Patents Assigned to LUMEN BIOSCIENCE, INC.
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Patent number: 12503682Abstract: The present disclosure provides non-parenteral compositions comprising a recombinant Spirulina comprising at least one exogenous therapeutic. Compositions of the present disclosure can be used as vaccines and/or therapeutic drugs. The present disclosure also provides methods of making recombinant Spirulina comprising at least one exogenous therapeutic, and methods of treatment.Type: GrantFiled: May 3, 2021Date of Patent: December 23, 2025Assignee: Lumen Bioscience, Inc.Inventors: James Roberts, Michael Tasch, Mesfin Gewe, Benjamin Jester, Tracy Saveria
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Patent number: 12466883Abstract: Provided are compositions comprising leptin and methods of using the same to support weight loss. Also provided are modified leptins, including recombinant leptins, and methods of making and using the same.Type: GrantFiled: May 13, 2025Date of Patent: November 11, 2025Assignee: LUMEN BIOSCIENCE, INC.Inventors: James Michael Roberts, Mesfin Mulugeta Gewe, Uland Lau, Mark Heinnickel, Michael Dodds, David Bolick, Nhi Yen Khuong, Hannah Tabakh, Brian Finrow, Jennifer Lynn Wierman
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Patent number: 12447202Abstract: The present disclosure provides oral antigenic compositions comprising a recombinant Spirulina comprising at least one exogenous antigenic epitope. Oral antigenic compositions of the present disclosure can be used as vaccines. Oral antigenic compositions of the present disclosure can be used to induce a protective immune response to infectious microorganism, tumor antigens, or self-antigens.Type: GrantFiled: May 17, 2019Date of Patent: October 21, 2025Assignee: Lumen Bioscience, Inc.Inventors: James Roberts, Michael A. Tasch, Tracy Saveria
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Patent number: 12252513Abstract: Provided herein are novel thermostable phycobiliproteins. These proteins may be stabilized by the introduction of disulfide bonds which stabilize the protein. Modified cells expressing these thermostable phycobiliproteins and methods of making them are also provided.Type: GrantFiled: July 16, 2019Date of Patent: March 18, 2025Assignee: Lumen Bioscience, Inc.Inventors: James Roberts, Ryo Takeuchi, Nhi Khuong, Barry L Stoddard, Rolf Kuestner
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Patent number: 12065638Abstract: This disclosure describes techniques for creating stable, targeted mutations in Spirulina (Arthrospira) and Spirulina having stable, targeted mutations.Type: GrantFiled: September 13, 2019Date of Patent: August 20, 2024Assignee: Lumen Bioscience, Inc.Inventors: Ryo Takeuchi, James Roberts
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Patent number: 11279912Abstract: This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria, that have a reduced amount of a light harvesting protein (LHP) and contain one or more introduced or overexpressed polynucleotides encoding one or more enzymes associated with lipid biosynthesis, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.Type: GrantFiled: August 21, 2020Date of Patent: March 22, 2022Assignee: LUMEN BIOSCIENCE, INC.Inventors: James Roberts, Michael Carleton, Damian Carrieri, Jason W. Hickman
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Patent number: 11174294Abstract: Microorganisms with increased photosynthetic capacity are described. Increased photosynthetic capacity is achieved by down-regulating activity of the RpaB pathway. The microorganisms include Cyanobacteria, including genetically-modified Cyanobacteria.Type: GrantFiled: May 14, 2020Date of Patent: November 16, 2021Assignee: Lumen Bioscience, Inc.Inventors: James Roberts, Damian Carrieri, Mark Heinnickel
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Patent number: 10787488Abstract: Photosynthetic microorganisms with broadened light absorption capability and increased photosynthetic activity are described. Broadened light absorption is achieved by modifying the microorganism to utilize non-native bilins. Increased photosynthetic activity results from the broadened light absorption and can also result from a decrease in self-shading. The microorganisms include Cyanobacteria, including modified Cyanobacteria.Type: GrantFiled: July 7, 2016Date of Patent: September 29, 2020Assignees: LUMEN BIOSCIENCE, INC., RELIANCE HOLDING USA, INC.Inventors: James Roberts, David M. Doughty
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Patent number: 10760045Abstract: This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria, that have a reduced amount of a light harvesting protein (LHP) and contain one or more introduced or overexpressed polynucleotides encoding one or more enzymes associated with lipid biosynthesis, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.Type: GrantFiled: February 14, 2020Date of Patent: September 1, 2020Assignee: LUMEN BIOSCIENCE, INC.Inventors: James Roberts, Michael Carleton, Damian Carrieri, Jason W. Hickman
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Patent number: 10654901Abstract: Microorganisms with increased photosynthetic capacity are described. Increased photosynthetic capacity is achieved by down-regulating activity of the RpaB pathway. The microorganisms include Cyanobacteria, including genetically-modified Cyanobacteria.Type: GrantFiled: April 22, 2016Date of Patent: May 19, 2020Assignees: Lumen Bioscience, Inc., Reliance Holding USA, Inc.Inventors: James Roberts, Damian Carrieri, Mark Heinnickel
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Patent number: 10563168Abstract: This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria that have a reduced amount of a light harvesting protein (LHP) and contain one or more introduced or overexpressed polynucleotides encoding one or more enzymes associated with lipid biosynthesis, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.Type: GrantFiled: January 25, 2018Date of Patent: February 18, 2020Assignee: LUMEN BIOSCIENCE, INC.Inventors: James Roberts, Michael Carleton, Damian Carrieri, Jason W. Hickman
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Patent number: 10415012Abstract: This disclosure describes techniques for creating stable, targeted mutations in Spirulina (Athrospiria) and Spirulina having stable, targeted mutations.Type: GrantFiled: July 2, 2018Date of Patent: September 17, 2019Assignee: LUMEN BIOSCIENCE, INC.Inventors: Ryo Takeuchi, James Roberts
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Patent number: 10336982Abstract: This disclosure describes techniques for creating stable, targeted mutations in Spirulina (Arthrospira) and Spirulina having stable, targeted mutations.Type: GrantFiled: July 2, 2018Date of Patent: July 2, 2019Assignee: LUMEN BIOSCIENCE, INC.Inventors: Ryo Takeuchi, James Roberts
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Patent number: 10131870Abstract: This disclosure describes techniques for creating stable, targeted mutations in Spirulina (Athrospiria) and Spirulina having stable, targeted mutations.Type: GrantFiled: September 9, 2015Date of Patent: November 20, 2018Assignee: LUMEN BIOSCIENCE, INC.Inventors: Ryo Takeuchi, James Roberts
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Patent number: 9914907Abstract: This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria, that have a reduced amount of a light harvesting protein (LHP) and contain one or more introduced or overexpressed polynucleotides encoding one or more enzymes associated with lipid biosynthesis, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.Type: GrantFiled: March 10, 2014Date of Patent: March 13, 2018Assignee: LUMEN BIOSCIENCE, INC.Inventors: James Roberts, Michael Carleton, Damian Carrieri, Jason W. Hickman
