Patents Assigned to LUNDBECK LA JOLLA RESEARCH CENTER, INC.
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Patent number: 11680046Abstract: Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.Type: GrantFiled: June 3, 2021Date of Patent: June 20, 2023Assignees: Celgene Corporation, Lundbeck La Jolla Research Center, Inc.Inventors: Lianfeng Huang, Nancy Tsou, Nicole Suzanne White, Jun Xu, Qun Zhang
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Publication number: 20210206735Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.Type: ApplicationFiled: May 14, 2019Publication date: July 8, 2021Applicant: Lundbeck La Jolla Research Center, Inc.Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
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Patent number: 11021453Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.Type: GrantFiled: December 17, 2019Date of Patent: June 1, 2021Assignees: LUNDBECK LA JOLLA RESEARCH CENTER, INC., THE SCRIPPS RESEARCH INSTITUTEInventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M. Lum, Benjamin F. Cravatt
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Patent number: 10927105Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.Type: GrantFiled: June 12, 2020Date of Patent: February 23, 2021Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Cheryl A. Grice, John J. M. Wiener, Olivia D. Weber, Katharine K. Duncan
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Patent number: 10899737Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.Type: GrantFiled: September 18, 2017Date of Patent: January 26, 2021Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi, Olivia D. Weber
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Patent number: 10781211Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.Type: GrantFiled: May 11, 2017Date of Patent: September 22, 2020Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Daniel J. Buzard, Michael B. Shaghafi, Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Olivia D. Weber
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Patent number: 10570106Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.Type: GrantFiled: May 14, 2019Date of Patent: February 25, 2020Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
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Patent number: 10519134Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.Type: GrantFiled: November 18, 2016Date of Patent: December 31, 2019Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Olivia D. Weber, Michael B. Shaghafi, Cheryl A. Grice, Todd K. Jones
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Patent number: 10463753Abstract: Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.Type: GrantFiled: February 17, 2017Date of Patent: November 5, 2019Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Cheryl A. Grice, Todd K. Jones, Justin S. Cisar, Iain Peter Fraser
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Patent number: 10450302Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.Type: GrantFiled: May 10, 2016Date of Patent: October 22, 2019Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Jacqueline Lorayne Blankman, Jason Robert Clapper, R. Alan B. Ezekowitz, Iain Peter Fraser, Cheryl A. Grice, Todd K. Jones, Gary Paul O'Neill, Archie Wayne Thurston, Jr., Channing Rodney Beals
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Patent number: 10385057Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.Type: GrantFiled: November 18, 2016Date of Patent: August 20, 2019Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.Inventors: Cheryl A. Grice, Todd K. Jones, Katharine K. Duncan, Olivia D. Weber, Justin S. Cisar, Jeffrey E. Merit