract: A reagent of the formula R1R2N—ZnY LiY??(I) wherein R1 and R2 are independently, selected from H, aryl or heteroaryl, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together form part of a cyclic or polymeric structure; R1 and/or R2 is not H; Y is F, Cl, Br, I, CN, SCN, NCO or HalOn, wherein n=3 or 4 and Hal is Cl, Br or I; NO3; BF4; PF6; H; a carboxylate of formula R5CO2; an alcoholate of formula OR5; a thiolate of formula SR5; R5P(O)O2; or SCOR5; or SCSR5; OnSR5; wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein R5 is an aryl or heteroaryl, linear, branched or cyclic, alkyl, alkenyl, alkynyl, or derivatives thereof, or H; or as adduct with a solvent; and preparation and use thereof.Type: GrantFiled: February 11, 2010Date of Patent: May 10, 2016Assignee: Ludwig-Maximilians-Universitat MunchenInventors: Paul Knochel, Marc Mosrin
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Patent number: 9246312Abstract: A Fabry-Pérot tuneable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of optical resonance frequencies with a sweep frequency of 70 kHz or more. And the mechanical coupling between selected elements of the arrangement is sufficiently low such that when operated at the sweep frequency, the selected elements act as a system of coupled oscillating elements. In addition or alternatively, the first actuator means is directly or indirectly coupled with the first reflecting element so as to substantially drive the first reflecting element only.Type: GrantFiled: September 4, 2014Date of Patent: January 26, 2016Assignee: Ludwig-Maximilians-Universität MünchenInventors: Robert Huber, Wolfgang Wieser, Thomas Klein, Christoph Eigenwillig, Benjamin Biedermann, Dieter Muellner, Michael Eder
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Publication number: 20150125897Abstract: The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) ofindividual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).Type: ApplicationFiled: October 2, 2014Publication date: May 7, 2015Applicant: Ludwig Maximilians Universität MünchenInventors: Stefan DUHR, Philipp Baaske
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Patent number: 8999669Abstract: The present invention relates to a nucleic acid molecule encoding a polypeptide specifically binding to proliferating cell nuclear antigen (PCNA). The present invention also relates to a vector comprising the nucleic acid molecule of the invention, a host cell comprising the nucleic acid molecule of or the vector of the invention and a method of detecting the amount and/or location of PCNA in living cells, a method of screening for compounds having an effect on the cell cycle.Type: GrantFiled: July 6, 2010Date of Patent: April 7, 2015Assignee: Ludwig-Maximilians Universitat MünchenInventors: Ulrich Rothbauer, Heinrich Leonhardt, Kourosh Zolghadr, Tina Romer, Katrin Schmidthals
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Publication number: 20150055136Abstract: At least one embodiment of the method is designed to create a two-dimensional image of a three-dimensional sample.Type: ApplicationFiled: March 21, 2013Publication date: February 26, 2015Applicant: Ludwig Maximilians Universitat MunchenInventors: Robert Alexander Huber, Thomas Klein, Wolfgang Wieser
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Publication number: 20150050311Abstract: The present invention relates to a method for the preparation of a strain-adapted vaccine specific for a bacterial strain, comprising the steps of: (a) genetically engineering a bacterial strain obtained from a subject, wherein said genetic engineering comprises introducing a nucleic acid molecule encoding a fusion protein, wherein the fusion protein comprises a bacterial membrane protein fused to at least one affinity tag, (b) growing the genetically engineered bacterial strain obtained in step (a) in solution, (c) isolating membrane vesicles from the growth culture of step (b) by affinity purification using the affinity tag, and (d) formulating the membrane vesicles isolated in step (c) into a strain-adapted vaccine. The present invention further relates to a nucleic acid molecule encoding a fusion protein comprising a bacterial membrane protein fused to at least one affinity tag and a kit comprising said fusion protein.Type: ApplicationFiled: April 5, 2013Publication date: February 19, 2015Applicant: Ludwig-Maximilians-Universitat MünchenInventors: Sören Schubert, Andreas Wieser
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Patent number: 8941080Abstract: The present invention pertains to a device and method to measure thermo-optical, preferably thermophoretic, characteristics of particles in a solution. The method comprises the steps of: (a) providing a sample probe comprising marked particles in a solution; (b) providing a temperature control system for creating a temperature gradient within said sample probe by contact heating, electrical heating and/or cooling; (c) detecting the marked particles at a first time; (d) creating a temperature gradient within the sample probe by means of the temperature control system; (e) detecting the marked particles in the sample probe at a, preferably predetermined, second time and/or at a predetermined location within the temperature gradient, and (f) characterizing the particles based on said two detections.Type: GrantFiled: May 20, 2009Date of Patent: January 27, 2015Assignee: Ludwig-Maximilians-Universitat MunchenInventors: Stefan Duhr, Philipp Baaske, Dieter Braun, Christoph Jens Wienken
