Abstract: The present invention relates to a bispecific (monoclonal) antibody molecule with a first binding domain binding an antigen on CD8+ T-cells that does not naturally occur in and/or on CD8+ T-cells and a second binding domain binding to a tumor specific antigen naturally occurring on the surface of a tumor cell. The bispecific (monoclonal) antibody molecules are particularly useful in combination with transduced CD8+ T-cells comprising an antigen which does not naturally occur in and/or on CD8+ T-cells and/or a T-cell receptor.
Type:
Grant
Filed:
January 24, 2013
Date of Patent:
April 28, 2020
Assignees:
Hoffmann-La Roche Inc., Ludwig-Maximillians-Universität München
Inventors:
Carole Bourquin, Raffaella Castoldi, Stefan Endres, Christian Klein, Sebastian Kobold, Gerhard Niederfellner, Claudio Sustmann
Abstract: A radiation source that provides high order harmonic radiation (HHG radiation) in an UV or XUV wavelength range comprising a resonant cavity that guides laser light pulses that includes at least two cavity mirrors, a first non-linear medium that provides the HHG radiation by harmonic generation based on an interaction of the laser light pulses with the first non-linear medium, wherein the first non-linear medium is arranged in the resonant cavity in an environment of reduced pressure, and a second non-linear medium arranged in the resonant cavity and adapted for at least one of amplifying the laser light pulses and phase locking longitudinal modes of the laser light pulses in the resonant cavity.
Type:
Grant
Filed:
January 23, 2009
Date of Patent:
November 12, 2013
Assignees:
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Ludwig-Maximillians-Universitat Muenchen
Inventors:
Ferenc Krausz, Jens Rauschenberger, Alexander Apolonskiy