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Publication number: 20140371292Abstract: The present invention relates to a method for the controlled intracellular delivery of nucleic acid molecules into one or more target cells, in particular tumor cells, the method comprising: providing a polymeric complex formed between one or more nucleic acid molecules to be delivered and one or more cationic carrier molecules, wherein at least a part of the one or more carrier molecules in the polymeric complex are covalently attached to hydroxyalkyl starch, and wherein the hydroxyalkyl starch is shielding the polymeric complex; allowing the shielded polymeric complex to get into contact with the one or more target cells; deshielding the polymeric complex by removing the hydroxyalkyl starch; and allowing the deshielded polymeric complex to internalize into the one or more target cells. Removal of the hydroxyalkyl starch can be accomplished enzymatically by exposing the polymeric complex to amylase.Type: ApplicationFiled: August 10, 2012Publication date: December 18, 2014Applicant: Ludwig-Maximilians-Universitat MunchenInventors: Ahmed Besheer, Matthaus Noga, Gerhard Winter, Ernst Wagner, Daniel Edinger
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Patent number: 8855149Abstract: A Fabry-Pérot tunable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of optical resonance frequencies with a sweep frequency of 70 kHz or more. And the mechanical coupling between selected elements of the arrangement is sufficiently low such that when operated at the sweep frequency, the selected elements act as a system of coupled oscillating elements. In addition or alternatively, the first actuator means is directly or indirectly coupled with the first reflecting element so as to substantially drive the first reflecting element only.Type: GrantFiled: August 13, 2012Date of Patent: October 7, 2014Assignee: Ludwig-Maximilians-Universität MünchenInventors: Robert Huber, Wolfgang Wieser, Thomas Klein, Christoph Eigenwillig, Benjamin Biedermann, Dieter Muellner, Michael Eder
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Patent number: 8853650Abstract: The present invention relates to a method and an apparatus for a fast thermo-optical characterization of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).Type: GrantFiled: April 26, 2013Date of Patent: October 7, 2014Assignee: Ludwig Maximilians Universitat MunchenInventors: Stefan Duhr, Phillip Baaske
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Patent number: 8741570Abstract: The present invention pertains to a method and a device for the determination of thermo-optical properties, particularly the size or size distribution, of fluorescently labeled biomolecules or biomolecule complexes, particularly nucleic acids, in a reaction solution.Type: GrantFiled: February 6, 2009Date of Patent: June 3, 2014Assignee: Ludwig-Maximilians-Universitat MunchenInventors: Stefan Duhr, Philipp Baaske
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Patent number: 8669283Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.Type: GrantFiled: February 4, 2009Date of Patent: March 11, 2014Assignee: Ludwig-Maximilians-Universitat MunchenInventors: Stephan A. Sieber, Thomas Böttcher
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Publication number: 20140031545Abstract: Processes for making an organozinc reagents are disclosed comprising reacting (A) organomagnesium or organozinc complexes with (B) at least one coordination compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex. The resulting organozinc reagents may optionally be isolated from solvents to obtain a solid reagent. The reagents may be used for making organic compounds via Negishi cross-coupling reactions or via aldehyde and/or ketone oxidative addition reactions.Type: ApplicationFiled: December 21, 2011Publication date: January 30, 2014Applicant: LUDWIG-MAXIMILIAN-UNIVERSITAT MUNCHENInventors: Paul Knochel, Sebastian Bernhardt, Georg Manolikakes
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Publication number: 20130323747Abstract: The present invention relates to a method of detecting the presence, amount or subcellular location of an antigenic structure of interest in a cell.Type: ApplicationFiled: May 20, 2013Publication date: December 5, 2013Applicant: Ludwig-Maximilians-Universitat MunchenInventors: Ulrich Rothbauer, Heinrich Leonhardt
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Patent number: 8586317Abstract: The present invention relates to methods of diagnosing hypophosphatemic disorders.Type: GrantFiled: April 11, 2011Date of Patent: November 19, 2013Assignees: Advanced Research & Technology Institute, Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche GenetikInventors: Michael Econs, Kenneth E. White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20130287700Abstract: Subject of the present invention are compounds with high affinity for the A? protein, ?-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in vivo diagnosis of neurodegenerative disorders like e.g. Alzheimer's disease and Parkinson's disease. The compounds are characterized by suitable physicochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) as well as a high affinity and selectivity for the target proteins.Type: ApplicationFiled: September 20, 2011Publication date: October 31, 2013Applicants: KLINIKUM DARMSTADT GMBH, TECHNISCHE UNIVERSITAT DARMSTADT, LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHENInventors: Boris Schmidt, Daniel Kieser, Alexander Boländer, Jochen Herms, Roland Heyny-Von Haussen, Jiamin Gu
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Patent number: 8563598Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.Type: GrantFiled: February 4, 2009Date of Patent: October 22, 2013Assignee: Ludwig-Maximilians-Universitat MunchenInventors: Stephan A. Sieber, Thomas Böttcher
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Publication number: 20130237697Abstract: The present invention relates to building blocks and methods for the efficient synthesis of 5-hydroxymethylcytosine-containing nucleic acids such as DNA or RNA.Type: ApplicationFiled: November 11, 2011Publication date: September 12, 2013Applicant: LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHENInventors: Thomas Carell, Martin Munzel